Table 3 Multivariate analysis of TRM and... | American Society of Hematology

Table 3

Multivariate analysis of TRM and relapse

Variable	N	RR	Lower CL	Upper CL	P
TRM, main effect*
Full intensity	1428	1.00
RIC	93	0.98	0.66	1.46	.92
TRM, other significant factors
Patient age at transplantation, y
Less than 30	821	1.00			P_overall < .001
30-39	330	1.49	1.19	1.86	.001
40-49	226	1.52	1.17	1.96	.002
50 or more	144	1.89	1.36	2.63	< .001
KPS before transplantation
Less than 80%	119	1.00			P_overall = .014
80% or more	1339	0.65	0.48	0.87	.005
Missing	63	0.79	0.48	1.32	.37
Disease status before transplantation
CR1	802	1.00
CR2	719	1.35	1.11	1.63	.001
Type of donor
HLA-identical sibling	617	1.00			P_overall < .001
Unrelated well matched	428	1.11	0.86	1.44	.42
Unrelated partially matched	315	1.43	1.12	1.84	.005
Unrelated mismatched/unknown	161	2.47	1.88	3.25	< .001
Year of transplantation
2002-2007	784	1.00
1995-2001	737	1.39	1.12	1.72	.003
GVHD prophylaxis
Tacrolimus- or CSA-based ± MTX ± other	1340	1.00			P_overall = .012
TCD	126	1.45	1.09	1.90	.001
Other/none/missing	55	1.03	0.61	1.76	.91
Relapse, main effect
Full intensity	1428	1.00
RIC	93	1.35	0.91	2.01	.14
Relapse, other significant factors
KPS before transplantation
Less than 80%	119	1.00			.001
80% or more	1339	0.56	0.40	0.78	.001
Missing	63	0.83	0.48	1.43	.51
TBI given for conditioning regimen
Yes	1293	1.00
No	228	1.55	1.18	2.03	.002
Disease status before transplantation
CR1	802	1.00			P_overall < .001
CR2, CR1 duration < 12 mo	224	2.75	2.12	3.57	< .001
CR2, CR1 duration ≥ 12 mo	391	1.51	1.18	1.93	.001
CR2, CR1 duration missing	104	1.29	0.85	1.97	.23

Variable	N	RR	Lower CL	Upper CL	P
TRM, main effect*
Full intensity	1428	1.00
RIC	93	0.98	0.66	1.46	.92
TRM, other significant factors
Patient age at transplantation, y
Less than 30	821	1.00			P_overall < .001
30-39	330	1.49	1.19	1.86	.001
40-49	226	1.52	1.17	1.96	.002
50 or more	144	1.89	1.36	2.63	< .001
KPS before transplantation
Less than 80%	119	1.00			P_overall = .014
80% or more	1339	0.65	0.48	0.87	.005
Missing	63	0.79	0.48	1.32	.37
Disease status before transplantation
CR1	802	1.00
CR2	719	1.35	1.11	1.63	.001
Type of donor
HLA-identical sibling	617	1.00			P_overall < .001
Unrelated well matched	428	1.11	0.86	1.44	.42
Unrelated partially matched	315	1.43	1.12	1.84	.005
Unrelated mismatched/unknown	161	2.47	1.88	3.25	< .001
Year of transplantation
2002-2007	784	1.00
1995-2001	737	1.39	1.12	1.72	.003
GVHD prophylaxis
Tacrolimus- or CSA-based ± MTX ± other	1340	1.00			P_overall = .012
TCD	126	1.45	1.09	1.90	.001
Other/none/missing	55	1.03	0.61	1.76	.91
Relapse, main effect
Full intensity	1428	1.00
RIC	93	1.35	0.91	2.01	.14
Relapse, other significant factors
KPS before transplantation
Less than 80%	119	1.00			.001
80% or more	1339	0.56	0.40	0.78	.001
Missing	63	0.83	0.48	1.43	.51
TBI given for conditioning regimen
Yes	1293	1.00
No	228	1.55	1.18	2.03	.002
Disease status before transplantation
CR1	802	1.00			P_overall < .001
CR2, CR1 duration < 12 mo	224	2.75	2.12	3.57	< .001
CR2, CR1 duration ≥ 12 mo	391	1.51	1.18	1.93	.001
CR2, CR1 duration missing	104	1.29	0.85	1.97	.23

CL indicates confidence limit.

Stratified variable: graft type.