Table 2

CDR-region sequences and amino acid positions in parental anti-CAIX G250 antibody chains and scFv(G250)-chimeric receptor

Antibody regionAmino acid sequence*Amino acid position in
Parental antibody chainsscFv chimeric receptor
Heavy chain    
    H-CDR1 NYYMS 31-35 50-54 
    H-CDR2 AINSDGGITYYLDTVKG 50-66 69-85 
    H-CDR3 HRSGYFSMDY 99-108 118-127 
Light chain    
    L-CDR1 KASQNVVSAVA 24-34 180-190 
    L-CDR2 SASNRYT 50-56 206-212 
    L-CDR3 QQYSNYPWT 89-97 245-253 
Antibody regionAmino acid sequence*Amino acid position in
Parental antibody chainsscFv chimeric receptor
Heavy chain    
    H-CDR1 NYYMS 31-35 50-54 
    H-CDR2 AINSDGGITYYLDTVKG 50-66 69-85 
    H-CDR3 HRSGYFSMDY 99-108 118-127 
Light chain    
    L-CDR1 KASQNVVSAVA 24-34 180-190 
    L-CDR2 SASNRYT 50-56 206-212 
    L-CDR3 QQYSNYPWT 89-97 245-253 
*

CDR amino acid sequences G250 mAb heavy and light chains from European patent application EP1733736A2; published 20-12-2006 Bulletin 2006/51.

View Large