Definitions of time to event endpoints
| Endpoint . | Definition . |
|---|---|
| TTP | Duration from start of treatment to disease progression, with deaths from causes other than progression censored. |
| PFS | Duration from start of the treatment to disease progression or death (regardless of cause of death), whichever comes first. |
| EFS | The definition for EFS depends on how “event” is defined. In many studies, the definition of EFS used is the same as PFS. EFS may include additional “events” that are considered to be of importance besides death and progression, including serious drug toxicity. |
| DFS | Duration from the start of CR to the time of relapse from CR. DFS applies only to patients in complete CR. |
| DOR | Duration from first observation of PR to the time of disease progression, with deaths from causes other than progression censored.* Duration of CR and PR should each be reported. |
| Endpoint . | Definition . |
|---|---|
| TTP | Duration from start of treatment to disease progression, with deaths from causes other than progression censored. |
| PFS | Duration from start of the treatment to disease progression or death (regardless of cause of death), whichever comes first. |
| EFS | The definition for EFS depends on how “event” is defined. In many studies, the definition of EFS used is the same as PFS. EFS may include additional “events” that are considered to be of importance besides death and progression, including serious drug toxicity. |
| DFS | Duration from the start of CR to the time of relapse from CR. DFS applies only to patients in complete CR. |
| DOR | Duration from first observation of PR to the time of disease progression, with deaths from causes other than progression censored.* Duration of CR and PR should each be reported. |
Reproduced from Durie et al7 and Anderson al5 with permission.
Duration of response includes only patients with confirmed responses. For the purposes of the calculation of the duration of response, as long as the response has been confirmed, the date at which the response status was first observed rather than the date of confirmation is used as the start date.