Summary of Notch1 mutations in LHP tumors (4 of 25 analyzed)
| Tumor . | Phenotype . | HD exon 26 . | HD exon 27 . | 25% PEST . | 75% PEST . | Amino acid change . |
|---|---|---|---|---|---|---|
| LHP 16 | DP, CD4 SP, CD8 SP, DN | None | None | None | Deletion 7535-GCAGTCTGCCTGTGCACACCATTCTGCCCCAGGAAAGCCAGGCCCTGCCCACATCACTGCCATCCTCCATGGTCCCA-7611 | Frameshift and premature stop codon |
| LHP 667 | DN, CD8 SP | None | None | None | Deletion 7527-TACAACCGCTGGGCCCCAGCAGTCTG-7552 | Frameshift and premature stop codon |
| LHP 661 | DN | None | None | None | Insertion 7717-C | Frameshift and premature stop codon |
| LHP 313 | CD8 SP | None | None | 7346- G → CA | None | Frameshift and premature stop codon |
| Tumor . | Phenotype . | HD exon 26 . | HD exon 27 . | 25% PEST . | 75% PEST . | Amino acid change . |
|---|---|---|---|---|---|---|
| LHP 16 | DP, CD4 SP, CD8 SP, DN | None | None | None | Deletion 7535-GCAGTCTGCCTGTGCACACCATTCTGCCCCAGGAAAGCCAGGCCCTGCCCACATCACTGCCATCCTCCATGGTCCCA-7611 | Frameshift and premature stop codon |
| LHP 667 | DN, CD8 SP | None | None | None | Deletion 7527-TACAACCGCTGGGCCCCAGCAGTCTG-7552 | Frameshift and premature stop codon |
| LHP 661 | DN | None | None | None | Insertion 7717-C | Frameshift and premature stop codon |
| LHP 313 | CD8 SP | None | None | 7346- G → CA | None | Frameshift and premature stop codon |