Impacts of influenza virus type on clinical outcomes among HCT recipients, by multivariable analyses
| Outcome . | Virus type . | Influenza B* . | 2009 H1N1* . | ||||
|---|---|---|---|---|---|---|---|
| Influenza A (N = 103) . | Influenza B (N = 40) . | 2009 H1N1 (N = 18) . | Adjusted OR or HR (95% CI)† . | P . | Adjusted OR or HR (95% CI)† . | P . | |
| LRD | 22 (21.4) | 10 (25.0) | 10 (55.6) | 0.70 (0.3-1.9) | .49 | 6.48 (1.4-31) | .02 |
| Hypoxemia | 22 (21.4) | 11 (27.5) | 10 (55.6) | 0.85 (0.3-2.1) | .73 | 3.96 (1.1-15) | .04 |
| Mechanical ventilation | 8 (7.8) | 4 (10.0) | 5 (27.8) | 0.39 (0.1-1.8) | .24 | 2.59 (0.5-15) | .29 |
| Time to death by day 42 | 11 (10.7) | 6 (15.0) | 3 (16.7) | 0.95 (0.3-2.7) | .92 | 0.93 (0.2-4.6) | .93 |
| Time to influenza-associated death | 8 (7.8) | 4 (10.0) | 3 (16.7) | 0.86 (0.2-3.0) | .82 | 1.15 (0.2-5.9) | .87 |
| Outcome . | Virus type . | Influenza B* . | 2009 H1N1* . | ||||
|---|---|---|---|---|---|---|---|
| Influenza A (N = 103) . | Influenza B (N = 40) . | 2009 H1N1 (N = 18) . | Adjusted OR or HR (95% CI)† . | P . | Adjusted OR or HR (95% CI)† . | P . | |
| LRD | 22 (21.4) | 10 (25.0) | 10 (55.6) | 0.70 (0.3-1.9) | .49 | 6.48 (1.4-31) | .02 |
| Hypoxemia | 22 (21.4) | 11 (27.5) | 10 (55.6) | 0.85 (0.3-2.1) | .73 | 3.96 (1.1-15) | .04 |
| Mechanical ventilation | 8 (7.8) | 4 (10.0) | 5 (27.8) | 0.39 (0.1-1.8) | .24 | 2.59 (0.5-15) | .29 |
| Time to death by day 42 | 11 (10.7) | 6 (15.0) | 3 (16.7) | 0.95 (0.3-2.7) | .92 | 0.93 (0.2-4.6) | .93 |
| Time to influenza-associated death | 8 (7.8) | 4 (10.0) | 3 (16.7) | 0.86 (0.2-3.0) | .82 | 1.15 (0.2-5.9) | .87 |
Data are no. (%) of patients, unless otherwise indicated. The year of influenza diagnosed was forced into the multivariable models for all endpoint analyses. Influenza virus type, lymphocyte count, and early antiviral therapy were included as variables in all analyses. Multivariable models also included stem cell source for LRD analysis, acute GVHD for hypoxemia analysis, and corticosteroid treatment for mechanical ventilation analysis.
Seasonal influenza A is the reference.
ORs are shown for risk for LRD, hypoxemia, and mechanical ventilation, and HRs are shown elsewhere.