Table 9 Cladribine and fludarabine... | American Society of Hematology

Table 9

Cladribine and fludarabine toxicities

Study/regimen	Phase	Disease	Grade 3 or 4
Study/regimen	Phase	Disease	Neutropenia, %	Thrombocytopenia, %	Infections, %
Roback et al (2000)⁸⁶
2-CdA + P	3	CLL	9	9	56 (all grades)
Robak et al (2004)⁴²
2-CdA + R	2	CLL and NHL (previously treated)	12	13	27
Karlsson et al (2007)⁸⁵
2-CdA	3	CLL	57	43	36
F	3	CLL	34	24	24
Robak et al (2010)⁸⁸
2-CdA + Cy	3	CLL	20	12	28
F + Cy	3	CLL	21	11	27

Study/regimen	Phase	Disease	Grade 3 or 4
Study/regimen	Phase	Disease	Neutropenia, %	Thrombocytopenia, %	Infections, %
Roback et al (2000)⁸⁶
2-CdA + P	3	CLL	9	9	56 (all grades)
Robak et al (2004)⁴²
2-CdA + R	2	CLL and NHL (previously treated)	12	13	27
Karlsson et al (2007)⁸⁵
2-CdA	3	CLL	57	43	36
F	3	CLL	34	24	24
Robak et al (2010)⁸⁸
2-CdA + Cy	3	CLL	20	12	28
F + Cy	3	CLL	21	11	27

2-CdA indicates cladribine; P, prednisone; R, rituximab; F, fludarabine; and Cy, cyclophosphamide.