Clinical trials of interferon in essential thrombocythemia
| First author, year . | No. of patients . | Response rate, % . | Discontinuation, n (%) . | Type of IFN . |
|---|---|---|---|---|
| Giles, 1988 | 18 | 100% | 0 | α2a and α2b |
| Bellucci, 1988 | 12 | NA | 4 (33) | α2a |
| Gugliotta, 1989 | 10 | 100 | NA | α2a |
| Lazzarino, 1989 | 26 | 86 | 9 (35) | α2b |
| Giralt, 1991 | 13 | 69 | NA | α2b |
| Gisslinger, 1991 | 20 | 85 | 10 (50) | α2c |
| Sacchi, 1991 | 35 | 85 | 4 (11) | α2b |
| Turri, 1991 | 10 | 70 | 1 (10) | α2a |
| Seewann, 1991 | 19 | 80 | 6 (30) | α2b |
| Kasparu, 1992 | 14 | 86 | 0 | α2b |
| Rametta, 1994 | 25 | 92 | NA | α2b |
| Berte, 1996 | 12 | 83 | NA | α2a and α2b |
| Sacchi, 1998 | 11 | 100 | 1 (9) | α |
| Radin, 2003 | 17 | 88 | NA | α2 |
| Alvarado, 2003 | 11 | 100 | 2 (18) | peg-α2b |
| Saba, 2005 | 20 | 75 | 3 (15) | α2a |
| Langer, 2005 | 36 | 75 | 13 (36) | peg-α2b |
| Samuelsson, 2006 | 21 | 70 | 11 (55) | peg-α2b |
| Jabbour, 2007 | 13 | 70 | NA | peg-α2b |
| Quintas-Cardama, 2009 | 39 | 81 | NA | peg-α2a |
| First author, year . | No. of patients . | Response rate, % . | Discontinuation, n (%) . | Type of IFN . |
|---|---|---|---|---|
| Giles, 1988 | 18 | 100% | 0 | α2a and α2b |
| Bellucci, 1988 | 12 | NA | 4 (33) | α2a |
| Gugliotta, 1989 | 10 | 100 | NA | α2a |
| Lazzarino, 1989 | 26 | 86 | 9 (35) | α2b |
| Giralt, 1991 | 13 | 69 | NA | α2b |
| Gisslinger, 1991 | 20 | 85 | 10 (50) | α2c |
| Sacchi, 1991 | 35 | 85 | 4 (11) | α2b |
| Turri, 1991 | 10 | 70 | 1 (10) | α2a |
| Seewann, 1991 | 19 | 80 | 6 (30) | α2b |
| Kasparu, 1992 | 14 | 86 | 0 | α2b |
| Rametta, 1994 | 25 | 92 | NA | α2b |
| Berte, 1996 | 12 | 83 | NA | α2a and α2b |
| Sacchi, 1998 | 11 | 100 | 1 (9) | α |
| Radin, 2003 | 17 | 88 | NA | α2 |
| Alvarado, 2003 | 11 | 100 | 2 (18) | peg-α2b |
| Saba, 2005 | 20 | 75 | 3 (15) | α2a |
| Langer, 2005 | 36 | 75 | 13 (36) | peg-α2b |
| Samuelsson, 2006 | 21 | 70 | 11 (55) | peg-α2b |
| Jabbour, 2007 | 13 | 70 | NA | peg-α2b |
| Quintas-Cardama, 2009 | 39 | 81 | NA | peg-α2a |
For complete references, see supplemental Table 3.
IFN indicates interferon; and NA, data not available.