Multivariate analysis of risk factors for NIH chronic GVHD before and after adjustment for acute GVHD
| Risk factor . | Adjustment for acute GVHD,* HR (95% CI) . | |
|---|---|---|
| No . | Yes . | |
| Unrelated donor | 1.35 (1.14-1.59) | 1.30 (1.10-1.54) |
| HLA-mismatched related donor | 1.30 (1.01-1.68) | 1.24 (0.95-1.60) |
| HLA-mismatched unrelated donor | 1.76 (1.47-2.11) | 1.67 (1.39-2.00) |
| Female donor for male patient | 1.38 (1.21-1.59) | 1.37 (1.19-1.57) |
| Mobilized blood cell grafts | 1.74 (1.45-2.08) | 1.74 (1.46-2.08) |
| Diagnosis of CML | 0.86 (0.75-1.00) | 0.88 (0.77-1.02) |
| Conditioning with TBI | 1.11 (0.96-1.28) | 1.07 (0.92-1.34) |
| Conditioning with ATG | 0.68 (0.45-1.02) | 0.70 (0.47-1.06) |
| Patient age per decade | 1.13 (1.07-1.19) | 1.13 (1.07-1.19) |
| Donor age per decade | 1.09 (1.03-1.16) | 1.09 (1.02-1.15) |
| Acute GVHD grade† | ||
| 1 | n/a | 0.90 (0.62-1.30) |
| 2 | n/a | 1.14 (0.95-1.37) |
| 3-4 | n/a | 1.42 (1.14-1.77) |
| Risk factor . | Adjustment for acute GVHD,* HR (95% CI) . | |
|---|---|---|
| No . | Yes . | |
| Unrelated donor | 1.35 (1.14-1.59) | 1.30 (1.10-1.54) |
| HLA-mismatched related donor | 1.30 (1.01-1.68) | 1.24 (0.95-1.60) |
| HLA-mismatched unrelated donor | 1.76 (1.47-2.11) | 1.67 (1.39-2.00) |
| Female donor for male patient | 1.38 (1.21-1.59) | 1.37 (1.19-1.57) |
| Mobilized blood cell grafts | 1.74 (1.45-2.08) | 1.74 (1.46-2.08) |
| Diagnosis of CML | 0.86 (0.75-1.00) | 0.88 (0.77-1.02) |
| Conditioning with TBI | 1.11 (0.96-1.28) | 1.07 (0.92-1.34) |
| Conditioning with ATG | 0.68 (0.45-1.02) | 0.70 (0.47-1.06) |
| Patient age per decade | 1.13 (1.07-1.19) | 1.13 (1.07-1.19) |
| Donor age per decade | 1.09 (1.03-1.16) | 1.09 (1.02-1.15) |
| Acute GVHD grade† | ||
| 1 | n/a | 0.90 (0.62-1.30) |
| 2 | n/a | 1.14 (0.95-1.37) |
| 3-4 | n/a | 1.42 (1.14-1.77) |