Analysis of factors associated with PFS in the intent-to-treat population (N = 482)
| Variable . | Total patients evaluable . | Median PFS, mo (range) . | Relative risk (95% CI) . | P . |
|---|---|---|---|---|
| Univariate analysis | ||||
| Hemoglobin, < 10 g/dL | 480 | 30.9 (25.5-not reached) | 1.2 (0.9-1.5) | .2088 |
| t(4;14) and/or del(17p) | 482 | 26.4 (20.2-36.0) | 1.5 (1.0-2.2) | .0313 |
| Best response to therapy less than VGPR | 482 | 27.9 (23.6-33.2) | 1.7 (1.1-2.6) | .009 |
| β 2-microglobulin > 3 mg/L | 482 | 29.7 (24.4-33.5) | 1.7 (1.3-2.2) | .0001 |
| ISS stage 1 vs 2 and 3 | 468 | 28.8 (24.4-33.2) | 1.8 (1.4-2.4) | <.0001 |
| Response induction less than VGPR | 482 | 29.0 (26.4-33.5) | 2.2 (1.5-3.0) | <.0001 |
| Multivariate analysis | ||||
| t(4;14) and/or del(17p) | 1.5 (1.0-2.1) | .0621 | ||
| ISS stage 1 vs 2 and 3 | 1.8 (1.4-2.4) | <.0001 | ||
| Best response to therapy less than VGPR | 2.0 (1.5-2.7) | <.0001 | ||
| Response to induction less than VGPR | 2.3 (1.6-3.2) | <.0001 |
| Variable . | Total patients evaluable . | Median PFS, mo (range) . | Relative risk (95% CI) . | P . |
|---|---|---|---|---|
| Univariate analysis | ||||
| Hemoglobin, < 10 g/dL | 480 | 30.9 (25.5-not reached) | 1.2 (0.9-1.5) | .2088 |
| t(4;14) and/or del(17p) | 482 | 26.4 (20.2-36.0) | 1.5 (1.0-2.2) | .0313 |
| Best response to therapy less than VGPR | 482 | 27.9 (23.6-33.2) | 1.7 (1.1-2.6) | .009 |
| β 2-microglobulin > 3 mg/L | 482 | 29.7 (24.4-33.5) | 1.7 (1.3-2.2) | .0001 |
| ISS stage 1 vs 2 and 3 | 468 | 28.8 (24.4-33.2) | 1.8 (1.4-2.4) | <.0001 |
| Response induction less than VGPR | 482 | 29.0 (26.4-33.5) | 2.2 (1.5-3.0) | <.0001 |
| Multivariate analysis | ||||
| t(4;14) and/or del(17p) | 1.5 (1.0-2.1) | .0621 | ||
| ISS stage 1 vs 2 and 3 | 1.8 (1.4-2.4) | <.0001 | ||
| Best response to therapy less than VGPR | 2.0 (1.5-2.7) | <.0001 | ||
| Response to induction less than VGPR | 2.3 (1.6-3.2) | <.0001 |
ISS indicates International Staging System; PFS, progression-free survival; and VGPR, very good partial response.