Table 1

History of the classification of LGL leukemia

FAB (1989)REAL (1994)WHO (1999)WHO (2008)
Chronic T lymphoid leukemias T-cell and putative NK-cell neoplasms Mature (peripheral) T-cell neoplasms Mature T-cell and NK-cell neoplasms 
T-cell CLL or LGL leukemia T-cell chronic lymphocytic leukemia/prolymphocytic T-cell granular lymphocytic leukemia T-cell granular lymphocytic leukemia 
T prolymphocytic leukemia LGL leukemia Aggressive NK-cell leukemia Chronic lymphoproliferative disorder of NK cells* 
 T-cell type   
Adult T-cell leukemia/ lymphoma NK-cell type   
Sezary syndrome   Aggressive NK-cell leukemia 
FAB (1989)REAL (1994)WHO (1999)WHO (2008)
Chronic T lymphoid leukemias T-cell and putative NK-cell neoplasms Mature (peripheral) T-cell neoplasms Mature T-cell and NK-cell neoplasms 
T-cell CLL or LGL leukemia T-cell chronic lymphocytic leukemia/prolymphocytic T-cell granular lymphocytic leukemia T-cell granular lymphocytic leukemia 
T prolymphocytic leukemia LGL leukemia Aggressive NK-cell leukemia Chronic lymphoproliferative disorder of NK cells* 
 T-cell type   
Adult T-cell leukemia/ lymphoma NK-cell type   
Sezary syndrome   Aggressive NK-cell leukemia 
*

Provisional entity.

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