SNP 6.0 array-based lesion detection (all lesions) and survival in AML (univariate analysis)
| SNP 6.0 array genomic lesions or other risk factors . | All-treatment group . | Intensive-treatment group . | ||||||
|---|---|---|---|---|---|---|---|---|
| Survival (median, d) . | Hazard ratio . | CI . | P . | Survival (median, d) . | Hazard ratio . | CI . | P . | |
| 0 vs ≥ 1 | 826/264 | 1.99 | 1.19-3.32 | < .008 | 870/338 | 1.94 | 1.11-3.39 | .02 |
| ≤ 1 vs ≥ 2 | 795/133 | 3.83 | 2.35-6.23 | < .001 | 870/134 | 3.58 | 2.1-6.12 | < .001 |
| ≤ 2 vs ≥ 3 | 584/122 | 3.77 | 2.31-6.16 | < .001 | 795/122 | 3.56 | 2.07-6.14 | < .001 |
| ≤ 9 vs ≥ 10 | 421/122 | 3.73 | 2.03-6.86 | < .001 | 472/109 | 3.76 | 1.83-7.75 | < .001 |
| 5q−/−5 vs not 5q−/−5 | 128/472 | 3.62 | 2.09-6.26 | < .001 | 128/584 | 3.46 | 1.85-6.48 | < .001 |
| 7q−/−7 vs not 7q−/−7 | 115/433 | 2.79 | 1.62-4.79 | < .001 | 102/530 | 3.07 | 1.68-5.62 | < .001 |
| p53 exons 2-9 mutations vs not | 104/433 | 4.16 | 2.33-7.41 | < .001 | 112/520 | 4.11 | 2.12-7.99 | < .001 |
| p53 exons 2-9 mutations or 17p-LOH vs not | 122/472 | 3.84 | 2.23-6.61 | < .001 | 123/568 | 3.46 | 1.85-6.49 | < .001 |
| SNP 6.0 array genomic lesions or other risk factors . | All-treatment group . | Intensive-treatment group . | ||||||
|---|---|---|---|---|---|---|---|---|
| Survival (median, d) . | Hazard ratio . | CI . | P . | Survival (median, d) . | Hazard ratio . | CI . | P . | |
| 0 vs ≥ 1 | 826/264 | 1.99 | 1.19-3.32 | < .008 | 870/338 | 1.94 | 1.11-3.39 | .02 |
| ≤ 1 vs ≥ 2 | 795/133 | 3.83 | 2.35-6.23 | < .001 | 870/134 | 3.58 | 2.1-6.12 | < .001 |
| ≤ 2 vs ≥ 3 | 584/122 | 3.77 | 2.31-6.16 | < .001 | 795/122 | 3.56 | 2.07-6.14 | < .001 |
| ≤ 9 vs ≥ 10 | 421/122 | 3.73 | 2.03-6.86 | < .001 | 472/109 | 3.76 | 1.83-7.75 | < .001 |
| 5q−/−5 vs not 5q−/−5 | 128/472 | 3.62 | 2.09-6.26 | < .001 | 128/584 | 3.46 | 1.85-6.48 | < .001 |
| 7q−/−7 vs not 7q−/−7 | 115/433 | 2.79 | 1.62-4.79 | < .001 | 102/530 | 3.07 | 1.68-5.62 | < .001 |
| p53 exons 2-9 mutations vs not | 104/433 | 4.16 | 2.33-7.41 | < .001 | 112/520 | 4.11 | 2.12-7.99 | < .001 |
| p53 exons 2-9 mutations or 17p-LOH vs not | 122/472 | 3.84 | 2.23-6.61 | < .001 | 123/568 | 3.46 | 1.85-6.49 | < .001 |