Impact of cytogenetic abnormalities compared with normal karyotype on disease outcome
| Chromosome involved . | Description of abnormality . | CR* . | OS . | CIR . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Rate, % . | Unadjusted OR (99% CI), P† . | Adjusted OR (99% CI), P† . | 10-y OS, % . | Unadjusted HR (99% CI), P‡ . | Adjusted HR (99% CI), P§ . | 10-y CIR . | Unadjusted HR (99% CI), P‡ . | Adjusted HR (99% CI), P§ . | ||
| — | Normal karyotype | 90 | 38 | 49 | ||||||
| 1 | Abnormality of 1p | 68 | 4.13 (2.21-7.71), < .001 | 5.51 (2.81-10.80), < .001 | 20 | 2.58 (1.64-4.05), < .001 | 2.20 (1.57-3.08), < .001 | 58 | 1.64 (0.93-2.91), .03 | 1.62 (1.01-2.60), .008 |
| Abnormality of 1q | 63 | 5.19 (2.82-9.55), < .001 | 5.78 (3.02-11.07), < .001 | 21 | 2.26 (1.45-3.54), < .001 | 1.88 (1.33-2.65), < .001 | 55 | 1.26 (0.72-2.19), .3 | 1.30 (0.78-2.15), .19 | |
| 3 | Monosomy 3 | 46 | 10.16 (4.36-23.65), < .001 | 12.11 (5.02-29.19), < .001 | 3 | 24.46 (10.01-59.76), < .001 | 4.20 (2.68-6.58), < .001 | 82 | 75.92 (17.15-336.0), < .001 | 5.17 (2.68-9.96), < .001 |
| Abnormality of 3q | ||||||||||
| inv(3)(q21q26)/t(3;3)(q21;q26) | 36 | 15.33 (7.86-29.88), < .001 | 19.80 (9.79-40.07), < .001 | 3 | 13.22 (7.14-24.48), < .001 | 4.07 (2.89-5.72), < .001 | 89 | 14.41 (4.64-44.74), < .001 | 4.04 (2.22-7.36), < .001 | |
| t(3;5)(q21∼25;q31∼35) | 96 | 0.36 (0.03-5.06), .3 | 0.44 (0.03-6.51), .4 | 34 | 1.38 (0.66-2.90), .3 | 1.41 (0.72-2.77), .18 | 52 | 1.46 (0.61-3.50), .3 | 1.53 (0.72-3.25), .14 | |
| Other abnormality of 3q | 59 | 6.08 (3.56-10.38), < .001 | 6.98 (3.97-12.25), < .001 | 11.3 | 5.20 (3.32-8.14), < .001 | 2.77 (2.08-3.68), < .001 | 71 | 5.21 (2.70-10.05), < .001 | 2.71 (1.79-4.09), < .001 | |
| 4 | Trisomy 4 | 87 | 1.31 (0.51-3.33), .5 | 1.55 (0.57-4.24), .3 | 16 | 1.15 (0.74-1.80), .4 | 1.23 (0.80-1.88), .2 | 54 | 1.09 (0.64-1.83), .7 | 1.13 (0.68-1.87), .5 |
| 5 | Abnormality of 5q | |||||||||
| Monosomy 5 | 57 | 6.56 (4.02-10.72), < .001 | 7.58 (4.49-12.80), < .001 | 0 | 20.31 (12.70-32.47), < .001 | 4.33 (3.35-5.61), < .001 | 75 | 16.98 (8.42-34.23), < .001 | 3.80 (2.59-5.57), < .001 | |
| del(5q) | 58 | 6.22 (3.90-9.93), < .001 | 7.28 (4.40-12.06), < .001 | 12 | 5.14 (3.47-7.62), < .001 | 2.90 (2.23-3.76), < .001 | 64 | 3.02 (1.75-5.19), < .001 | 2.19 (1.47-3.27), < .001 | |
| add(5q) | 53 | 7.62 (3.83-15.17), < .001 | 10.38 (4.96-21.72), < .001 | 10 | 10.49 (5.34-20.60), < .001 | 3.58 (2.42-5.30), < .001 | 64 | 6.05 (2.25-16.28), < .001 | 2.84 (1.53-5.26), < .001 | |
| 6 | Trisomy 6 | 78 | 2.44 (1.10-5.41), .004 | 2.52 (1.11-5.73), .003 | 21 | 2.34 (1.40-3.92), < .001 | 1.88 (1.28-2.76), < .001 | 62 | 2.12 (1.12-4.01), .005 | 1.75 (1.08-2.85), .003 |
| t(6;9)(p23;q34) | 88 | 1.18 (0.34-4.06), .7 | 1.65 (0.47-5.82), .3 | 27 | 1.47 (0.77-2.81), .14 | 1.55 (0.88-2.74), .04 | 62 | 1.70 (0.76-3.79), .10 | 1.61 (0.82-3.16), .06 | |
| Abnormality of 6q, not t(6;11) | 63 | 5.05 (2.70-9.44), < .001 | 6.15 (3.16-11.96), < .001 | 21 | 2.52 (1.58-4.02), < .001 | 2.09 (1.47-2.96), < .001 | 53 | 1.32 (0.73-2.38), .2 | 1.33 (0.78-2.26), .17 | |
| 7 | Monosomy 7 | 58 | 6.37 (4.46-9.11), < .001 | 7.63 (5.18-11.24), < .001 | 8 | 5.57 (4.20-7.38), < .001 | 3.03 (2.50-3.67), < .001 | 70 | 4.38 (2.92-6.55), < .001 | 2.60 (1.98-3.42), < .001 |
| Abnormality of 7q | ||||||||||
| del(7q) | 77 | 2.64 (1.54-4.52), < .001 | 2.76 (1.56-4.89), < .001 | 26 | 1.66 (1.20-2.31), < .001 | 1.51 (1.14-1.98), < .001 | 57 | 1.32 (0.88-1.98), .08 | 1.26 (0.87-1.81), .11 | |
| add(7q) | 68 | 4.17 (2.09-8.30), < .001 | 5.08 (2.43-10.61), < .001 | 30 | 2.25 (1.34-3.79), < .001 | 1.97 (1.33-2.94), < .001 | 33 | 0.96 (0.50-1.85), .9 | 1.01 (0.52-1.98), 1.0 | |
| Abnormality of 7p | 65 | 4.69 (2.50-8.79), < .001 | 6.06 (3.09-11.92), < .001 | 22 | 2.18 (1.39-3.43), < .001 | 1.97 (1.39-2.80), < .001 | 61 | 1.30 (0.75-2.25), .2 | 1.31 (0.79-2.17), .17 | |
| 8 | Trisomy 8 | 80 | 2.20 (1.58-3.07), < .001 | 2.64 (1.85-3.77), < .001 | 37 | 1.21 (1.01-1.44), .006 | 1.32 (1.12-1.57), < .001 | 46 | 0.99 (0.80-1.23), .9 | 1.08 (0.87-1.35), .3 |
| t(8;21)(q22;q22) and variants | 97 | 0.26 (0.12-0.56), < .001 | 0.36 (0.16-0.81), < .001 | 61 | .58 (0.49-0.70), < .001 | 0.60 (0.47-0.75), < .001 | 27 | 0.54 (0.44-0.67), < .001 | 0.51 (0.39-0.68), < .001 | |
| Abnormality of 8p11∼12 | 91 | 0.83 (0.12-5.62), 0.8 | 1.32 (0.19-9.26), .7 | 50 | 0.91 (0.43-1.92), .8 | 1.22 (0.56-2.68), .5 | 49 | 1.08 (0.46-2.53), .8 | 1.31 (0.57-2.98), .4 | |
| 9 | Monosomy 9 | 68 | 4.10 (1.34-12.53), .001 | 5.01 (1.57-15.99), < .001 | 8 | 4.04 (1.69-9.67), < .001 | 2.55 (1.42-4.57), < .001 | 63 | 3.00 (0.92-9.78), .03 | 2.13 (0.89-5.06), .02 |
| t(9;22)(q34;q11) and variants | 72 | 3.43 (1.45-8.12), < .001 | 2.80 (1.08-7.27), .004 | 14 | 2.83 (1.53-5.23), < .001 | 1.91 (1.22-3.00), < .001 | 65 | 3.95 (1.59-9.83), < .001 | 2.32 (1.27-4.23), < .001 | |
| Deletion of 9q, including add(9q) | 86 | 1.39 (0.71-2.73), .2 | 1.82 (0.90-3.68), .03 | 47 | 0.80 (0.58-1.09), .05 | 0.83 (0.58-1.19), .19 | 35 | 0.66 (0.46-0.94), .001 | 0.60 (0.38-0.96), .005 | |
| 11 | Trisomy 11 | 75 | 2.86 (1.44-5.67), < .001 | 3.25 (1.57-6.71), < .001 | 13 | 2.26 (1.44-3.55), < .001 | 1.84 (1.30-2.61), < .001 | 71 | 2.71 (1.52-4.84), < .001 | 2.01 (1.31-3.08), < .001 |
| All 11q23 | ||||||||||
| t(9;11)(p21∼22;q23) | 84 | 1.71 (0.69-4.23), .13 | 2.13 (0.82-5.51), .03 | 39 | 1.24 (0.75-2.04), .3 | 1.36 (0.86-2.17), .08 | 44 | 1.00 (0.56-1.79), 1.0 | 1.04 (0.57-1.89), .9 | |
| t(10;11)(p11∼14;q13∼23) | 85 | 1.50 (0.43-5.29), .4 | 2.58 (0.70-9.53), .05 | 12 | 3.57 (1.71-7.45), < .001 | 3.29 (1.99-5.45), < .001 | 71 | 4.94 (1.95-12.55), < .001 | 3.39 (1.87-6.15), < .001 | |
| t(6;11)(q27;q23) | 96 | 0.40 (0.03-5.54), .4 | 0.63 (0.04-9.04), .6 | 9 | 2.80 (1.23-6.38), .004 | 2.56 (1.42-4.61), < .001 | 76 | 5.10 (1.79-14.52), < .001 | 2.97 (1.53-5.74), < .001 | |
| t(11;19)(q23;p13) | 97 | 0.30 (0.02-4.15), .2 | 0.45 (0.03-6.36), .4 | 49 | 0.89 (0.46-1.71), .7 | 1.11 (0.55-2.22), .7 | 44 | 1.03 (0.48-2.19), .9 | 1.21 (0.57-2.56), .5 | |
| Other 11q23 | 75 | 3.03 (1.41-6.53), < .001 | 3.87 (1.70-8.82), < .001 | 21 | 2.55 (1.52-4.27), < .001 | 2.07 (1.41-3.04), < .001 | 65 | 2.40 (1.26-4.59), .002 | 1.84 (1.12-3.03), .001 | |
| Abnormality of 11q (not 11q23) | 69 | 3.92 (2.27-6.76), < .001 | 4.86 (2.72-8.68), < .001 | 20 | 2.33 (1.59-3.42), < .001 | 2.13 (1.59-2.86), < .001 | 62 | 2.02 (1.23-3.32), < .001 | 1.90 (1.28-2.82), < .001 | |
| Abnormality of 11p13∼15 | 73 | 3.23 (1.23-8.50), .002 | 4.58 (1.66-12.64), < .001 | 26 | 1.61 (0.86-3.01), .06 | 1.48 (0.87-2.52), .06 | 53 | 1.08 (0.51-2.27), .8 | 1.02 (0.48-2.15), 1.0 | |
| 12 | Abnormality of 12p | |||||||||
| Monosomy 12 | 59 | 6.07 (2.95-12.48), < .001 | 6.54 (3.05-14.00), < .001 | 6 | 11.79 (5.98-23.28), < .001 | 3.67 (2.51-5.37), < .001 | 84 | 21.17 (7.65-58.60), < .001 | 4.48 (2.65-7.58), < .001 | |
| Other abnormality of 12p13 | 63 | 5.06 (2.31-11.06), < .001 | 6.00 (2.62-13.73), < .001 | 14 | 4.18 (2.21-7.90), < .001 | 2.58 (1.69-3.92), < .001 | 48 | 1.44 (0.64-3.22), .3 | 1.31 (0.64-2.69), .3 | |
| Other abnormality of 12p, not 12p13 | 57 | 6.57 (3.73-11.58), < .001 | 8.45 (4.57-15.62), < .001 | 17 | 4.12 (2.56-6.65), < .001 | 2.75 (1.98-3.82), < .001 | 53 | 1.78 (0.94-3.37), .03 | 1.61 (0.93-2.80), .02 | |
| 13 | Trisomy 13 | 70 | 3.75 (2.05-6.89), < .001 | 3.62 (1.90-6.90), < .001 | 9 | 2.54 (1.64-3.93), < .001 | 1.86 (1.34-2.57), < .001 | 72 | 1.82 (1.05-3.14), .009 | 1.56 (1.00-2.42), .008 |
| Abnormality of 13q | ||||||||||
| Monosomy 13 | 60 | 5.87 (3.09-11.16), < .001 | 7.07 (3.57-14.02), < .001 | 8 | 9.02 (5.06-16.07), < .001 | 3.48 (2.48-4.88), < .001 | 67 | 5.88 (2.65-13.06), < .001 | 2.90 (1.76-4.75), < .001 | |
| Deletion of 13q | 85 | 1.51 (0.37-6.18), .4 | 2.10 (0.49-9.02), .18 | 31 | 1.25 (0.64-2.46), .4 | 1.46 (0.78-2.75), .12 | 61 | 1.45 (0.65-3.26), .2 | 1.61 (0.80-3.24), .07 | |
| 15 | t(15;17)(q22;q21) and variants | 93 | 0.67 (0.43-1.04), .02 | 1.11 (0.69-1.76), .6 | 81 | 0.40 (0.34-0.47), < .001 | 0.30 (0.23-0.39), < .001 | 13 | 0.34 (0.29-0.41), < .001 | 0.19 (0.13-0.27), < .001 |
| Abnormality of 15q, not t(15;17) | 78 | 2.53 (0.94-6.81), .02 | 3.36 (1.15-9.83), .002 | 46 | 0.96 (0.53-1.72), .9 | 1.10 (0.60-2.03), .7 | 45 | 0.91 (0.44-1.85), .8 | 1.07 (0.50-2.25), .8 | |
| 16 | inv(16)(p13q22)/t(16;16)(p13;q22) | 92 | 0.81 (0.46-1.44), .3 | 0.88 (0.48-1.62), .6 | 55 | 0.66 (0.53-0.82), < .001 | 0.64 (0.49-0.84), < .001 | 46 | 0.86 (0.67-1.10), .10 | 0.85 (0.65-1.12), .12 |
| Abnormality of 16q, not inv(16) | 78 | 2.45 (1.25-4.82), < .001 | 2.85 (1.41-5.79), < .001 | 31 | 1.66 (1.10-2.51), .003 | 1.60 (1.13-2.26), < .001 | 58 | 1.44 (0.87-2.40), .07 | 1.36 (0.87-2.13), .08 | |
| 17 | Monosomy 17 | 56 | 6.76 (4.07-11.21), < .001 | 8.20 (4.78-14.09), < .001 | 3 | 15.22 (9.37-24.72), < .001 | 3.96 (3.02-5.19), < .001 | 80 | 13.68 (6.68-28.01), < .001 | 3.62 (2.43-5.41), < .001 |
| Abnormality of 17p | 68 | 4.08 (2.47-6.73), < .001 | 4.91 (2.86-8.41), < .001 | 25 | 2.50 (1.75-3.59), < .001 | 2.11 (1.60-2.78), < .001 | 56 | 1.84 (1.16-2.92), .002 | 1.75 (1.20-2.56), < .001 | |
| 18 | Monosomy 18 | 61 | 5.46 (3.10-9.63), < .001 | 6.04 (3.29-11.06), < .001 | 4 | 12.40 (7.28-21.11), < .001 | 3.57 (2.64-4.84), < .001 | 78 | 15.76 (7.21-34.42), < .001 | 3.61 (2.35-5.56), < .001 |
| 19 | Trisomy 19 | 81 | 2.04 (0.85-4.91), .04 | 2.28 (0.91-5.70), .02 | 12 | 3.11 (1.81-5.34), < .001 | 2.35 (1.61-3.42), < .001 | 74 | 3.97 (2.00-7.86), < .001 | 2.54 (1.62-3.99), < .001 |
| 20 | Monosomy 20 | 67 | 4.35 (1.99-9.54), < .001 | 4.96 (2.19-11.21), < .001 | 6 | 6.65 (3.43-12.89), < .001 | 2.98 (1.99-4.45), < .001 | 88 | 8.77 (3.68-20.89), < .001 | 3.10 (1.88-5.14), < .001 |
| Abnormality of 20q | 66 | 4.49 (2.00-10.12), < .001 | 4.93 (2.05-11.86), < .001 | 16 | 3.59 (1.86-6.94), < .001 | 2.59 (1.65-4.06), < .001 | 71 | 3.81 (1.54-9.42), .001 | 2.62 (1.44-4.77), < .001 | |
| 21 | Trisomy 21 (acquired) | 74 | 3.01 (1.79-5.07), < .001 | 3.36 (1.92-5.88), < .001 | 21 | 1.88 (1.35-2.62), < .001 | 1.69 (1.28-2.21), < .001 | 66 | 1.94 (1.28-2.96), < .001 | 1.69 (1.20-2.37), < .001 |
| Abnormality of 21q, not t(8;21) | 71 | 3.59 (1.80-7.15), < .001 | 4.10 (1.98-8.50), < .001 | 17 | 2.37 (1.44-3.88), < .001 | 1.93 (1.34-2.80), < .001 | 61 | 1.89 (0.99-3.57), .02 | 1.66 (1.00-2.75), .009 | |
| 22 | Trisomy 22 | 84 | 1.67 (0.84-3.31), .05 | 2.04 (1.00-4.14), .009 | 47 | 0.85 (0.61-1.19), .2 | 0.90 (0.63-1.30), .5 | 42 | 0.81 (0.55-1.20), .16 | 0.81 (0.52-1.26), .2 |
| X | Loss of X | 87 | 1.28 (0.60-2.74), .4 | 1.89 (0.86-4.15), .03 | 56 | 0.70 (0.51-0.97), .003 | 0.75 (0.50-1.12), .06 | 23 | 0.54 (0.37-0.78), < .001 | 0.44 (0.24-0.79), < .001 |
| Y | Loss of Y | 89 | 1.08 (0.59-1.99), .7 | 1.47 (0.79-2.74), .11 | 51 | 0.75 (0.58-0.96), .002 | 0.79 (0.59-1.06), .04 | 33 | 0.65 (0.48-0.86), < .001 | 0.62 (0.42-0.90), < .001 |
| Level of karyotype complexity | ||||||||||
| 1 abnormality | 87 | per abnormality: OR 1.37 (1.30-1.46), < .001 | per abnormality: OR 1.42 (1.33-1.51), < .001 | 47 | per abnormality HR 1.17 (1.13-1.20), < .001 | per abnormality: HR 1.19 (1.15-1.22), < .001 | 42 | per abnormality: HR 1.09 (1.04-1.13), < .001 | per abnormality HR 1.11 (1.06-1.16), < .001 | |
| 2 abnormalities | 85 | 45 | 40 | |||||||
| 3 abnormalities | 83 | 48 | 35 | |||||||
| 4 abnormalities | 74 | 30 | 51 | |||||||
| 5 or more abnormalities | 62 | 10 | 69 | |||||||
| Chromosome involved . | Description of abnormality . | CR* . | OS . | CIR . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Rate, % . | Unadjusted OR (99% CI), P† . | Adjusted OR (99% CI), P† . | 10-y OS, % . | Unadjusted HR (99% CI), P‡ . | Adjusted HR (99% CI), P§ . | 10-y CIR . | Unadjusted HR (99% CI), P‡ . | Adjusted HR (99% CI), P§ . | ||
| — | Normal karyotype | 90 | 38 | 49 | ||||||
| 1 | Abnormality of 1p | 68 | 4.13 (2.21-7.71), < .001 | 5.51 (2.81-10.80), < .001 | 20 | 2.58 (1.64-4.05), < .001 | 2.20 (1.57-3.08), < .001 | 58 | 1.64 (0.93-2.91), .03 | 1.62 (1.01-2.60), .008 |
| Abnormality of 1q | 63 | 5.19 (2.82-9.55), < .001 | 5.78 (3.02-11.07), < .001 | 21 | 2.26 (1.45-3.54), < .001 | 1.88 (1.33-2.65), < .001 | 55 | 1.26 (0.72-2.19), .3 | 1.30 (0.78-2.15), .19 | |
| 3 | Monosomy 3 | 46 | 10.16 (4.36-23.65), < .001 | 12.11 (5.02-29.19), < .001 | 3 | 24.46 (10.01-59.76), < .001 | 4.20 (2.68-6.58), < .001 | 82 | 75.92 (17.15-336.0), < .001 | 5.17 (2.68-9.96), < .001 |
| Abnormality of 3q | ||||||||||
| inv(3)(q21q26)/t(3;3)(q21;q26) | 36 | 15.33 (7.86-29.88), < .001 | 19.80 (9.79-40.07), < .001 | 3 | 13.22 (7.14-24.48), < .001 | 4.07 (2.89-5.72), < .001 | 89 | 14.41 (4.64-44.74), < .001 | 4.04 (2.22-7.36), < .001 | |
| t(3;5)(q21∼25;q31∼35) | 96 | 0.36 (0.03-5.06), .3 | 0.44 (0.03-6.51), .4 | 34 | 1.38 (0.66-2.90), .3 | 1.41 (0.72-2.77), .18 | 52 | 1.46 (0.61-3.50), .3 | 1.53 (0.72-3.25), .14 | |
| Other abnormality of 3q | 59 | 6.08 (3.56-10.38), < .001 | 6.98 (3.97-12.25), < .001 | 11.3 | 5.20 (3.32-8.14), < .001 | 2.77 (2.08-3.68), < .001 | 71 | 5.21 (2.70-10.05), < .001 | 2.71 (1.79-4.09), < .001 | |
| 4 | Trisomy 4 | 87 | 1.31 (0.51-3.33), .5 | 1.55 (0.57-4.24), .3 | 16 | 1.15 (0.74-1.80), .4 | 1.23 (0.80-1.88), .2 | 54 | 1.09 (0.64-1.83), .7 | 1.13 (0.68-1.87), .5 |
| 5 | Abnormality of 5q | |||||||||
| Monosomy 5 | 57 | 6.56 (4.02-10.72), < .001 | 7.58 (4.49-12.80), < .001 | 0 | 20.31 (12.70-32.47), < .001 | 4.33 (3.35-5.61), < .001 | 75 | 16.98 (8.42-34.23), < .001 | 3.80 (2.59-5.57), < .001 | |
| del(5q) | 58 | 6.22 (3.90-9.93), < .001 | 7.28 (4.40-12.06), < .001 | 12 | 5.14 (3.47-7.62), < .001 | 2.90 (2.23-3.76), < .001 | 64 | 3.02 (1.75-5.19), < .001 | 2.19 (1.47-3.27), < .001 | |
| add(5q) | 53 | 7.62 (3.83-15.17), < .001 | 10.38 (4.96-21.72), < .001 | 10 | 10.49 (5.34-20.60), < .001 | 3.58 (2.42-5.30), < .001 | 64 | 6.05 (2.25-16.28), < .001 | 2.84 (1.53-5.26), < .001 | |
| 6 | Trisomy 6 | 78 | 2.44 (1.10-5.41), .004 | 2.52 (1.11-5.73), .003 | 21 | 2.34 (1.40-3.92), < .001 | 1.88 (1.28-2.76), < .001 | 62 | 2.12 (1.12-4.01), .005 | 1.75 (1.08-2.85), .003 |
| t(6;9)(p23;q34) | 88 | 1.18 (0.34-4.06), .7 | 1.65 (0.47-5.82), .3 | 27 | 1.47 (0.77-2.81), .14 | 1.55 (0.88-2.74), .04 | 62 | 1.70 (0.76-3.79), .10 | 1.61 (0.82-3.16), .06 | |
| Abnormality of 6q, not t(6;11) | 63 | 5.05 (2.70-9.44), < .001 | 6.15 (3.16-11.96), < .001 | 21 | 2.52 (1.58-4.02), < .001 | 2.09 (1.47-2.96), < .001 | 53 | 1.32 (0.73-2.38), .2 | 1.33 (0.78-2.26), .17 | |
| 7 | Monosomy 7 | 58 | 6.37 (4.46-9.11), < .001 | 7.63 (5.18-11.24), < .001 | 8 | 5.57 (4.20-7.38), < .001 | 3.03 (2.50-3.67), < .001 | 70 | 4.38 (2.92-6.55), < .001 | 2.60 (1.98-3.42), < .001 |
| Abnormality of 7q | ||||||||||
| del(7q) | 77 | 2.64 (1.54-4.52), < .001 | 2.76 (1.56-4.89), < .001 | 26 | 1.66 (1.20-2.31), < .001 | 1.51 (1.14-1.98), < .001 | 57 | 1.32 (0.88-1.98), .08 | 1.26 (0.87-1.81), .11 | |
| add(7q) | 68 | 4.17 (2.09-8.30), < .001 | 5.08 (2.43-10.61), < .001 | 30 | 2.25 (1.34-3.79), < .001 | 1.97 (1.33-2.94), < .001 | 33 | 0.96 (0.50-1.85), .9 | 1.01 (0.52-1.98), 1.0 | |
| Abnormality of 7p | 65 | 4.69 (2.50-8.79), < .001 | 6.06 (3.09-11.92), < .001 | 22 | 2.18 (1.39-3.43), < .001 | 1.97 (1.39-2.80), < .001 | 61 | 1.30 (0.75-2.25), .2 | 1.31 (0.79-2.17), .17 | |
| 8 | Trisomy 8 | 80 | 2.20 (1.58-3.07), < .001 | 2.64 (1.85-3.77), < .001 | 37 | 1.21 (1.01-1.44), .006 | 1.32 (1.12-1.57), < .001 | 46 | 0.99 (0.80-1.23), .9 | 1.08 (0.87-1.35), .3 |
| t(8;21)(q22;q22) and variants | 97 | 0.26 (0.12-0.56), < .001 | 0.36 (0.16-0.81), < .001 | 61 | .58 (0.49-0.70), < .001 | 0.60 (0.47-0.75), < .001 | 27 | 0.54 (0.44-0.67), < .001 | 0.51 (0.39-0.68), < .001 | |
| Abnormality of 8p11∼12 | 91 | 0.83 (0.12-5.62), 0.8 | 1.32 (0.19-9.26), .7 | 50 | 0.91 (0.43-1.92), .8 | 1.22 (0.56-2.68), .5 | 49 | 1.08 (0.46-2.53), .8 | 1.31 (0.57-2.98), .4 | |
| 9 | Monosomy 9 | 68 | 4.10 (1.34-12.53), .001 | 5.01 (1.57-15.99), < .001 | 8 | 4.04 (1.69-9.67), < .001 | 2.55 (1.42-4.57), < .001 | 63 | 3.00 (0.92-9.78), .03 | 2.13 (0.89-5.06), .02 |
| t(9;22)(q34;q11) and variants | 72 | 3.43 (1.45-8.12), < .001 | 2.80 (1.08-7.27), .004 | 14 | 2.83 (1.53-5.23), < .001 | 1.91 (1.22-3.00), < .001 | 65 | 3.95 (1.59-9.83), < .001 | 2.32 (1.27-4.23), < .001 | |
| Deletion of 9q, including add(9q) | 86 | 1.39 (0.71-2.73), .2 | 1.82 (0.90-3.68), .03 | 47 | 0.80 (0.58-1.09), .05 | 0.83 (0.58-1.19), .19 | 35 | 0.66 (0.46-0.94), .001 | 0.60 (0.38-0.96), .005 | |
| 11 | Trisomy 11 | 75 | 2.86 (1.44-5.67), < .001 | 3.25 (1.57-6.71), < .001 | 13 | 2.26 (1.44-3.55), < .001 | 1.84 (1.30-2.61), < .001 | 71 | 2.71 (1.52-4.84), < .001 | 2.01 (1.31-3.08), < .001 |
| All 11q23 | ||||||||||
| t(9;11)(p21∼22;q23) | 84 | 1.71 (0.69-4.23), .13 | 2.13 (0.82-5.51), .03 | 39 | 1.24 (0.75-2.04), .3 | 1.36 (0.86-2.17), .08 | 44 | 1.00 (0.56-1.79), 1.0 | 1.04 (0.57-1.89), .9 | |
| t(10;11)(p11∼14;q13∼23) | 85 | 1.50 (0.43-5.29), .4 | 2.58 (0.70-9.53), .05 | 12 | 3.57 (1.71-7.45), < .001 | 3.29 (1.99-5.45), < .001 | 71 | 4.94 (1.95-12.55), < .001 | 3.39 (1.87-6.15), < .001 | |
| t(6;11)(q27;q23) | 96 | 0.40 (0.03-5.54), .4 | 0.63 (0.04-9.04), .6 | 9 | 2.80 (1.23-6.38), .004 | 2.56 (1.42-4.61), < .001 | 76 | 5.10 (1.79-14.52), < .001 | 2.97 (1.53-5.74), < .001 | |
| t(11;19)(q23;p13) | 97 | 0.30 (0.02-4.15), .2 | 0.45 (0.03-6.36), .4 | 49 | 0.89 (0.46-1.71), .7 | 1.11 (0.55-2.22), .7 | 44 | 1.03 (0.48-2.19), .9 | 1.21 (0.57-2.56), .5 | |
| Other 11q23 | 75 | 3.03 (1.41-6.53), < .001 | 3.87 (1.70-8.82), < .001 | 21 | 2.55 (1.52-4.27), < .001 | 2.07 (1.41-3.04), < .001 | 65 | 2.40 (1.26-4.59), .002 | 1.84 (1.12-3.03), .001 | |
| Abnormality of 11q (not 11q23) | 69 | 3.92 (2.27-6.76), < .001 | 4.86 (2.72-8.68), < .001 | 20 | 2.33 (1.59-3.42), < .001 | 2.13 (1.59-2.86), < .001 | 62 | 2.02 (1.23-3.32), < .001 | 1.90 (1.28-2.82), < .001 | |
| Abnormality of 11p13∼15 | 73 | 3.23 (1.23-8.50), .002 | 4.58 (1.66-12.64), < .001 | 26 | 1.61 (0.86-3.01), .06 | 1.48 (0.87-2.52), .06 | 53 | 1.08 (0.51-2.27), .8 | 1.02 (0.48-2.15), 1.0 | |
| 12 | Abnormality of 12p | |||||||||
| Monosomy 12 | 59 | 6.07 (2.95-12.48), < .001 | 6.54 (3.05-14.00), < .001 | 6 | 11.79 (5.98-23.28), < .001 | 3.67 (2.51-5.37), < .001 | 84 | 21.17 (7.65-58.60), < .001 | 4.48 (2.65-7.58), < .001 | |
| Other abnormality of 12p13 | 63 | 5.06 (2.31-11.06), < .001 | 6.00 (2.62-13.73), < .001 | 14 | 4.18 (2.21-7.90), < .001 | 2.58 (1.69-3.92), < .001 | 48 | 1.44 (0.64-3.22), .3 | 1.31 (0.64-2.69), .3 | |
| Other abnormality of 12p, not 12p13 | 57 | 6.57 (3.73-11.58), < .001 | 8.45 (4.57-15.62), < .001 | 17 | 4.12 (2.56-6.65), < .001 | 2.75 (1.98-3.82), < .001 | 53 | 1.78 (0.94-3.37), .03 | 1.61 (0.93-2.80), .02 | |
| 13 | Trisomy 13 | 70 | 3.75 (2.05-6.89), < .001 | 3.62 (1.90-6.90), < .001 | 9 | 2.54 (1.64-3.93), < .001 | 1.86 (1.34-2.57), < .001 | 72 | 1.82 (1.05-3.14), .009 | 1.56 (1.00-2.42), .008 |
| Abnormality of 13q | ||||||||||
| Monosomy 13 | 60 | 5.87 (3.09-11.16), < .001 | 7.07 (3.57-14.02), < .001 | 8 | 9.02 (5.06-16.07), < .001 | 3.48 (2.48-4.88), < .001 | 67 | 5.88 (2.65-13.06), < .001 | 2.90 (1.76-4.75), < .001 | |
| Deletion of 13q | 85 | 1.51 (0.37-6.18), .4 | 2.10 (0.49-9.02), .18 | 31 | 1.25 (0.64-2.46), .4 | 1.46 (0.78-2.75), .12 | 61 | 1.45 (0.65-3.26), .2 | 1.61 (0.80-3.24), .07 | |
| 15 | t(15;17)(q22;q21) and variants | 93 | 0.67 (0.43-1.04), .02 | 1.11 (0.69-1.76), .6 | 81 | 0.40 (0.34-0.47), < .001 | 0.30 (0.23-0.39), < .001 | 13 | 0.34 (0.29-0.41), < .001 | 0.19 (0.13-0.27), < .001 |
| Abnormality of 15q, not t(15;17) | 78 | 2.53 (0.94-6.81), .02 | 3.36 (1.15-9.83), .002 | 46 | 0.96 (0.53-1.72), .9 | 1.10 (0.60-2.03), .7 | 45 | 0.91 (0.44-1.85), .8 | 1.07 (0.50-2.25), .8 | |
| 16 | inv(16)(p13q22)/t(16;16)(p13;q22) | 92 | 0.81 (0.46-1.44), .3 | 0.88 (0.48-1.62), .6 | 55 | 0.66 (0.53-0.82), < .001 | 0.64 (0.49-0.84), < .001 | 46 | 0.86 (0.67-1.10), .10 | 0.85 (0.65-1.12), .12 |
| Abnormality of 16q, not inv(16) | 78 | 2.45 (1.25-4.82), < .001 | 2.85 (1.41-5.79), < .001 | 31 | 1.66 (1.10-2.51), .003 | 1.60 (1.13-2.26), < .001 | 58 | 1.44 (0.87-2.40), .07 | 1.36 (0.87-2.13), .08 | |
| 17 | Monosomy 17 | 56 | 6.76 (4.07-11.21), < .001 | 8.20 (4.78-14.09), < .001 | 3 | 15.22 (9.37-24.72), < .001 | 3.96 (3.02-5.19), < .001 | 80 | 13.68 (6.68-28.01), < .001 | 3.62 (2.43-5.41), < .001 |
| Abnormality of 17p | 68 | 4.08 (2.47-6.73), < .001 | 4.91 (2.86-8.41), < .001 | 25 | 2.50 (1.75-3.59), < .001 | 2.11 (1.60-2.78), < .001 | 56 | 1.84 (1.16-2.92), .002 | 1.75 (1.20-2.56), < .001 | |
| 18 | Monosomy 18 | 61 | 5.46 (3.10-9.63), < .001 | 6.04 (3.29-11.06), < .001 | 4 | 12.40 (7.28-21.11), < .001 | 3.57 (2.64-4.84), < .001 | 78 | 15.76 (7.21-34.42), < .001 | 3.61 (2.35-5.56), < .001 |
| 19 | Trisomy 19 | 81 | 2.04 (0.85-4.91), .04 | 2.28 (0.91-5.70), .02 | 12 | 3.11 (1.81-5.34), < .001 | 2.35 (1.61-3.42), < .001 | 74 | 3.97 (2.00-7.86), < .001 | 2.54 (1.62-3.99), < .001 |
| 20 | Monosomy 20 | 67 | 4.35 (1.99-9.54), < .001 | 4.96 (2.19-11.21), < .001 | 6 | 6.65 (3.43-12.89), < .001 | 2.98 (1.99-4.45), < .001 | 88 | 8.77 (3.68-20.89), < .001 | 3.10 (1.88-5.14), < .001 |
| Abnormality of 20q | 66 | 4.49 (2.00-10.12), < .001 | 4.93 (2.05-11.86), < .001 | 16 | 3.59 (1.86-6.94), < .001 | 2.59 (1.65-4.06), < .001 | 71 | 3.81 (1.54-9.42), .001 | 2.62 (1.44-4.77), < .001 | |
| 21 | Trisomy 21 (acquired) | 74 | 3.01 (1.79-5.07), < .001 | 3.36 (1.92-5.88), < .001 | 21 | 1.88 (1.35-2.62), < .001 | 1.69 (1.28-2.21), < .001 | 66 | 1.94 (1.28-2.96), < .001 | 1.69 (1.20-2.37), < .001 |
| Abnormality of 21q, not t(8;21) | 71 | 3.59 (1.80-7.15), < .001 | 4.10 (1.98-8.50), < .001 | 17 | 2.37 (1.44-3.88), < .001 | 1.93 (1.34-2.80), < .001 | 61 | 1.89 (0.99-3.57), .02 | 1.66 (1.00-2.75), .009 | |
| 22 | Trisomy 22 | 84 | 1.67 (0.84-3.31), .05 | 2.04 (1.00-4.14), .009 | 47 | 0.85 (0.61-1.19), .2 | 0.90 (0.63-1.30), .5 | 42 | 0.81 (0.55-1.20), .16 | 0.81 (0.52-1.26), .2 |
| X | Loss of X | 87 | 1.28 (0.60-2.74), .4 | 1.89 (0.86-4.15), .03 | 56 | 0.70 (0.51-0.97), .003 | 0.75 (0.50-1.12), .06 | 23 | 0.54 (0.37-0.78), < .001 | 0.44 (0.24-0.79), < .001 |
| Y | Loss of Y | 89 | 1.08 (0.59-1.99), .7 | 1.47 (0.79-2.74), .11 | 51 | 0.75 (0.58-0.96), .002 | 0.79 (0.59-1.06), .04 | 33 | 0.65 (0.48-0.86), < .001 | 0.62 (0.42-0.90), < .001 |
| Level of karyotype complexity | ||||||||||
| 1 abnormality | 87 | per abnormality: OR 1.37 (1.30-1.46), < .001 | per abnormality: OR 1.42 (1.33-1.51), < .001 | 47 | per abnormality HR 1.17 (1.13-1.20), < .001 | per abnormality: HR 1.19 (1.15-1.22), < .001 | 42 | per abnormality: HR 1.09 (1.04-1.13), < .001 | per abnormality HR 1.11 (1.06-1.16), < .001 | |
| 2 abnormalities | 85 | 45 | 40 | |||||||
| 3 abnormalities | 83 | 48 | 35 | |||||||
| 4 abnormalities | 74 | 30 | 51 | |||||||
| 5 or more abnormalities | 62 | 10 | 69 | |||||||
All odds ratios/hazard ratios are given compared with normal karyotype. CI indicates confidence interval; CIR, cumulative incidence of relapse; CR, complete remission; HR, hazard ratio; OR, odds ratio; and OS, overall survival.
Remission rates include CR with incomplete count recovery (CRi).
Method of analysis was logistic regression.
Method of analysis was log-rank test except for complexity (Cox regression).
Method of analysis was Cox regression.