Summary of outcome data by type of regimen
| Intervention . | No. of patients treated at URI . | No. (%) progressed to LRI . | No. (%) not treated at URI . | No. (%) progressed to LRI . | P . | OR (95% CI) . | No. (%) of patients treated at LRI . | No. (%) of deaths . | No. of patients not treated at LRI . | No. (%) of deaths . | P . | OR (95% CI) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AR alone | 44 | 11 (25) | 116 | 54 (47) | .01 | 2.6 (1.2-5.7) | 56 | 28 (50) | 9 | 8 (89) | .04 | 8.0 (0.9-68.3) |
| AR + immunomodulator | 95 | 11 (12) | 174 | 78 (45) | < .001 | 6.2 (3.1-12.4) | 136 | 33 (24) | 22 | 17 (77) | < .001 | 10.6 (3.6-31.0) |
| IR/OR ± immunomodulator | 22 | 4 (18) | 52 | 18 (35) | .16 | 2.4 (0.7-8.1) | 48 | 26 (54) | 4 | 3 (75) | .62 | 2.5 (0.2-26.2) |
| Total | ||||||||||||
| Total before adding 3 studies where outcome is available only for treated vs untreated | 161 | 26 (16) | 342 | 150 (44) | < .001 | 4.1 (2.5-6.5) | 240 | 87 (36) | 35 | 28 (80) | < .001 | 7.0 (2.9-16.8) |
| Total after adding 3 studies where outcome is available only for treated vs untreated | 185 | 30 (16) | 360 | 161 (45) | < .001 | 4.2 (2.7-6.5) | 265 | 94 (35) | 43 | 30 (70) | < .001 | 4.2 (2.1-8.4) |
| Intervention . | No. of patients treated at URI . | No. (%) progressed to LRI . | No. (%) not treated at URI . | No. (%) progressed to LRI . | P . | OR (95% CI) . | No. (%) of patients treated at LRI . | No. (%) of deaths . | No. of patients not treated at LRI . | No. (%) of deaths . | P . | OR (95% CI) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AR alone | 44 | 11 (25) | 116 | 54 (47) | .01 | 2.6 (1.2-5.7) | 56 | 28 (50) | 9 | 8 (89) | .04 | 8.0 (0.9-68.3) |
| AR + immunomodulator | 95 | 11 (12) | 174 | 78 (45) | < .001 | 6.2 (3.1-12.4) | 136 | 33 (24) | 22 | 17 (77) | < .001 | 10.6 (3.6-31.0) |
| IR/OR ± immunomodulator | 22 | 4 (18) | 52 | 18 (35) | .16 | 2.4 (0.7-8.1) | 48 | 26 (54) | 4 | 3 (75) | .62 | 2.5 (0.2-26.2) |
| Total | ||||||||||||
| Total before adding 3 studies where outcome is available only for treated vs untreated | 161 | 26 (16) | 342 | 150 (44) | < .001 | 4.1 (2.5-6.5) | 240 | 87 (36) | 35 | 28 (80) | < .001 | 7.0 (2.9-16.8) |
| Total after adding 3 studies where outcome is available only for treated vs untreated | 185 | 30 (16) | 360 | 161 (45) | < .001 | 4.2 (2.7-6.5) | 265 | 94 (35) | 43 | 30 (70) | < .001 | 4.2 (2.1-8.4) |
OR indicates odds ratio; and CI, confidence interval.