Hypothesis-driven univariate analysis of HIV-1 transmission in the Jennes et al data set
| KIR with missing ligand . | At-risk partner’s KIR . | Index case’s HLA . | N couples with HIV transmission* . | N couples without HIV transmission* . | Odds ratio for HIV nontransmission† . | Odds ratio for HIV transmission . | P‡ . |
|---|---|---|---|---|---|---|---|
| Yes | 2DL1 | No C2 | 5 | 11 | 2.75 (0.84-9.00) | 0.36 (0.11-1.19) | .15 |
| No | Either: | 30 | 24 | 1.00 | 1.00 | ||
| 2DL1 | Any C2 | 27 | 19 | ||||
| No 2DL1 | Any | 3 | 5 | ||||
| Yes | 2DL3 (2DL3/2DL3) | No C1 | 5 | 5 | 1.04 (0.27-4.03) | 0.96 (0.25-3.73) | 1.0 |
| No | Either: | 26 | 25 | 1.00 | 1.00 | ||
| 2DL3/2DL3 | Any C1 | 15 | 6 | ||||
| 2DL2/2DL3 | Any | 9 | 11 | ||||
| 2DL2/2DL2 | Any | 2 | 8 | ||||
| Not published§ | Unknown? | 4 | 5 | —– | —– | ||
| Yes | 2DL2 (2DL2/2DL2, 2DL2/2DL3) | No C1 | 0 | 1 | Infinity | 0 | .49 |
| No | Either: | 31 | 29 | 1.00 | 1.00 | ||
| 2DL2 | Any C1 | 11 | 18 | ||||
| 2DL3/2DL3 | Any | 20 | 11 | ||||
| Not published§ | Unknown? | 4 | 5 | —– | —– |
| KIR with missing ligand . | At-risk partner’s KIR . | Index case’s HLA . | N couples with HIV transmission* . | N couples without HIV transmission* . | Odds ratio for HIV nontransmission† . | Odds ratio for HIV transmission . | P‡ . |
|---|---|---|---|---|---|---|---|
| Yes | 2DL1 | No C2 | 5 | 11 | 2.75 (0.84-9.00) | 0.36 (0.11-1.19) | .15 |
| No | Either: | 30 | 24 | 1.00 | 1.00 | ||
| 2DL1 | Any C2 | 27 | 19 | ||||
| No 2DL1 | Any | 3 | 5 | ||||
| Yes | 2DL3 (2DL3/2DL3) | No C1 | 5 | 5 | 1.04 (0.27-4.03) | 0.96 (0.25-3.73) | 1.0 |
| No | Either: | 26 | 25 | 1.00 | 1.00 | ||
| 2DL3/2DL3 | Any C1 | 15 | 6 | ||||
| 2DL2/2DL3 | Any | 9 | 11 | ||||
| 2DL2/2DL2 | Any | 2 | 8 | ||||
| Not published§ | Unknown? | 4 | 5 | —– | —– | ||
| Yes | 2DL2 (2DL2/2DL2, 2DL2/2DL3) | No C1 | 0 | 1 | Infinity | 0 | .49 |
| No | Either: | 31 | 29 | 1.00 | 1.00 | ||
| 2DL2 | Any C1 | 11 | 18 | ||||
| 2DL3/2DL3 | Any | 20 | 11 | ||||
| Not published§ | Unknown? | 4 | 5 | —– | —– |
KIR2DL2 and KIR2DL3 are alleles; thus, individuals have either 2 copies of 1 allele or 1 copy of each.
Numbers are derived from the percentages in Table 2 of Jennes et al. Numbers shown in italics are subtotals.
Nontransmission of HIV was the event of interest studied by Jennes et al. As shown, HIV transmission may also be studied.
Fisher’s exact test, 2-tailed, unadjusted for multiple hypothesis testing; P value applies equally to the 2 odds ratios in that row, each being an inversion of the other.
Nine subject-couples did not appear in the listing of 2DL2 and 2DL3 status in Table 2 of Jennes et al.