Characteristics of 100 cases of MPAL
| . | B + My . | T + My . | B + T . | B + T + My . | Total . |
|---|---|---|---|---|---|
| Cases, n (%) | 59 (58%) | 35 (36%) | 4 (4%) | 2 (2%) | 100 |
| Age, c/a | 18/38 | 6/27 | 3/1 | 0/2 | 27/68 |
| Sex, M/F | 35/24 | 22/12 | 3/1 | 1/1 | 62/38 |
| ALL | 25 | 8 | 4 | 2 | 39 |
| AML | 22 | 15 | 0 | 0 | 38 |
| AUL | 7 | 6 | 0 | 0 | 13 |
| MPO | 55* | 35 | 0 | 2 | |
| CytCD3 | 0 | 35 | 4 | 2 | |
| CD19 | 54† | 0 | 4 | 2 | |
| CD10 | 33/53 | 4/25 | 3 | 1 | |
| CytCD22 | 45/54 | 0 | 2 | 2 | |
| CD79a | 34/38 | 4/15 | 2/2 | 1 |
| . | B + My . | T + My . | B + T . | B + T + My . | Total . |
|---|---|---|---|---|---|
| Cases, n (%) | 59 (58%) | 35 (36%) | 4 (4%) | 2 (2%) | 100 |
| Age, c/a | 18/38 | 6/27 | 3/1 | 0/2 | 27/68 |
| Sex, M/F | 35/24 | 22/12 | 3/1 | 1/1 | 62/38 |
| ALL | 25 | 8 | 4 | 2 | 39 |
| AML | 22 | 15 | 0 | 0 | 38 |
| AUL | 7 | 6 | 0 | 0 | 13 |
| MPO | 55* | 35 | 0 | 2 | |
| CytCD3 | 0 | 35 | 4 | 2 | |
| CD19 | 54† | 0 | 4 | 2 | |
| CD10 | 33/53 | 4/25 | 3 | 1 | |
| CytCD22 | 45/54 | 0 | 2 | 2 | |
| CD79a | 34/38 | 4/15 | 2/2 | 1 |
See text for the expression of other antigens.
MPAL indicates mixed-phenotype acute leukemia; c/a, children/adults, ; M, male; F, female; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; AUL, undifferentiated acute leukemia; SBB, Sudan black B; and MPO, myeloperoxidase.
Four cases not tested but they were MPO and SBB positive by cytochemistry.
Blasts from the 5 CD19-negative cases strongly expressed 2 or 3 B-lymphoid–associated markers.