Five-year cumulative risk and rate ratio of a hospitalized hemorrhage other than intracranial bleeding among 407 patients with cITP and 4069 members of the general population comparison cohort
| . | Five-year risk in patients with cITP, % (95% CI) . | Five-year risk in the comparison cohort, % (95% CI) . | Crude 5-year RR (95% CI) . | Adjusted 5-year RR (95% CI)* . |
|---|---|---|---|---|
| Total | 3.6 (2.1-5.8) | 1.1 (0.8-1.6) | 3.8 (2.0-6.9) | 4.4 (2.3-8.3) |
| Age at cITP diagnosis, y | ||||
| ≤ 60 | 3.4 (1.5-6.6) | 0.3 (0.1-0.6) | 14.4 (4.6-45.2) | 13.8 (4.4-43.4) |
| > 60 | 3.9 (1.7-7.4) | 2.3 (1.6-3.1) | 2.3 (1.0-5.2) | 2.6 (1.1-6.0) |
| Sex | ||||
| Female | 3.3 (1.5-6.1) | 0.9 (0.6-1.4) | 4.3 (1.9-9.6) | 6.0 (2.5-14.8) |
| Male | 4.2 (1.7-8.4) | 1.5 (1.0-2.4) | 3.3 (1.3-8.2) | 3.2 (1.3-8.2) |
| Year of cITP diagnosis | ||||
| 1996-2001 | 2.4 (0.8-5.6) | 0.8 (0.5-1.4) | 3.0 (1.0-9.1) | 3.5 (1.1-11.3) |
| 2002-2007 | 4.4 (2.2-7.6) | 1.4 (0.9-2.1) | 4.2 (2.0-8.8) | 4.9 (2.3-10.4) |
| Comorbidity score | ||||
| 0 | 2.6 (1.1-5.2) | 0.5 (0.3-0.9) | 5.6 (2.1-15.2) | 5.8 (2.1-16.0) |
| ≥ 1 | 5.2 (2.4-9.5) | 2.2 (1.5-3.0) | 3.2 (1.5-7.0) | 3.7 (1.6-8.4) |
| . | Five-year risk in patients with cITP, % (95% CI) . | Five-year risk in the comparison cohort, % (95% CI) . | Crude 5-year RR (95% CI) . | Adjusted 5-year RR (95% CI)* . |
|---|---|---|---|---|
| Total | 3.6 (2.1-5.8) | 1.1 (0.8-1.6) | 3.8 (2.0-6.9) | 4.4 (2.3-8.3) |
| Age at cITP diagnosis, y | ||||
| ≤ 60 | 3.4 (1.5-6.6) | 0.3 (0.1-0.6) | 14.4 (4.6-45.2) | 13.8 (4.4-43.4) |
| > 60 | 3.9 (1.7-7.4) | 2.3 (1.6-3.1) | 2.3 (1.0-5.2) | 2.6 (1.1-6.0) |
| Sex | ||||
| Female | 3.3 (1.5-6.1) | 0.9 (0.6-1.4) | 4.3 (1.9-9.6) | 6.0 (2.5-14.8) |
| Male | 4.2 (1.7-8.4) | 1.5 (1.0-2.4) | 3.3 (1.3-8.2) | 3.2 (1.3-8.2) |
| Year of cITP diagnosis | ||||
| 1996-2001 | 2.4 (0.8-5.6) | 0.8 (0.5-1.4) | 3.0 (1.0-9.1) | 3.5 (1.1-11.3) |
| 2002-2007 | 4.4 (2.2-7.6) | 1.4 (0.9-2.1) | 4.2 (2.0-8.8) | 4.9 (2.3-10.4) |
| Comorbidity score | ||||
| 0 | 2.6 (1.1-5.2) | 0.5 (0.3-0.9) | 5.6 (2.1-15.2) | 5.8 (2.1-16.0) |
| ≥ 1 | 5.2 (2.4-9.5) | 2.2 (1.5-3.0) | 3.2 (1.5-7.0) | 3.7 (1.6-8.4) |
cITP indicates chronic immune thrombocytopenia; CI, confidence interval; and RR, rate ratio.
Adjusted for age (≤ 60 years and > 60 years), sex, calendar year, and level of comorbidity.