Table 4

Multivariate analysis of treatment failure (death or relapse) and death

VariableNRRLower CLUpper CLP
Treatment failure, main effect      
    Full intensity 1421 1.00    
    RIC 92 1.05 0.78 1.41 .75 
Treatment failure, other significant factors      
    Patient age at transplantation, y      
        Less than 30 820 1.00   Poverall < .001 
        30-39 327 1.32 1.12 1.56 .001 
        40-49 223 1.37 1.13 1.67 .002 
        50 or more 143 1.65 1.29 2.11 < .001 
    KPS before transplantation      
        Less than 80% 118 1.00   Poverall < .001 
        80% or more 1333 0.62 0.49 0.77 < .001 
        Missing 62 0.84 0.58 1.23 .37 
    TBI as part of conditioning regimen      
        Yes 1285 1.00    
        No 228 1.40 1.16 1.68 .001 
    Disease status before transplantation      
        CR1 795 1.00   Poverall < .001 
        CR2, CR1 duration < 12 mo 224 1.92 1.59 2.33 < .001 
        CR2, CR1 duration ≥ 12 mo 390 1.46 1.23 1.73 < .001 
        CR2, CR1 duration missing 104 1.42 1.09 1.84 .01 
    Type of donor      
        HLA-identical sibling 610 1.00   Poverall < .001 
        Unrelated well matched 428 1.07 0.89 1.28 .50 
        Unrelated partially matched 314 1.24 1.03 1.50 .02 
        Unrelated mismatched/unknown 161 1.96 1.58 2.43 < .001 
    Year of transplantation      
        2002-2007 783 1.00    
        1995-2001 730 1.26 1.08 1.46 .003 
Death, main effect      
    Full intensity 1421 1.00    
    RIC 92 0.92 0.69 1.24 .60 
Death, other significant factors      
    Patient age at transplantation, y      
        Less than 30 820 1.00   Poverall < .001 
        30-39 327 1.38 1.16 1.63 < .001 
        40-49 223 1.49 1.22 1.81 < .001 
        50 or more 143 1.88 1.46 2.42 < .001 
    KPS before transplantation      
        Less than 80% 119 1.00   Poverall < .001 
        80% or more 1339 0.62 0.49 0.78 < .001 
        Missing 63 0.82 0.56 1.20 .31 
    WBC at diagnosis, ×109/L      
        Less than 25 764 1.00   Poverall = .003 
        25-100 301 1.25 1.04 1.49 .017 
        More than 100 224 1.40 1.15 1.71 .001 
        Missing 224 1.17 0.96 1.42 .12 
    TBI as part of conditioning regimen      
        Yes 1285 1.00    
        No 228 1.44 1.20 1.73 < .001 
    Disease status before transplantation      
        CR1 795 1.00    
        CR2 718 1.69 1.46 1.96 < .001 
    Type of donor      
        HLA-identical sibling 610 1.00   Poverall < .001 
        Unrelated well matched 428 1.11 0.92 1.34 .26 
        Unrelated partially matched 314 1.34 1.12 1.61 .002 
        Unrelated mismatched/unknown 161 2.13 1.72 2.63 < .001 
    Year of transplantation      
        2002-2007 783 1.00    
        1995-2001 730 1.26 1.08 1.47 .003 
VariableNRRLower CLUpper CLP
Treatment failure, main effect      
    Full intensity 1421 1.00    
    RIC 92 1.05 0.78 1.41 .75 
Treatment failure, other significant factors      
    Patient age at transplantation, y      
        Less than 30 820 1.00   Poverall < .001 
        30-39 327 1.32 1.12 1.56 .001 
        40-49 223 1.37 1.13 1.67 .002 
        50 or more 143 1.65 1.29 2.11 < .001 
    KPS before transplantation      
        Less than 80% 118 1.00   Poverall < .001 
        80% or more 1333 0.62 0.49 0.77 < .001 
        Missing 62 0.84 0.58 1.23 .37 
    TBI as part of conditioning regimen      
        Yes 1285 1.00    
        No 228 1.40 1.16 1.68 .001 
    Disease status before transplantation      
        CR1 795 1.00   Poverall < .001 
        CR2, CR1 duration < 12 mo 224 1.92 1.59 2.33 < .001 
        CR2, CR1 duration ≥ 12 mo 390 1.46 1.23 1.73 < .001 
        CR2, CR1 duration missing 104 1.42 1.09 1.84 .01 
    Type of donor      
        HLA-identical sibling 610 1.00   Poverall < .001 
        Unrelated well matched 428 1.07 0.89 1.28 .50 
        Unrelated partially matched 314 1.24 1.03 1.50 .02 
        Unrelated mismatched/unknown 161 1.96 1.58 2.43 < .001 
    Year of transplantation      
        2002-2007 783 1.00    
        1995-2001 730 1.26 1.08 1.46 .003 
Death, main effect      
    Full intensity 1421 1.00    
    RIC 92 0.92 0.69 1.24 .60 
Death, other significant factors      
    Patient age at transplantation, y      
        Less than 30 820 1.00   Poverall < .001 
        30-39 327 1.38 1.16 1.63 < .001 
        40-49 223 1.49 1.22 1.81 < .001 
        50 or more 143 1.88 1.46 2.42 < .001 
    KPS before transplantation      
        Less than 80% 119 1.00   Poverall < .001 
        80% or more 1339 0.62 0.49 0.78 < .001 
        Missing 63 0.82 0.56 1.20 .31 
    WBC at diagnosis, ×109/L      
        Less than 25 764 1.00   Poverall = .003 
        25-100 301 1.25 1.04 1.49 .017 
        More than 100 224 1.40 1.15 1.71 .001 
        Missing 224 1.17 0.96 1.42 .12 
    TBI as part of conditioning regimen      
        Yes 1285 1.00    
        No 228 1.44 1.20 1.73 < .001 
    Disease status before transplantation      
        CR1 795 1.00    
        CR2 718 1.69 1.46 1.96 < .001 
    Type of donor      
        HLA-identical sibling 610 1.00   Poverall < .001 
        Unrelated well matched 428 1.11 0.92 1.34 .26 
        Unrelated partially matched 314 1.34 1.12 1.61 .002 
        Unrelated mismatched/unknown 161 2.13 1.72 2.63 < .001 
    Year of transplantation      
        2002-2007 783 1.00    
        1995-2001 730 1.26 1.08 1.47 .003 

CL indicates confidence limit.

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