Table 3 SHM characteristics in the most... | American Society of Hematology

Table 3

SHM characteristics in the most common IGHV families

	No. of sequences	No. of mutations	R/S ratio			Transitions/transversions			% of mutations within RGYW	% of nucleotides within RGYW
	No. of sequences	No. of mutations	Total	CDR	FR	Total	CDR	FR	% of mutations within RGYW	% of nucleotides within RGYW
HCLc
IGHV1c	15	242	1.66	2.95	1.3	1.57	1.76	1.26	16.94	3.96
IGHV3c	55	705	1.92	2.73	1.52	1.50	1.40	1.66	13.62	3.09
IGHV4c	24	213	1.73	4.40	1.31	1.24	1.37	0.93	12.68	3.71
HCLv
IGHV1v	2	45	2	3	1.64	1.14	1.42	0.78	13.33	3.72
IGHV3v	7	111	1.89	2.25	1.73	0.76	0.63	1.05	8.11	3.19
IGHV4v	16	64	1.75	1.38	2	2.05	2.46	1.38	6.25	3.88

	No. of sequences	No. of mutations	R/S ratio			Transitions/transversions			% of mutations within RGYW	% of nucleotides within RGYW
	No. of sequences	No. of mutations	Total	CDR	FR	Total	CDR	FR	% of mutations within RGYW	% of nucleotides within RGYW
HCLc
IGHV1c	15	242	1.66	2.95	1.3	1.57	1.76	1.26	16.94	3.96
IGHV3c	55	705	1.92	2.73	1.52	1.50	1.40	1.66	13.62	3.09
IGHV4c	24	213	1.73	4.40	1.31	1.24	1.37	0.93	12.68	3.71
HCLv
IGHV1v	2	45	2	3	1.64	1.14	1.42	0.78	13.33	3.72
IGHV3v	7	111	1.89	2.25	1.73	0.76	0.63	1.05	8.11	3.19
IGHV4v	16	64	1.75	1.38	2	2.05	2.46	1.38	6.25	3.88