Table 3 Univariate and multivariate... | American Society of Hematology

Table 3

Univariate and multivariate analysis (Cox model) of overall survival

	Univariate			Multivariate
	HR	95% CI	P	HR	95% CI	P
Response*			< .001			< .001
CR vs VGPR	0.15	0.08-0.28	< .001	0.25	0.11-0.55	.001
CR vs PR	0.08	0.04-0.16	< .001	0.16	0.06-0.39	< .001
CR vs SD	0.03	0.01-0.06	< .001	0.07	0.02-0.20	< .001
CR vs PD	0.01	0.005-0.03	< .001	0.03	0.009-0.11	< .001
Age, y
> 75 vs ≤ 75	1.59	1.29-1.96	< .001	1.30	1.00-1.70	.053
ISS			< .001			< .001
II vs I	1.73	1.24-2.43	.001	1.41	0.99-2.01	.056
III vs I	2.84	2.00-4.04	< .001	2.17	1.49-3.15	< .001
Durie and Salmon stage
III vs II	1.38	1.10-1.73	.006	1.38	1.04-1.82	.024
Therapy			< .001			.003
MPT vs MP	0.88	0.71-1.10	.263	1.00	0.76-1.31	.991
VMP vs MP	0.25	0.17-0.38	< .001	0.30	0.14-0.64	.002
VMPT-VT vs MP	0.23	0.15-0.36	< .001	0.50	0.26-0.95	.035

	Univariate			Multivariate
	HR	95% CI	P	HR	95% CI	P
Response*			< .001			< .001
CR vs VGPR	0.15	0.08-0.28	< .001	0.25	0.11-0.55	.001
CR vs PR	0.08	0.04-0.16	< .001	0.16	0.06-0.39	< .001
CR vs SD	0.03	0.01-0.06	< .001	0.07	0.02-0.20	< .001
CR vs PD	0.01	0.005-0.03	< .001	0.03	0.009-0.11	< .001
Age, y
> 75 vs ≤ 75	1.59	1.29-1.96	< .001	1.30	1.00-1.70	.053
ISS			< .001			< .001
II vs I	1.73	1.24-2.43	.001	1.41	0.99-2.01	.056
III vs I	2.84	2.00-4.04	< .001	2.17	1.49-3.15	< .001
Durie and Salmon stage
III vs II	1.38	1.10-1.73	.006	1.38	1.04-1.82	.024
Therapy			< .001			.003
MPT vs MP	0.88	0.71-1.10	.263	1.00	0.76-1.31	.991
VMP vs MP	0.25	0.17-0.38	< .001	0.30	0.14-0.64	.002
VMPT-VT vs MP	0.23	0.15-0.36	< .001	0.50	0.26-0.95	.035

SD indicates stable disease; and PD, progressive disease.

Treated as a time-dependent variable.