Features of TCL1 leukemias treated with R788 in vivo
| Leukemia . | Model . | Sex . | VH gene . | D . | JH . | CDR3 . | Ag specificity . | phospho-SykY352 . | ZAP-70 . | CD38 . | Response to R788 therapy . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| (% hom) . | |||||||||||
| TCL1-002 | Adoptive transfer | Female recipients | V12S1 (100%) | Q52 | J1 | CAG-DRTGYWYFDV-W | Confirmed anti-PtC | Strong | neg. | pos. | Yes |
| TCL1-551 | Adoptive transfer | Female recipients | V7-3 (100%) | D1-1 | J4 | CAR-YYYGSSYAMDY-W | Unknown | Weak | neg. | pos. | Yes |
| TCL1-870 | Adoptive transfer | Female recipients | V1-55 (100%) | D1-1 | J1 | CAR-RYYGSSYWYFDV-W | Unknown | Weak | neg. | pos. | Yes |
| TCL1-137 | Spontaneous | Female | V1-55 (100%) | D1-1 | J1 | CAR-IYYGSSYWYFDV-W | Unknown | Weak | neg. | pos. | Yes |
| TCL1-045 | Spontaneous | Female | V11-2 (100%) | D2-3 | J1 | CMR-YDGYYWYFDV-W | VH sequence homology with anti-PtC Abs | Strong | neg. | pos. | Yes |
| TCL1-093 | Spontaneous | Male | V6-6 (100%) | D3-3 | J2 | CTT-SLRL-W | Unknown | Moderate | neg. | pos. | Yes |
| TCL1-103 | Spontaneous | Male | V1-80 (100%) | D2-11 | J2 | CAR-SWYYFDY-W | Unknown | Moderate | neg. | pos. | Yes |
| TCL1-121 | Spontaneous | Male | V1-52 (100%) | D2-1 | J1 | CAI-YYGNYWYFDV-W | Unknown | n.d. | n.d. | n.d. | Yes |
| TCL1-123 | Spontaneous | Female | V1-52 (99.6%) | D1-1 | J1 | CAS-YGSSYWYFDV-W | Unknown | n.d. | n.d. | n.d. | No |
| TCL1-104 | Spontaneous | Female | V11-2 (100%) | D2-1 | J1 | CMR-YGNYWYFDV-W | VH sequence homology with anti-PtC Abs | n.d. | n.d. | n.d. | No |
| TCL1-275 | Spontaneous | Male | V11-2 (100%) | D2-1 | J1 | CMR-YGNYWYFDV-W | VH sequence homology with anti-PtC Abs | Moderate | neg. | pos. | No |
| Leukemia . | Model . | Sex . | VH gene . | D . | JH . | CDR3 . | Ag specificity . | phospho-SykY352 . | ZAP-70 . | CD38 . | Response to R788 therapy . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| (% hom) . | |||||||||||
| TCL1-002 | Adoptive transfer | Female recipients | V12S1 (100%) | Q52 | J1 | CAG-DRTGYWYFDV-W | Confirmed anti-PtC | Strong | neg. | pos. | Yes |
| TCL1-551 | Adoptive transfer | Female recipients | V7-3 (100%) | D1-1 | J4 | CAR-YYYGSSYAMDY-W | Unknown | Weak | neg. | pos. | Yes |
| TCL1-870 | Adoptive transfer | Female recipients | V1-55 (100%) | D1-1 | J1 | CAR-RYYGSSYWYFDV-W | Unknown | Weak | neg. | pos. | Yes |
| TCL1-137 | Spontaneous | Female | V1-55 (100%) | D1-1 | J1 | CAR-IYYGSSYWYFDV-W | Unknown | Weak | neg. | pos. | Yes |
| TCL1-045 | Spontaneous | Female | V11-2 (100%) | D2-3 | J1 | CMR-YDGYYWYFDV-W | VH sequence homology with anti-PtC Abs | Strong | neg. | pos. | Yes |
| TCL1-093 | Spontaneous | Male | V6-6 (100%) | D3-3 | J2 | CTT-SLRL-W | Unknown | Moderate | neg. | pos. | Yes |
| TCL1-103 | Spontaneous | Male | V1-80 (100%) | D2-11 | J2 | CAR-SWYYFDY-W | Unknown | Moderate | neg. | pos. | Yes |
| TCL1-121 | Spontaneous | Male | V1-52 (100%) | D2-1 | J1 | CAI-YYGNYWYFDV-W | Unknown | n.d. | n.d. | n.d. | Yes |
| TCL1-123 | Spontaneous | Female | V1-52 (99.6%) | D1-1 | J1 | CAS-YGSSYWYFDV-W | Unknown | n.d. | n.d. | n.d. | No |
| TCL1-104 | Spontaneous | Female | V11-2 (100%) | D2-1 | J1 | CMR-YGNYWYFDV-W | VH sequence homology with anti-PtC Abs | n.d. | n.d. | n.d. | No |
| TCL1-275 | Spontaneous | Male | V11-2 (100%) | D2-1 | J1 | CMR-YGNYWYFDV-W | VH sequence homology with anti-PtC Abs | Moderate | neg. | pos. | No |
hom indicates homology; n.d., not determined; neg., negative; and pos., positive.