Follow-up of the maternal anti–HPA-1a antibody concentrations during managed pregnancies
| Weighted AUC, IU/mL per wks of gestation . | Newborn platelet count, × 109/L (95% CI) . | P . | Sensitivity, % . | Specificity, % . | PPV, % . | NPV, % . | |
|---|---|---|---|---|---|---|---|
| < 50 . | ≥ 50 . | ||||||
| Mean | 45 (28-62) | 19 (10-28) | .0107* | ||||
| < 24, n | 5 | 18 | |||||
| ≥ 24, n | 9 | 5 | |||||
| No. of newborns | 14 | 23 | .0153* | 64.3 | 78.3 | 64.3 | 78.3 |
| Weighted AUC, IU/mL per wks of gestation . | Newborn platelet count, × 109/L (95% CI) . | P . | Sensitivity, % . | Specificity, % . | PPV, % . | NPV, % . | |
|---|---|---|---|---|---|---|---|
| < 50 . | ≥ 50 . | ||||||
| Mean | 45 (28-62) | 19 (10-28) | .0107* | ||||
| < 24, n | 5 | 18 | |||||
| ≥ 24, n | 9 | 5 | |||||
| No. of newborns | 14 | 23 | .0153* | 64.3 | 78.3 | 64.3 | 78.3 |
Weighted AUC and newborn platelet counts at delivery of 34 IVIG-treated pregnancies (37 newborns).
CI indicates confidence interval; PPV, positive predictive value; and NPV, negative predictive value.
P < .05 (CI for α-risk of 5%).