Cytogenetic entities predicting significantly poorer overall survival in multivariable analysis
| Factor . | HR . | 99% CI . | P to enter model . |
|---|---|---|---|
| Individual abnormalities | |||
| Age, per year | 1.018 | 1.013-1.023 | |
| WBC, per unit increase | 1.003 | 1.002-1.003 | |
| Secondary disease | 1.54 | 1.31-1.82 | |
| Performance status | 1.15 | 1.09-1.21 | |
| −5 | 1.82 | 1.34-2.48 | < .001 |
| del(5q)/add(5q) | 1.73 | 1.37-2.19 | < .001 |
| inv(3) | 2.52 | 1.76-3.62 | < .001 |
| abn(3q) | 1.85 | 1.38-2.48 | < .001 |
| −7 | 1.51 | 1.22-1.88 | < .001 |
| t(10;11) | 2.62 | 1.59-4.29 | < .001 |
| +8 | 1.33 | 1.12-1.57 | < .001 |
| abn(17p) | 1.63 | 1.21-2.20 | < .001 |
| −17 | 1.58 | 1.15-2.17 | < .001 |
| t(6;11) | 2.25 | 1.26-4.03 | < .001 |
| add(7q)/del(7q) | 1.34 | 1.05-1.72 | .003 |
| t(11q23)* | 1.55 | 1.06-2.28 | .003 |
| t(9;22) | 1.64 | 1.04-2.56 | .004 |
| Additional effect of complexity in above model | |||
| > 3 abnormalities | 1.58 | 1.29-1.93 | < .001 |
| Factor . | HR . | 99% CI . | P to enter model . |
|---|---|---|---|
| Individual abnormalities | |||
| Age, per year | 1.018 | 1.013-1.023 | |
| WBC, per unit increase | 1.003 | 1.002-1.003 | |
| Secondary disease | 1.54 | 1.31-1.82 | |
| Performance status | 1.15 | 1.09-1.21 | |
| −5 | 1.82 | 1.34-2.48 | < .001 |
| del(5q)/add(5q) | 1.73 | 1.37-2.19 | < .001 |
| inv(3) | 2.52 | 1.76-3.62 | < .001 |
| abn(3q) | 1.85 | 1.38-2.48 | < .001 |
| −7 | 1.51 | 1.22-1.88 | < .001 |
| t(10;11) | 2.62 | 1.59-4.29 | < .001 |
| +8 | 1.33 | 1.12-1.57 | < .001 |
| abn(17p) | 1.63 | 1.21-2.20 | < .001 |
| −17 | 1.58 | 1.15-2.17 | < .001 |
| t(6;11) | 2.25 | 1.26-4.03 | < .001 |
| add(7q)/del(7q) | 1.34 | 1.05-1.72 | .003 |
| t(11q23)* | 1.55 | 1.06-2.28 | .003 |
| t(9;22) | 1.64 | 1.04-2.56 | .004 |
| Additional effect of complexity in above model | |||
| > 3 abnormalities | 1.58 | 1.29-1.93 | < .001 |
CI indicates confidence interval; HR, hazard ratio; and WBC, white blood cell.
Excluding t(9;11)(p21∼22;q23) and t(11;19)(q23;p13).