Tryptase and MITF are coexpressed in patients with systemic mastocytosis and c-KIT mutations
Patient no. . | Diagnosis . | . | Staining . | |
---|---|---|---|---|
Tryptase . | MITF . | |||
1 | Indolent systemic mastocytosis | D816V | ++ | + |
2 | Indolent systemic mastocytosis | D816V | ++ | + |
3 | Indolent systemic mastocytosis | D816V | ++ | + |
4 | Indolent systemic mastocytosis | D816V | ++ | + |
5 | Indolent systemic mastocytosis | D816V | ++ | + |
6 | Indolent systemic mastocytosis | D816V | ++ | + |
7 | Indolent systemic mastocytosis | D816V | ++ | + |
8 | Indolent systemic mastocytosis | D816V | ++ | + |
9 | Systemic mastocytosis | F522C | ++ | + |
10 | Aggressive systemic mastocytosis | D816Y | ++ | − |
11 | Aplastic anemia | NT | ++ | − |
12 | Aplastic anemia | NT | ++ | − |
13 | Aplastic anemia | NT | ++ | − |
14 | Aplastic anemia | NT | ++ | − |
15 | Aplastic anemia | NT | ++ | − |
16 | Aplastic anemia | NT | ++ | − |
17 | Aplastic anemia | NT | ++ | − |
18 | Fanconi anemia | NT | ++ | − |
19 | Acute lymphoblastic leukemia | NT | ++ | − |
20 | Hemophagocytic lymphohistiocytosis | NT | ++ | − |
Patient no. . | Diagnosis . | . | Staining . | |
---|---|---|---|---|
Tryptase . | MITF . | |||
1 | Indolent systemic mastocytosis | D816V | ++ | + |
2 | Indolent systemic mastocytosis | D816V | ++ | + |
3 | Indolent systemic mastocytosis | D816V | ++ | + |
4 | Indolent systemic mastocytosis | D816V | ++ | + |
5 | Indolent systemic mastocytosis | D816V | ++ | + |
6 | Indolent systemic mastocytosis | D816V | ++ | + |
7 | Indolent systemic mastocytosis | D816V | ++ | + |
8 | Indolent systemic mastocytosis | D816V | ++ | + |
9 | Systemic mastocytosis | F522C | ++ | + |
10 | Aggressive systemic mastocytosis | D816Y | ++ | − |
11 | Aplastic anemia | NT | ++ | − |
12 | Aplastic anemia | NT | ++ | − |
13 | Aplastic anemia | NT | ++ | − |
14 | Aplastic anemia | NT | ++ | − |
15 | Aplastic anemia | NT | ++ | − |
16 | Aplastic anemia | NT | ++ | − |
17 | Aplastic anemia | NT | ++ | − |
18 | Fanconi anemia | NT | ++ | − |
19 | Acute lymphoblastic leukemia | NT | ++ | − |
20 | Hemophagocytic lymphohistiocytosis | NT | ++ | − |
+ indicates positive staining ++, strongly positive staining −, no detectable staining and — NT, not tested.