Table 2 Differential mRNA expression in... | American Society of Hematology

Table 2

Differential mRNA expression in DLBCL with 9p21 locus deletion

GCB/ABC DLBCL (n = 52)						ABC DLBCL (n = 39)
Genes with increased expression	logFC	Adjusted P	Gene with decreased expression	logFC	Adjusted P	Gene with increased expression	logFC	Adjusted P	Gene with decreased expression	logFC	Adjusted P
ACY1*	.61	.01	AIM1*	−1.01	.01	ACADM	.68	.05	ADD1	−.37	.03
ARMCX2	1.18	.02	ANXA4	−.90	.03	ACTL6A	.52	.04	ARAP1†	−.30	.03
BCL2*	.44	.04	ATP10D	−.71	.04	ACY1	.65	.03	C1orf38	−.97	.05
BIK*	1.41	.02	CHFR	−.64	.03	APEX1	.46	.02	CTNND1†	−.36	.02
BLNK*	.89	.02	DEGS1	−.58	.03	CBX3	.48	.02	EDEM2	−.37	.05
BSPRY	.70	.02	DGKZ	−.56	.02	CCDC72	.39	.04	EHBP1L1	−.44	.05
C13ORF18	1.37	.02	EHD4	−.50	.04	CISD1	.71	.02	FLII	−.47	.00
C3ORF60	.40	.02	EPS15	−.66	.04	DALRD3	.43	.02	FLNA	−.63	.03
CBX3	.39	.05	FAM49A	−.80	.05	EEF1B2†	.52	.00	GALNT10	−.48	.02
DALRD3	.41	.02	FYB	−.81	.04	EI24	.45	.02	GSDMD	−.30	.02
DBN1	.48	.02	GALNT10	−.45	.03	EIF3E	.43	.02	HCRP1	−.41	.04
DLAT	.61	.03	IDS	−.80	.03	ERH	.38	.03	IDUA	−.33	.04
FUT8*	.83	.01	IL1R1	−.95	.02	EXOSC7	.45	.02	INPP1	−.52	.03
GNL3	.64	.02	ITGAL	−.65	.02	GNL3	.75	.02	ITGAL	−.66	.02
GOT2	.71	.03	LCP2	−.90	.04	IFRD2	.50	.03	MACF1	−.64	.02
HIST2H4B	.56	.05	LIMS1	−.78	.02	IGF2BP3*†	1.47	.01	MVP	−.59	.03
HMBS	.40	.04	LMO4	−.82	.05	IMPDH2	.96	.00	MYH9	−.50	.02
IGF2BP3*	1.12	.02	LYST	−.79	.03	IPO5	.54	.04	NOTCH2NL	−.68	.04
IMPDH2*	.75	.01	MACF1	−.74	.03	KIF15	.69	.03	NPDC1	−.47	.02
KIF15	.61	.03	PARP12	−.69	.02	LOC10013062	.78	.00	NRBP1†	−.44	.00
LIMD1	.53	.03	PDLIM5	−.56	.03	LSM3	.61	.01	PARP12	−.65	.05
LOC283412	.47	.03	PDXK*	−.53	.03	MFN1†	.66	.05	PIP5K1C	−.41	.03
LSM3	.47	.02	PLA2G4C	−.53	.04	MGC3196	.23	.04	PLEKHO2	−.54	.02
MCM2	.76	.02	PPAP2B*	−.73	.04	MGC39900	.54	.02	PPAP2B	−.82	.03
TMSB15B	.75	.01	PSTPIP1	−.50	.04	MTX1	.32	.04	PSEN2	−.55	.02
MFN1	.58	.03	RALGDS	−.57	.04	NARS2	.45	.04	PSTPIP1	−.53	.05
MGC39900	.49	.01	RASGRP1	−.96	.03	NHP2	.47	.04	SELPLG	−.72	.04
NPM3	.47	.04	RNF19B	−.75	.03	NLE1	.42	.02	SHC1	−.37	.02
PHACTR1	1.08	.00	RRAGA	−.67	.02	PHACTR1†	1.10	.02	SLC25A44	−.32	.02
PKIG	.68	.03	RSU1	−.52	.03	PKIG†	.84	.05	SNTB2	−.44	.04
RANBP5	.46	.03	SELPLG	−.72	.03	QARS	.56	.00	ST3GAL1	−.25	.04
RASAL1	.49	.04	SEPW1	−.59	.04	RAD51L1*	.39	.01	TGOLN2	−.42	.04
RASGRF1*	.77	.03	SH3GLB1	−.46	.04	RPL10A	.33	.04	TNFRSF1A	−.51	.03
RBBP8	.56	.03	TIAM1	−1.09	.02	RPL14 /// RPL	.56	.00	TNFRSF6	−.89	.04
RMI1*	.52	.04	TNFRSF1A	−.50	.03	RPL15*†	.51	.02	TRADD	−.31	.04
RPL15*	.68	.00	TNFRSF6*	−1.10	.00	RPL24†	.51	.00	TRPV2†	−.49	.02
RPL35A	.39	.03	TNIP2	−.49	.04	RPL32	.32	.02	UNC84B	−.36	.05
RUVBL1	.57	.02	TRPV2	−.54	.03	RPL35A	.48	.02	UPP1*†	−.63	.02
SH3BP5	.83	.02	UPP1*	−.77	.02	RPL4	.39	.02	ZDHHC18	−.30	.04
SMARCC1	.45	.04	VIM	−.49	.04	RPS13	.33	.00	ZZEF1	−.32	.02
SNRPD1	.59	.03	VPS37B	−.56	.05	RPS15A	.22	.04
TBL1XR1	.99	.01	WDR45	−.59	.03	RPS17L4	.44	.02
TCF4	.90	.02				RSL1D1†	.48	.01
TMEM97*	.74	.02				RUVBL1	.65	.03
						SEPT7	.45	.02
						SMARCC1	.57	.02
						SUCLG2	.60	.03
						TBL1XR1†	1.09	.01
						TIMM9	.48	.01
						TMEM97	.90	.02
						UQCRH	.66	.02
						VRK1	.57	.04

GCB/ABC DLBCL (n = 52)						ABC DLBCL (n = 39)
Genes with increased expression	logFC	Adjusted P	Gene with decreased expression	logFC	Adjusted P	Gene with increased expression	logFC	Adjusted P	Gene with decreased expression	logFC	Adjusted P
ACY1*	.61	.01	AIM1*	−1.01	.01	ACADM	.68	.05	ADD1	−.37	.03
ARMCX2	1.18	.02	ANXA4	−.90	.03	ACTL6A	.52	.04	ARAP1†	−.30	.03
BCL2*	.44	.04	ATP10D	−.71	.04	ACY1	.65	.03	C1orf38	−.97	.05
BIK*	1.41	.02	CHFR	−.64	.03	APEX1	.46	.02	CTNND1†	−.36	.02
BLNK*	.89	.02	DEGS1	−.58	.03	CBX3	.48	.02	EDEM2	−.37	.05
BSPRY	.70	.02	DGKZ	−.56	.02	CCDC72	.39	.04	EHBP1L1	−.44	.05
C13ORF18	1.37	.02	EHD4	−.50	.04	CISD1	.71	.02	FLII	−.47	.00
C3ORF60	.40	.02	EPS15	−.66	.04	DALRD3	.43	.02	FLNA	−.63	.03
CBX3	.39	.05	FAM49A	−.80	.05	EEF1B2†	.52	.00	GALNT10	−.48	.02
DALRD3	.41	.02	FYB	−.81	.04	EI24	.45	.02	GSDMD	−.30	.02
DBN1	.48	.02	GALNT10	−.45	.03	EIF3E	.43	.02	HCRP1	−.41	.04
DLAT	.61	.03	IDS	−.80	.03	ERH	.38	.03	IDUA	−.33	.04
FUT8*	.83	.01	IL1R1	−.95	.02	EXOSC7	.45	.02	INPP1	−.52	.03
GNL3	.64	.02	ITGAL	−.65	.02	GNL3	.75	.02	ITGAL	−.66	.02
GOT2	.71	.03	LCP2	−.90	.04	IFRD2	.50	.03	MACF1	−.64	.02
HIST2H4B	.56	.05	LIMS1	−.78	.02	IGF2BP3*†	1.47	.01	MVP	−.59	.03
HMBS	.40	.04	LMO4	−.82	.05	IMPDH2	.96	.00	MYH9	−.50	.02
IGF2BP3*	1.12	.02	LYST	−.79	.03	IPO5	.54	.04	NOTCH2NL	−.68	.04
IMPDH2*	.75	.01	MACF1	−.74	.03	KIF15	.69	.03	NPDC1	−.47	.02
KIF15	.61	.03	PARP12	−.69	.02	LOC10013062	.78	.00	NRBP1†	−.44	.00
LIMD1	.53	.03	PDLIM5	−.56	.03	LSM3	.61	.01	PARP12	−.65	.05
LOC283412	.47	.03	PDXK*	−.53	.03	MFN1†	.66	.05	PIP5K1C	−.41	.03
LSM3	.47	.02	PLA2G4C	−.53	.04	MGC3196	.23	.04	PLEKHO2	−.54	.02
MCM2	.76	.02	PPAP2B*	−.73	.04	MGC39900	.54	.02	PPAP2B	−.82	.03
TMSB15B	.75	.01	PSTPIP1	−.50	.04	MTX1	.32	.04	PSEN2	−.55	.02
MFN1	.58	.03	RALGDS	−.57	.04	NARS2	.45	.04	PSTPIP1	−.53	.05
MGC39900	.49	.01	RASGRP1	−.96	.03	NHP2	.47	.04	SELPLG	−.72	.04
NPM3	.47	.04	RNF19B	−.75	.03	NLE1	.42	.02	SHC1	−.37	.02
PHACTR1	1.08	.00	RRAGA	−.67	.02	PHACTR1†	1.10	.02	SLC25A44	−.32	.02
PKIG	.68	.03	RSU1	−.52	.03	PKIG†	.84	.05	SNTB2	−.44	.04
RANBP5	.46	.03	SELPLG	−.72	.03	QARS	.56	.00	ST3GAL1	−.25	.04
RASAL1	.49	.04	SEPW1	−.59	.04	RAD51L1*	.39	.01	TGOLN2	−.42	.04
RASGRF1*	.77	.03	SH3GLB1	−.46	.04	RPL10A	.33	.04	TNFRSF1A	−.51	.03
RBBP8	.56	.03	TIAM1	−1.09	.02	RPL14 /// RPL	.56	.00	TNFRSF6	−.89	.04
RMI1*	.52	.04	TNFRSF1A	−.50	.03	RPL15*†	.51	.02	TRADD	−.31	.04
RPL15*	.68	.00	TNFRSF6*	−1.10	.00	RPL24†	.51	.00	TRPV2†	−.49	.02
RPL35A	.39	.03	TNIP2	−.49	.04	RPL32	.32	.02	UNC84B	−.36	.05
RUVBL1	.57	.02	TRPV2	−.54	.03	RPL35A	.48	.02	UPP1*†	−.63	.02
SH3BP5	.83	.02	UPP1*	−.77	.02	RPL4	.39	.02	ZDHHC18	−.30	.04
SMARCC1	.45	.04	VIM	−.49	.04	RPS13	.33	.00	ZZEF1	−.32	.02
SNRPD1	.59	.03	VPS37B	−.56	.05	RPS15A	.22	.04
TBL1XR1	.99	.01	WDR45	−.59	.03	RPS17L4	.44	.02
TCF4	.90	.02				RSL1D1†	.48	.01
TMEM97*	.74	.02				RUVBL1	.65	.03
						SEPT7	.45	.02
						SMARCC1	.57	.02
						SUCLG2	.60	.03
						TBL1XR1†	1.09	.01
						TIMM9	.48	.01
						TMEM97	.90	.02
						UQCRH	.66	.02
						VRK1	.57	.04

Results are obtained with Affymetrix U133A arrays from 52 ABC/GCB-DLBCL cases or 39 ABC-DLBCL cases. Classification is according to alphabetical order. Boldface indicates genes commonly found in the 9p21-related signature in the overall population and in the ABC subgroup. Signifcant adjusted P value (for multiple comparison) is less than .05.

DLBCL indicates, diffuse large B-cell lymphoma; GCB, germinal center B cell; ABC, activated B cell; and FC, fold change.

Genes that were studied by TLDAs in an independent set of patients.

†

Genes included in a set of 28 genes which classified ABC-DLBCL samples in two independent sets of ABC-DLBCL.

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