CD4+ T-cell cytokine response in WT and Ras-deficient mice early after L major challenge
| . | WT . | H-ras KO . | N-ras KO . |
|---|---|---|---|
| IFN-γ+ | 17.4 ± 1.9 | 5.5 ± 0.7 (.015*) | 5.8 ± 0.5 (.041*) |
| IL-4+ | 1.2 ± 0.9 | 1.2 ± 0.5 (.709) | 0.8 ± 0.3 (.520) |
| . | WT . | H-ras KO . | N-ras KO . |
|---|---|---|---|
| IFN-γ+ | 17.4 ± 1.9 | 5.5 ± 0.7 (.015*) | 5.8 ± 0.5 (.041*) |
| IL-4+ | 1.2 ± 0.9 | 1.2 ± 0.5 (.709) | 0.8 ± 0.3 (.520) |
Values represent the percentage (mean ± SD; 2 mice per group) of CD4+ T cells positive for the indicated cytokine, as determined by cytometric intracellular staining, in anti–CD3/CD28-stimulated (48 hours) draining lymph node cells 1 week after parasite challenge. P values versus WT using unpaired t test are shown in parentheses.
Significant difference.