Flow-regulated genes involved in inflammation and cell growth and proliferation in mouse carotid endothelium
| Gene symbol . | 12-hour (LCA/RCA) . | FDR . | 48-hour (LCA/RCA) . | FDR . |
|---|---|---|---|---|
| Inflammation | ||||
| Down-regulated | ||||
| Col4a3 | 0.71 | > 10 | 0.22 | 8.1 |
| CCl11 | 1.41 | > 10 | 0.64 | 8.4 |
| CD40 | 0.88 | > 10 | 0.43 | 8.4 |
| CD59a | 0.93 | > 10 | 0.45 | 9.9 |
| Up-regulated | ||||
| Tyrobp | 2.93 | > 10 | 3.64 | 0.0 |
| CCl4 | 1.78 | > 10 | 2.41 | 3.1 |
| SELL | 1.47 | > 10 | 2.82 | 3.4 |
| Coro1a | 2.03 | > 10 | 6.70 | 7.5 |
| CD74 | 1.41 | > 10 | 3.80 | 8.6 |
| CD300a | 2.98 | > 10 | 4.31 | 9.5 |
| IL17RA | 2.01 | > 10 | 3.69 | 9.5 |
| Cxcl12 | 0.96 | > 10 | 3.43 | 9.5 |
| Cxcl16 | 1.32 | > 10 | 2.20 | 9.5 |
| SPP1 | ND | NA | 2.11 | 9.5 |
| ITGB2 | 1.15 | > 10 | 1.89 | 9.5 |
| TNFRSF1B | 1.46 | > 10 | 1.75 | 9.5 |
| IL1RN | ND | NA | 1.67 | 9.5 |
| VCAM1 | 1.47 | > 10 | 1.53 | 9.5 |
| Cell growth and proliferation | ||||
| Down-regulated | ||||
| KLF2 | 0.30 | 0.0 | 0.27 | 9.1 |
| ELN | 0.56 | 0.0 | 0.57 | 6.0 |
| Id1 | 0.59 | 0.0 | 0.45 | 0.0 |
| GNAQ | 0.66 | 0.0 | 0.76 | > 10 |
| PDGFA | 0.54 | 4.8 | 0.87 | > 10 |
| KLF4 | 0.48 | 7.2 | 0.28 | 8.1 |
| KRAS | 0.54 | 7.2 | 0.63 | 8.6 |
| CDKN1A | 0.54 | 7.2 | 1.31 | > 10 |
| F2RL1 | 0.56 | 7.2 | 0.60 | 6.9 |
| Pthlh | 0.42 | > 10 | 0.24 | 0.0 |
| IGF2 | 0.85 | > 10 | 0.29 | 9.1 |
| MAP3K1 | 1.03 | > 10 | 0.60 | 8.1 |
| Up-regulated | ||||
| BMP4 | 1.54 | 0.0 | 1.37 | > 10 |
| FOSL2 | 1.79 | 9.6 | 1.71 | 3.4 |
| BCL2L11 | 1.44 | > 10 | 1.84 | 9.5 |
| Gene symbol . | 12-hour (LCA/RCA) . | FDR . | 48-hour (LCA/RCA) . | FDR . |
|---|---|---|---|---|
| Inflammation | ||||
| Down-regulated | ||||
| Col4a3 | 0.71 | > 10 | 0.22 | 8.1 |
| CCl11 | 1.41 | > 10 | 0.64 | 8.4 |
| CD40 | 0.88 | > 10 | 0.43 | 8.4 |
| CD59a | 0.93 | > 10 | 0.45 | 9.9 |
| Up-regulated | ||||
| Tyrobp | 2.93 | > 10 | 3.64 | 0.0 |
| CCl4 | 1.78 | > 10 | 2.41 | 3.1 |
| SELL | 1.47 | > 10 | 2.82 | 3.4 |
| Coro1a | 2.03 | > 10 | 6.70 | 7.5 |
| CD74 | 1.41 | > 10 | 3.80 | 8.6 |
| CD300a | 2.98 | > 10 | 4.31 | 9.5 |
| IL17RA | 2.01 | > 10 | 3.69 | 9.5 |
| Cxcl12 | 0.96 | > 10 | 3.43 | 9.5 |
| Cxcl16 | 1.32 | > 10 | 2.20 | 9.5 |
| SPP1 | ND | NA | 2.11 | 9.5 |
| ITGB2 | 1.15 | > 10 | 1.89 | 9.5 |
| TNFRSF1B | 1.46 | > 10 | 1.75 | 9.5 |
| IL1RN | ND | NA | 1.67 | 9.5 |
| VCAM1 | 1.47 | > 10 | 1.53 | 9.5 |
| Cell growth and proliferation | ||||
| Down-regulated | ||||
| KLF2 | 0.30 | 0.0 | 0.27 | 9.1 |
| ELN | 0.56 | 0.0 | 0.57 | 6.0 |
| Id1 | 0.59 | 0.0 | 0.45 | 0.0 |
| GNAQ | 0.66 | 0.0 | 0.76 | > 10 |
| PDGFA | 0.54 | 4.8 | 0.87 | > 10 |
| KLF4 | 0.48 | 7.2 | 0.28 | 8.1 |
| KRAS | 0.54 | 7.2 | 0.63 | 8.6 |
| CDKN1A | 0.54 | 7.2 | 1.31 | > 10 |
| F2RL1 | 0.56 | 7.2 | 0.60 | 6.9 |
| Pthlh | 0.42 | > 10 | 0.24 | 0.0 |
| IGF2 | 0.85 | > 10 | 0.29 | 9.1 |
| MAP3K1 | 1.03 | > 10 | 0.60 | 8.1 |
| Up-regulated | ||||
| BMP4 | 1.54 | 0.0 | 1.37 | > 10 |
| FOSL2 | 1.79 | 9.6 | 1.71 | 3.4 |
| BCL2L11 | 1.44 | > 10 | 1.84 | 9.5 |