Grade 3 or 4 AEs (all cycles)
| Any grade 3 or 4 AE . | Total N = 21, in 26 patients . |
|---|---|
| Cohort 5 mg | |
| Thombosis | 1 |
| Eosinophilia | 1 |
| Cohort 10 mg | |
| Congestive heart failure | 2 |
| Neutropenia | 2 |
| Gastrointestinal hemorrhage | 1 |
| Atrial fibrillation | 1 |
| Cholangiocarcinoma | 1 |
| Urinary retention | 1 |
| Cohort 15 mg | |
| Cardiac ischemia | 1 |
| Congestive heart failure | 1 |
| Delirium | 1 |
| Hypoxia | 1 |
| Liver dysfunction | 1 |
| Cohort 20 mg | |
| Anemia | 1 |
| Neutropenia | 1 |
| Cerebrovascular ischemia | 1 |
| Muscle pain | 1 |
| Congestive heart failure | 1 |
| Renal failure | 1 |
| Any grade 3 or 4 AE . | Total N = 21, in 26 patients . |
|---|---|
| Cohort 5 mg | |
| Thombosis | 1 |
| Eosinophilia | 1 |
| Cohort 10 mg | |
| Congestive heart failure | 2 |
| Neutropenia | 2 |
| Gastrointestinal hemorrhage | 1 |
| Atrial fibrillation | 1 |
| Cholangiocarcinoma | 1 |
| Urinary retention | 1 |
| Cohort 15 mg | |
| Cardiac ischemia | 1 |
| Congestive heart failure | 1 |
| Delirium | 1 |
| Hypoxia | 1 |
| Liver dysfunction | 1 |
| Cohort 20 mg | |
| Anemia | 1 |
| Neutropenia | 1 |
| Cerebrovascular ischemia | 1 |
| Muscle pain | 1 |
| Congestive heart failure | 1 |
| Renal failure | 1 |