Mixed bone marrow chimeras do not develop an inflammatory phenotype in the peripheral blood
| . | Ratio of donor bone marrow cells implanted from control/KO mice . | ||||
|---|---|---|---|---|---|
| 100/0 . | 75/25 . | 50/50 . | 25/75 . | 0/100 . | |
| Granulocytes | 0.23 ± 0.04 | 0.25 ± 0.07 | 0.21 ± 0.03 | 0.31 ± 0.07 | 9.59 ± 6.3 |
| Inflammatory monocytes | 0.07 ± 0.02 | 0.06 ± 0.02 | 0.05 ± 0.02 | 0.09 ± 0.03 | 0.22 ± 0.14 |
| Resident monocytes | 0.20 ± 0.02 | 0.28 ± 0.09 | 0.20 ± 0.04 | 0.38 ± 0.14 | 0.1 ± 0.06 |
| B cells | 1.46 ± 0.28 | 2.22 ± 0.82 | 2.17 ± 0.60 | 5.21 ± 1.58 | 0.98 ± 0.43 |
| CD4+ T cells | 0.87 ± 0.13 | 1.02 ± 0.26 | 0.89 ± 0.15 | 1.66 ± 0.21 | 0.75 ± 0.14 |
| CD8+ T cells | 0.39 ± 0.04 | 0.45 ± 0.13 | 0.39 ± 0.07 | 0.82 ± 0.11 | 0.42 ± 0.05 |
| . | Ratio of donor bone marrow cells implanted from control/KO mice . | ||||
|---|---|---|---|---|---|
| 100/0 . | 75/25 . | 50/50 . | 25/75 . | 0/100 . | |
| Granulocytes | 0.23 ± 0.04 | 0.25 ± 0.07 | 0.21 ± 0.03 | 0.31 ± 0.07 | 9.59 ± 6.3 |
| Inflammatory monocytes | 0.07 ± 0.02 | 0.06 ± 0.02 | 0.05 ± 0.02 | 0.09 ± 0.03 | 0.22 ± 0.14 |
| Resident monocytes | 0.20 ± 0.02 | 0.28 ± 0.09 | 0.20 ± 0.04 | 0.38 ± 0.14 | 0.1 ± 0.06 |
| B cells | 1.46 ± 0.28 | 2.22 ± 0.82 | 2.17 ± 0.60 | 5.21 ± 1.58 | 0.98 ± 0.43 |
| CD4+ T cells | 0.87 ± 0.13 | 1.02 ± 0.26 | 0.89 ± 0.15 | 1.66 ± 0.21 | 0.75 ± 0.14 |
| CD8+ T cells | 0.39 ± 0.04 | 0.45 ± 0.13 | 0.39 ± 0.07 | 0.82 ± 0.11 | 0.42 ± 0.05 |
Data presented represent the number of cells × 103/μL determined by total cell count and flow cytometry, 8 weeks after bone marrow transplant. N = 5-6 in each group.