Table 2

Multivariate analysis of risk factors for NIH chronic GVHD before and after adjustment for acute GVHD

Risk factorAdjustment for acute GVHD,* HR (95% CI)
NoYes
Unrelated donor 1.35 (1.14-1.59) 1.30 (1.10-1.54) 
HLA-mismatched related donor 1.30 (1.01-1.68) 1.24 (0.95-1.60) 
HLA-mismatched unrelated donor 1.76 (1.47-2.11) 1.67 (1.39-2.00) 
Female donor for male patient 1.38 (1.21-1.59) 1.37 (1.19-1.57) 
Mobilized blood cell grafts 1.74 (1.45-2.08) 1.74 (1.46-2.08) 
Diagnosis of CML 0.86 (0.75-1.00) 0.88 (0.77-1.02) 
Conditioning with TBI 1.11 (0.96-1.28) 1.07 (0.92-1.34) 
Conditioning with ATG 0.68 (0.45-1.02) 0.70 (0.47-1.06) 
Patient age per decade 1.13 (1.07-1.19) 1.13 (1.07-1.19) 
Donor age per decade 1.09 (1.03-1.16) 1.09 (1.02-1.15) 
Acute GVHD grade   
    1 n/a 0.90 (0.62-1.30) 
    2 n/a 1.14 (0.95-1.37) 
    3-4 n/a 1.42 (1.14-1.77) 
Risk factorAdjustment for acute GVHD,* HR (95% CI)
NoYes
Unrelated donor 1.35 (1.14-1.59) 1.30 (1.10-1.54) 
HLA-mismatched related donor 1.30 (1.01-1.68) 1.24 (0.95-1.60) 
HLA-mismatched unrelated donor 1.76 (1.47-2.11) 1.67 (1.39-2.00) 
Female donor for male patient 1.38 (1.21-1.59) 1.37 (1.19-1.57) 
Mobilized blood cell grafts 1.74 (1.45-2.08) 1.74 (1.46-2.08) 
Diagnosis of CML 0.86 (0.75-1.00) 0.88 (0.77-1.02) 
Conditioning with TBI 1.11 (0.96-1.28) 1.07 (0.92-1.34) 
Conditioning with ATG 0.68 (0.45-1.02) 0.70 (0.47-1.06) 
Patient age per decade 1.13 (1.07-1.19) 1.13 (1.07-1.19) 
Donor age per decade 1.09 (1.03-1.16) 1.09 (1.02-1.15) 
Acute GVHD grade   
    1 n/a 0.90 (0.62-1.30) 
    2 n/a 1.14 (0.95-1.37) 
    3-4 n/a 1.42 (1.14-1.77) 

HR indicates hazard ratio; and n/a, not applicable.

*

HRs are relative to patients without the risk factor.

Time-dependent covariate.

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