Response to therapy according to the antenatal management
| Parameter/treatment category . | Value . | P . |
|---|---|---|
| No. of women/pregnancies/newborns | ||
| A | 66/66/66 | |
| B | 11/11/11 | |
| C | 23/27/27 | |
| D | 46/51/54 | |
| No. of intracranial hemorrhage | ||
| A | 9 | |
| B | 0 | |
| C | 0 | |
| D | 0 | |
| No. of newborns with severe thrombocytopenia (< 50 × 109/L platelets) | ||
| A | 54 (82%) | |
| B | 8 (73%) | A/B: .4398 |
| C | 12 (44%) | A/C: .0003* |
| D | 13 (27%) | A/D: < .0001*; B/D: .0044* |
| Mean newborn platelet count, × 109/L (95% CI) | ||
| A | 23 (18-28) (n = 66) | |
| B | 46 (21-71) (n = 11) | A/B: .0074* |
| C | 89 (55-123) (n = 27) | A/C: < .0001* |
| D | 135 (108-158) (n = 54) | A/D: < .0001* |
| No. of newborns who received a postnatal treatment | ||
| A | 42 (79%) | |
| B | 7 (64%) | A/B: .2682 |
| C | 16 (59%) | A/C: .0691 |
| D | 14 (26%) | A/D: < .0001*; B/D: .0295*; C/D: .0066* |
| Parameter/treatment category . | Value . | P . |
|---|---|---|
| No. of women/pregnancies/newborns | ||
| A | 66/66/66 | |
| B | 11/11/11 | |
| C | 23/27/27 | |
| D | 46/51/54 | |
| No. of intracranial hemorrhage | ||
| A | 9 | |
| B | 0 | |
| C | 0 | |
| D | 0 | |
| No. of newborns with severe thrombocytopenia (< 50 × 109/L platelets) | ||
| A | 54 (82%) | |
| B | 8 (73%) | A/B: .4398 |
| C | 12 (44%) | A/C: .0003* |
| D | 13 (27%) | A/D: < .0001*; B/D: .0044* |
| Mean newborn platelet count, × 109/L (95% CI) | ||
| A | 23 (18-28) (n = 66) | |
| B | 46 (21-71) (n = 11) | A/B: .0074* |
| C | 89 (55-123) (n = 27) | A/C: < .0001* |
| D | 135 (108-158) (n = 54) | A/D: < .0001* |
| No. of newborns who received a postnatal treatment | ||
| A | 42 (79%) | |
| B | 7 (64%) | A/B: .2682 |
| C | 16 (59%) | A/C: .0691 |
| D | 14 (26%) | A/D: < .0001*; B/D: .0295*; C/D: .0066* |
Treatment category A includes the index cases (n = 62) and 4 untreated subsequent pregnancies; category B, steroids alone; category C, IVIG; and category D, IVIG plus steroids.
CI indicates confidence interval.
P < .05.