Ten most discriminatory up- and down-regulated microRNAs differentially expressed (P < .05) between SzS (n = 21) and CD4+ controls (n = 6)
| Order . | microRNA . | P . | Fold change . | Chromosome . | Cluster . |
|---|---|---|---|---|---|
| +1 | miR-145 | 5.68 × 10−4 | 24.38 | 5q33.1 | 143-145 |
| +2 | miR-574–5p | 2.65 × 10−2 | 12.82 | 4p14 | — |
| +3 | miR-200c | 9.67 × 10−3 | 11.12 | 12p13.31 | 141-200c |
| +4 | miR-199a* | 2.60 × 10−2 | 8.58 | 19p13.2/1q24.3 | 199a-214 |
| +5 | miR-143 | 3.84 × 10−3 | 7.38 | 5q33.1 | 143-145 |
| +6 | miR-214 | 3.43 × 10−3 | 4.94 | 1q24.3 | 199a-214 |
| +7 | miR-98 | 2.48 × 10−3 | 4.91 | Xp11.22 | 98-let-7f |
| +8 | miR-518a-3p | 5.08 × 10−3 | 3.18 | 19q13.41 | — |
| +9 | miR-7 | 5.23 × 10−3 | 2.46 | 9q21.32/15q26.1/19p13.3 | — |
| +10 | miR-152 | 2.66 × 10−2 | 2.05 | 17q21.32 | — |
| −1 | miR-342 | 2.31 × 10−9 | −9.94 | 14q32.2 | — |
| −2 | miR-223 | 2.41 × 10−9 | −13.99 | Xq12 | — |
| −3 | miR-150 | 3.63 × 10−9 | −6.72 | 19q13.33 | — |
| −4 | miR-189(24*) | 2.82 × 10−8 | −3.97 | 9q22.32/19p13.12 | 24-23a/23b-24 |
| −5 | miR-186 | 5.04 × 10−8 | −6.4 | 1p31.1 | — |
| −6 | miR-423-3p | 5.04 × 10−8 | −2.24 | 17q11.2 | — |
| −7 | miR-92 | 5.22 × 10−8 | −5.6 | 13q31.3/Xq26.2 | 17-92/106a-363 |
| −8 | miR-181a | 5.22 × 10−8 | −4.4 | 1q32.1/9q33.3 | 181a-181b |
| −9 | miR-191 | 6.72 × 10−8 | −4.59 | 3p21.31 | 425-191 |
| −10 | miR-376a | 6.72 × 10−8 | −3.91 | 14q32.31 | — |
| Order . | microRNA . | P . | Fold change . | Chromosome . | Cluster . |
|---|---|---|---|---|---|
| +1 | miR-145 | 5.68 × 10−4 | 24.38 | 5q33.1 | 143-145 |
| +2 | miR-574–5p | 2.65 × 10−2 | 12.82 | 4p14 | — |
| +3 | miR-200c | 9.67 × 10−3 | 11.12 | 12p13.31 | 141-200c |
| +4 | miR-199a* | 2.60 × 10−2 | 8.58 | 19p13.2/1q24.3 | 199a-214 |
| +5 | miR-143 | 3.84 × 10−3 | 7.38 | 5q33.1 | 143-145 |
| +6 | miR-214 | 3.43 × 10−3 | 4.94 | 1q24.3 | 199a-214 |
| +7 | miR-98 | 2.48 × 10−3 | 4.91 | Xp11.22 | 98-let-7f |
| +8 | miR-518a-3p | 5.08 × 10−3 | 3.18 | 19q13.41 | — |
| +9 | miR-7 | 5.23 × 10−3 | 2.46 | 9q21.32/15q26.1/19p13.3 | — |
| +10 | miR-152 | 2.66 × 10−2 | 2.05 | 17q21.32 | — |
| −1 | miR-342 | 2.31 × 10−9 | −9.94 | 14q32.2 | — |
| −2 | miR-223 | 2.41 × 10−9 | −13.99 | Xq12 | — |
| −3 | miR-150 | 3.63 × 10−9 | −6.72 | 19q13.33 | — |
| −4 | miR-189(24*) | 2.82 × 10−8 | −3.97 | 9q22.32/19p13.12 | 24-23a/23b-24 |
| −5 | miR-186 | 5.04 × 10−8 | −6.4 | 1p31.1 | — |
| −6 | miR-423-3p | 5.04 × 10−8 | −2.24 | 17q11.2 | — |
| −7 | miR-92 | 5.22 × 10−8 | −5.6 | 13q31.3/Xq26.2 | 17-92/106a-363 |
| −8 | miR-181a | 5.22 × 10−8 | −4.4 | 1q32.1/9q33.3 | 181a-181b |
| −9 | miR-191 | 6.72 × 10−8 | −4.59 | 3p21.31 | 425-191 |
| −10 | miR-376a | 6.72 × 10−8 | −3.91 | 14q32.31 | — |
Positive fold changes are up-regulated in SzS samples and negative values down-regulated compared to controls. MicroRNAs also associated (P < .05) with B-cell lymphoma10 are indicated in bold.