Table 1

GO enrichment analysis of the myeloid cell–specific gene set downstream of Spi1

TermCount%P
GO_biological process    
GO:0006817—phosphate transport 7 4.49 < .001 
    GO:0030097—hemopoiesis 8 5.13 < .001 
    GO:0006820—anion transport 8 5.13 .001 
    GO:0048513—organ development 22 14.10 .001 
    GO:0048534—hemopoietic or lymphoid organ development 8 5.13 .001 
    GO:0065008—regulation of biologic quality 17 10.90 .002 
    GO:0002520—immune system development 8 5.13 .002 
    GO:0015698—inorganic anion transport 7 4.49 .002 
    GO:0006915—apoptosis 15 9.62 .004 
    GO:0012501—programmed cell death 15 9.62 .005 
    GO:0030099—myeloid cell differentiation 5 3.21 .006 
    GO:0008219—cell death 15 9.62 .007 
    GO:0016265—death 15 9.62 .007 
    GO:0032502—developmental process 39 25.00 .009 
GO_cellular component    
    GO:0005737—cytoplasm 77 49.36 < .001 
    GO:0044424—intracellular part 100 64.10 < .001 
    GO:0005622—intracellular 104 66.67 < .001 
    GO:0005764—lysosome 9 5.77 < .001 
    GO:0000323—lytic vacuole 9 5.77 < .001 
    GO:0005829—cytosol 14 8.97 < .001 
    GO:0005773—vacuole 9 5.77 < .001 
    GO:0044445—cytosolic part 7 4.49 < .001 
    GO:0044420—extracellular matrix part 6 3.85 .002 
    GO:0044444—cytoplasmic part 44 28.21 .003 
GO_molecular function    
    GO:0005515—protein binding 73 46.79 < .001 
    GO:0005198—structural molecule activity 15 9.62 .007 
TermCount%P
GO_biological process    
GO:0006817—phosphate transport 7 4.49 < .001 
    GO:0030097—hemopoiesis 8 5.13 < .001 
    GO:0006820—anion transport 8 5.13 .001 
    GO:0048513—organ development 22 14.10 .001 
    GO:0048534—hemopoietic or lymphoid organ development 8 5.13 .001 
    GO:0065008—regulation of biologic quality 17 10.90 .002 
    GO:0002520—immune system development 8 5.13 .002 
    GO:0015698—inorganic anion transport 7 4.49 .002 
    GO:0006915—apoptosis 15 9.62 .004 
    GO:0012501—programmed cell death 15 9.62 .005 
    GO:0030099—myeloid cell differentiation 5 3.21 .006 
    GO:0008219—cell death 15 9.62 .007 
    GO:0016265—death 15 9.62 .007 
    GO:0032502—developmental process 39 25.00 .009 
GO_cellular component    
    GO:0005737—cytoplasm 77 49.36 < .001 
    GO:0044424—intracellular part 100 64.10 < .001 
    GO:0005622—intracellular 104 66.67 < .001 
    GO:0005764—lysosome 9 5.77 < .001 
    GO:0000323—lytic vacuole 9 5.77 < .001 
    GO:0005829—cytosol 14 8.97 < .001 
    GO:0005773—vacuole 9 5.77 < .001 
    GO:0044445—cytosolic part 7 4.49 < .001 
    GO:0044420—extracellular matrix part 6 3.85 .002 
    GO:0044444—cytoplasmic part 44 28.21 .003 
GO_molecular function    
    GO:0005515—protein binding 73 46.79 < .001 
    GO:0005198—structural molecule activity 15 9.62 .007 

The sets of significant ENTREZ Gene IDs were converted to human ENSEMBL gene IDs using g:orth function from G:profiler (http://biit.cs.ut.ee/gprofiler/) and subjected to GO enrichment analysis using the DAVID database (http://david.abcc.ncifcrf.gov/).33  The resulting categories were considered significant with P ≤ .001 and an E value of 1.32 or higher. The gene groups with fewer than 5 members were discarded.

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