Minimally lost or gained regions less than 5 Mb in 3 or more cases (data based on the National Center for Biotechnology Information Built 36.1 human assembly), sorted by relative frequency
| Chromsome . | Cytoband . | Length (< 5 Mb) . | Relative frequency . | Potential target genes . |
|---|---|---|---|---|
| Losses | ||||
| 13 | 13q14.3-21.1 | 4797519 | 0.25 | LECT1 |
| 6 | 6q23.2 | 683447 | 0.23 | CTGF |
| 11 | 11q22.3 | 2826040 | 0.23 | ATM |
| 7 | 7q34-35 | 3510852 | 0.17 | ZYX |
| 1 | 1p36.31-33 | 4408633 | 0.13 | TNFRSF14,* PRKCZ,* TP73 |
| 14 | 14q32.31-32.33 | 4714542 | 0.08 | HSP90, TNFAIP2 |
| Gains | ||||
| 9 | 9p24.1-24.3 | 4749650 | 0.40 | JAK2 |
| 9 | 9p21.1 | 757283 | 0.38 | ACO1 |
| 2 | 2p15-16.1 | 4804518 | 0.28 | REL* |
| 17 | 17q21.31-32 | 3894954 | 0.25 | HOXB1-B9, TBX21, MAP3K14,* ITGB3* |
| 20 | 20q13.11-13.12 | 3489871 | 0.21 | CD40* |
| 20 | 20q13.2 | 1442350 | 0.21 | TSHZ2, ZNF217 |
| 5 | 5p13.2 | 2597057 | 0.11 | IL7R |
| 8 | 8q24.21 | 1389530 | 0.09 | MYC |
| 12 | 12q24.31-24.32 | 1789670 | 0.09 | UBC |
| 14 | 14q22.1-22.2 | 3377578 | 0.09 | PTGDR, BMP4* |
| 1 | 1q32.1 | 3976681 | 0.08 | PTPN7 |
| 8 | 8p11.21 | 599180 | 0.08 | IKBKB (IKK-2)* |
| 1 | 1q23.2-23.3 | 1877267 | 0.06 | CD48 (SLAMF1), SLAMF2 |
| 5 | 5q31.2-31.3 | 4339424 | 0.06 | CD14, ETF1, WNT8A |
| Chromsome . | Cytoband . | Length (< 5 Mb) . | Relative frequency . | Potential target genes . |
|---|---|---|---|---|
| Losses | ||||
| 13 | 13q14.3-21.1 | 4797519 | 0.25 | LECT1 |
| 6 | 6q23.2 | 683447 | 0.23 | CTGF |
| 11 | 11q22.3 | 2826040 | 0.23 | ATM |
| 7 | 7q34-35 | 3510852 | 0.17 | ZYX |
| 1 | 1p36.31-33 | 4408633 | 0.13 | TNFRSF14,* PRKCZ,* TP73 |
| 14 | 14q32.31-32.33 | 4714542 | 0.08 | HSP90, TNFAIP2 |
| Gains | ||||
| 9 | 9p24.1-24.3 | 4749650 | 0.40 | JAK2 |
| 9 | 9p21.1 | 757283 | 0.38 | ACO1 |
| 2 | 2p15-16.1 | 4804518 | 0.28 | REL* |
| 17 | 17q21.31-32 | 3894954 | 0.25 | HOXB1-B9, TBX21, MAP3K14,* ITGB3* |
| 20 | 20q13.11-13.12 | 3489871 | 0.21 | CD40* |
| 20 | 20q13.2 | 1442350 | 0.21 | TSHZ2, ZNF217 |
| 5 | 5p13.2 | 2597057 | 0.11 | IL7R |
| 8 | 8q24.21 | 1389530 | 0.09 | MYC |
| 12 | 12q24.31-24.32 | 1789670 | 0.09 | UBC |
| 14 | 14q22.1-22.2 | 3377578 | 0.09 | PTGDR, BMP4* |
| 1 | 1q32.1 | 3976681 | 0.08 | PTPN7 |
| 8 | 8p11.21 | 599180 | 0.08 | IKBKB (IKK-2)* |
| 1 | 1q23.2-23.3 | 1877267 | 0.06 | CD48 (SLAMF1), SLAMF2 |
| 5 | 5q31.2-31.3 | 4339424 | 0.06 | CD14, ETF1, WNT8A |
A selection of genes with biological plausibility is shown. Genomic coordinates for each region are given in the supplemental Methods.
Nuclear factor κB signaling pathway genes by ingenuity analysis.