Characteristics of participants in the GWA scan discovery and replication samples in ARIC in 1987-1989
| Characteristic . | GWA scan discovery sample . | Replication sample . |
|---|---|---|
| N | 8048 | 1376 |
| Age, years | 54.3 ± 5.7 | 54.3 ± 5.7 |
| Female, % | 52.9 | 53.2 |
| Body mass index, kg/m2 | 27.0 | 26.7 |
| Prevalent coronary heart disease, % | 5.0 | 4.3 |
| Hypertension*, % | 27.0 | 24.9 |
| Diabetes†, % | 8.5 | 9.5 |
| Current smoker, % | 25.1 | 21.8 |
| Current alcohol drinker, % | 66.3 | 61.7 |
| Total cholesterol, mg/dL | 214.7 ± 40.7 | 215.7 ± 41.6 |
| Triglycerides, mg/dL | 137.1 ± 91.6 | 137.8 ± 94.9 |
| Protein C, μg/mL | 3.2 ± 0.6 | 3.2 ± 0.6 |
| Median protein C (IQR), μg/mL | 3.1 (2.8-3.5) | 3.1 (2.8-3.6) |
| Characteristic . | GWA scan discovery sample . | Replication sample . |
|---|---|---|
| N | 8048 | 1376 |
| Age, years | 54.3 ± 5.7 | 54.3 ± 5.7 |
| Female, % | 52.9 | 53.2 |
| Body mass index, kg/m2 | 27.0 | 26.7 |
| Prevalent coronary heart disease, % | 5.0 | 4.3 |
| Hypertension*, % | 27.0 | 24.9 |
| Diabetes†, % | 8.5 | 9.5 |
| Current smoker, % | 25.1 | 21.8 |
| Current alcohol drinker, % | 66.3 | 61.7 |
| Total cholesterol, mg/dL | 214.7 ± 40.7 | 215.7 ± 41.6 |
| Triglycerides, mg/dL | 137.1 ± 91.6 | 137.8 ± 94.9 |
| Protein C, μg/mL | 3.2 ± 0.6 | 3.2 ± 0.6 |
| Median protein C (IQR), μg/mL | 3.1 (2.8-3.5) | 3.1 (2.8-3.6) |
Data are stated as mean ± SD or percentage, unless otherwise stated.
Hypertension was defined based on systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg, or treatment for hypertension.
Diabetes defined as fasting glucose ≥ 126 mg/dL, nonfasting glucose ≥ 200 mg/dL, self-reported physician diagnosis of diabetes, or treatment for diabetes.