Table 1

Complete blood counts of Flipf/d, LysMc/+ and the littermate control mice

GenotypesNo. of Flip alleles in whole genome
No. of Flip alleles in myeloid lineage
2 alleles (Flip+/+, f/+, or f/f)LysM+/+1 allele (Flipd/+or f/d) >LysM+/+2 alleles (Flip+/+) LysMc/+1 allele (Flipd/+ or f/+) LysMc/+1-2 alleles (Flip+/+, f/+, or +/d) LysMc/c0 alleles (Flipf/d) LysMc/+
Number 11 8 5 25 9 56 
Leukocytes       
    White blood cells (103/μL) 9.3 ± 1.1‡ 11.7 ± 1.3† 9.9 ± 2.2‡ 11.8 ± 1.2† 12.6 ± 2.3‡ 58.8 ± 5.9 
    Neutrophils (103/μL) 2.6 ± 0.60‡ 2.8 ± 0.78† 2.2 ± 0.50* 2.6 ± 0.36‡ 2.6 ± 0.58‡ 33.9 ± 4.1 
    Lymphocytes (103/μL) 6.1 ± 0.8 7.9 ± 0.9 7.1 ± 1.8 7.4 ± 0.80 9.0 ± 1.5 13.9 ± 1.7 
    Monocytes (103/μL) 0.5 ± 0.18‡ 0.8 ± 0.2† 0.5 ± 0.2 0.7 ± 0.1‡ 0.80 ± 0.15† 8.9 ± 1.2 
    Eosinophila (103/μL) 0.2 ± 0.04* 0.2 ± 0.07 0.1 ± 0.07 0.2 ± 0.04‡ 0.19 ± 0.09 1.9 ± 0.3 
    Basophila (103/μL) 0.06 ± 0.02 0.05 ± 0.03 0.04 ± 0.02 0.06 ± 0.01 0.02 ± 0.01 0.2 ± 0.03 
Erythrocytes       
    Red blood cell (106/μL) 9.8 ± 0.3‡ 9.3 ± 0.3* 9.7 ± 0.1* 9.5 ± 0.3‡ 9.52 ± 0.55† 7.4 ± 0.3 
    Hemoglobin (g/dL) 13.5 ± 0.3‡ 13.2 ± 0.4† 13.7 ± 0.3* 15.1 ± 1.5‡ 15.5 ± 3.3‡ 9.4 ± 0.3 
    Hematocrit (%) 40.8 ± 0.9‡ 38.8 ± 1.5† 41.4 ± 0.7† 40.5 ± 1.2‡ 41.0 ± 2.4‡ 30 ± 0.8 
Thrombocytes       
    Platelet (103/μL) 974 ± 78 941 ± 62 825 ± 45 902 ± 72* 1026 ± 131 1389 ± 76 
    Mean platelet volume (fL) 4.6 ± 0.1 4.5 ± 0.07 4.5 ± 0.07 4.8 ± 0.1 4.3 ± 0.04† 5.0 ± 0.06 
GenotypesNo. of Flip alleles in whole genome
No. of Flip alleles in myeloid lineage
2 alleles (Flip+/+, f/+, or f/f)LysM+/+1 allele (Flipd/+or f/d) >LysM+/+2 alleles (Flip+/+) LysMc/+1 allele (Flipd/+ or f/+) LysMc/+1-2 alleles (Flip+/+, f/+, or +/d) LysMc/c0 alleles (Flipf/d) LysMc/+
Number 11 8 5 25 9 56 
Leukocytes       
    White blood cells (103/μL) 9.3 ± 1.1‡ 11.7 ± 1.3† 9.9 ± 2.2‡ 11.8 ± 1.2† 12.6 ± 2.3‡ 58.8 ± 5.9 
    Neutrophils (103/μL) 2.6 ± 0.60‡ 2.8 ± 0.78† 2.2 ± 0.50* 2.6 ± 0.36‡ 2.6 ± 0.58‡ 33.9 ± 4.1 
    Lymphocytes (103/μL) 6.1 ± 0.8 7.9 ± 0.9 7.1 ± 1.8 7.4 ± 0.80 9.0 ± 1.5 13.9 ± 1.7 
    Monocytes (103/μL) 0.5 ± 0.18‡ 0.8 ± 0.2† 0.5 ± 0.2 0.7 ± 0.1‡ 0.80 ± 0.15† 8.9 ± 1.2 
    Eosinophila (103/μL) 0.2 ± 0.04* 0.2 ± 0.07 0.1 ± 0.07 0.2 ± 0.04‡ 0.19 ± 0.09 1.9 ± 0.3 
    Basophila (103/μL) 0.06 ± 0.02 0.05 ± 0.03 0.04 ± 0.02 0.06 ± 0.01 0.02 ± 0.01 0.2 ± 0.03 
Erythrocytes       
    Red blood cell (106/μL) 9.8 ± 0.3‡ 9.3 ± 0.3* 9.7 ± 0.1* 9.5 ± 0.3‡ 9.52 ± 0.55† 7.4 ± 0.3 
    Hemoglobin (g/dL) 13.5 ± 0.3‡ 13.2 ± 0.4† 13.7 ± 0.3* 15.1 ± 1.5‡ 15.5 ± 3.3‡ 9.4 ± 0.3 
    Hematocrit (%) 40.8 ± 0.9‡ 38.8 ± 1.5† 41.4 ± 0.7† 40.5 ± 1.2‡ 41.0 ± 2.4‡ 30 ± 0.8 
Thrombocytes       
    Platelet (103/μL) 974 ± 78 941 ± 62 825 ± 45 902 ± 72* 1026 ± 131 1389 ± 76 
    Mean platelet volume (fL) 4.6 ± 0.1 4.5 ± 0.07 4.5 ± 0.07 4.8 ± 0.1 4.3 ± 0.04† 5.0 ± 0.06 
*

No difference among groups with 1 or 2 Flip alleles either in whole genome or in myeloid linage was identified. Significant differences were noted between the identified values compared with the Flip f/d, LyzM c/+ group, indicated by *P < .05,

†

P < .01, and

‡

P < .001.

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