Summary of factors associated with increased risk of grades 2-4 acute and chronic GVHD
| Factor . | Acute GVHD . | Chronic GVHD . | ||
|---|---|---|---|---|
| Previously reported* . | Current study . | Previously reported† . | Current study‡ . | |
| HLA mismatch or unrelated donor | yes | yes | yes | yes |
| Older patient age | yes | no | yes | yes |
| Older donor age | yes | yes | yes | yes |
| Female donor for male recipient | yes | yes | yes | yes |
| Parity of female donor (allosensitization) | yes | § | yes | § |
| Intensity of conditioning regimen | yes | ‖ | no | ‖ |
| Mobilized blood cell graft | no/yes | no | yes | yes |
| Donor lymphocyte infusion | yes | ¶ | yes | ¶ |
| Prior acute GVHD | n/a | n/a | yes | yes |
| Factor . | Acute GVHD . | Chronic GVHD . | ||
|---|---|---|---|---|
| Previously reported* . | Current study . | Previously reported† . | Current study‡ . | |
| HLA mismatch or unrelated donor | yes | yes | yes | yes |
| Older patient age | yes | no | yes | yes |
| Older donor age | yes | yes | yes | yes |
| Female donor for male recipient | yes | yes | yes | yes |
| Parity of female donor (allosensitization) | yes | § | yes | § |
| Intensity of conditioning regimen | yes | ‖ | no | ‖ |
| Mobilized blood cell graft | no/yes | no | yes | yes |
| Donor lymphocyte infusion | yes | ¶ | yes | ¶ |
| Prior acute GVHD | n/a | n/a | yes | yes |
n/a indicates not applicable.
Results from selected large studies.7-10,12,14,16,21,22
Historically defined chronic GVHD.
By NIH chronic GVHD criteria.
Not consistently reported or data not available for analysis.
DLI was treated as a competing risk in our analysis for risk factors for GVHD.
All patients received a high-intensity conditioning regimen.