Risk factors for second solid cancers among allogeneic HCT recipients of high-dose Bu-Cy conditioning for AML in CR1 and CML in CP1
| Risk factor . | N . | Relative risk (95% CI) . | P . |
|---|---|---|---|
| Age at transplantation | |||
| < 35 y | 2218 | 1.0 | < .001 |
| 35-50 y | 1643 | 3.1 (1.6-5.9) | < .001 |
| > 50 y | 361 | 9.8 (4.8-20.0) | < .001 |
| Karnofsky performance score at HCT | |||
| < 90 | 471 | 1.00 | .026 |
| ≥ 90 | 3713 | 0.4 (0.2-0.8) | .004 |
| Unknown | 38 | 0.7 (0.1-5.6) | .767 |
| Chronic GVHD | |||
| No | 2549 | 1.00 | .001 |
| Yes | 1679 | 2.4 (1.4-4.2) |
| Risk factor . | N . | Relative risk (95% CI) . | P . |
|---|---|---|---|
| Age at transplantation | |||
| < 35 y | 2218 | 1.0 | < .001 |
| 35-50 y | 1643 | 3.1 (1.6-5.9) | < .001 |
| > 50 y | 361 | 9.8 (4.8-20.0) | < .001 |
| Karnofsky performance score at HCT | |||
| < 90 | 471 | 1.00 | .026 |
| ≥ 90 | 3713 | 0.4 (0.2-0.8) | .004 |
| Unknown | 38 | 0.7 (0.1-5.6) | .767 |
| Chronic GVHD | |||
| No | 2549 | 1.00 | .001 |
| Yes | 1679 | 2.4 (1.4-4.2) |