Th17 and Treg numbers in 40 patients with and without clinical or pathologic digestive GVHD (first cohort)
| . | Total (n = 40) . | GVHD clinical (final diagnosis) . | GVHD pathologically proven . | ||||
|---|---|---|---|---|---|---|---|
| No (n = 6) . | Yes (n = 34) . | No (n = 6) . | Yes (n = 34) . | Grade 0-1 (n = 22) . | Grade 2-4 (n = 18) . | ||
| Th17, median (range) | 1.0 (0-8) | 5.5 (1-8) | 1.0 (0-7) | 5.5 (4-8) | 1.0 (0-7) | 2.0 (0-8) | 0.5 (0-4) |
| Treg, median (range) | 4.0 (0-11) | 0.0 (0-1) | 5.0 (0-11) | 0.0 (0-3) | 5.0 (0-11) | 2.0 (0-6) | 6.5 (0-11) |
| Th17/Treg,* median (range) | 0.5 (0.05-16) | 9.0 (2-16) | 0.4 (0.05-10) | 10 (2.3-16) | 0.4 (0.05-6) | 1.5 (0.13-16) | 0.1 (0.05-4) |
| Th17/Treg < 1, n (%) | 25 (63%) | 0 (0%) | 25 (74%) | 0 (0%) | 25 (74%) | 8 (36%) | 17 (94%) |
| . | Total (n = 40) . | GVHD clinical (final diagnosis) . | GVHD pathologically proven . | ||||
|---|---|---|---|---|---|---|---|
| No (n = 6) . | Yes (n = 34) . | No (n = 6) . | Yes (n = 34) . | Grade 0-1 (n = 22) . | Grade 2-4 (n = 18) . | ||
| Th17, median (range) | 1.0 (0-8) | 5.5 (1-8) | 1.0 (0-7) | 5.5 (4-8) | 1.0 (0-7) | 2.0 (0-8) | 0.5 (0-4) |
| Treg, median (range) | 4.0 (0-11) | 0.0 (0-1) | 5.0 (0-11) | 0.0 (0-3) | 5.0 (0-11) | 2.0 (0-6) | 6.5 (0-11) |
| Th17/Treg,* median (range) | 0.5 (0.05-16) | 9.0 (2-16) | 0.4 (0.05-10) | 10 (2.3-16) | 0.4 (0.05-6) | 1.5 (0.13-16) | 0.1 (0.05-4) |
| Th17/Treg < 1, n (%) | 25 (63%) | 0 (0%) | 25 (74%) | 0 (0%) | 25 (74%) | 8 (36%) | 17 (94%) |
Fisher exact test for the association of Th17/Treg < 1 with the other pathologic parameters.