Table 1

Transplantation of Ptpn11D61G/+ whole BM cells or LSK cells, but not CMPs or GMPs reproduced MPD in recipient mice

No. of Ptpn11D61G/+ cellsNo. of competitor cellsNo. of carrier cellsIncidence of MPD
5 × 105 BM cells 5 × 105 BM cells  8/8 
4 × 104 BM cells 2 × 105 BM cells  2/5 
8 × 103 BM cells 2 × 105 BM cells  1/5 
1600 BM cells 2 × 105 BM cells  0/5 
300 BM cells 2 × 105 BM cells  0/5 
400 LSK cells 1000 LSK cells 1 × 104 Lin+ cells 3/5 
170 LSK cells 1300 LSK cells 1 × 104 Lin+ cells 0/5 
1000 LSK cells  1 × 105 BM cells 2/2 
4000 CMPs  1 × 105 BM cells 0/4 
4000 GMPs  1 × 105 BM cells 0/4 
No. of Ptpn11D61G/+ cellsNo. of competitor cellsNo. of carrier cellsIncidence of MPD
5 × 105 BM cells 5 × 105 BM cells  8/8 
4 × 104 BM cells 2 × 105 BM cells  2/5 
8 × 103 BM cells 2 × 105 BM cells  1/5 
1600 BM cells 2 × 105 BM cells  0/5 
300 BM cells 2 × 105 BM cells  0/5 
400 LSK cells 1000 LSK cells 1 × 104 Lin+ cells 3/5 
170 LSK cells 1300 LSK cells 1 × 104 Lin+ cells 0/5 
1000 LSK cells  1 × 105 BM cells 2/2 
4000 CMPs  1 × 105 BM cells 0/4 
4000 GMPs  1 × 105 BM cells 0/4 
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