Phase 2 studies of single-agent cladribine in previously untreated indolent NHL
| Study . | Cladribine doses . | Histology, % . | Response, % . | Median duration, mo . | ||
|---|---|---|---|---|---|---|
| Follicular . | Other . | OR . | CR . | |||
| Saven et al (1995)48 | A | 36 | 64 | 88 | 35 | 10 |
| Betticher et al (1996)49 | B | 100 | 0 | 85 | 24 | > 14 |
| Canfield et al (1997)50 | A | 92 | 8 | 64 | 8 | > 14 |
| Fridrik et al (1998)51 | C | 57 | 43 | 88 | 27 | 21 |
| Liliemark et al (1998)52 | C | 50 | 50 | 64 | 25 | 7 |
| Rummel et al (1999)47 | D | 39 | 61 | 76 | 38 | 23 |
| Blum et al (2006)46 | E | 74 | 26 | 98 | 32 | 23 |
| Study . | Cladribine doses . | Histology, % . | Response, % . | Median duration, mo . | ||
|---|---|---|---|---|---|---|
| Follicular . | Other . | OR . | CR . | |||
| Saven et al (1995)48 | A | 36 | 64 | 88 | 35 | 10 |
| Betticher et al (1996)49 | B | 100 | 0 | 85 | 24 | > 14 |
| Canfield et al (1997)50 | A | 92 | 8 | 64 | 8 | > 14 |
| Fridrik et al (1998)51 | C | 57 | 43 | 88 | 27 | 21 |
| Liliemark et al (1998)52 | C | 50 | 50 | 64 | 25 | 7 |
| Rummel et al (1999)47 | D | 39 | 61 | 76 | 38 | 23 |
| Blum et al (2006)46 | E | 74 | 26 | 98 | 32 | 23 |
A indicates 0.1 mg/kg per day as continuous intravenous infusion for 7 days; B, 0.1 mg/kg per day as continuous intravenous or subcutaneous infusion for 7 days; C, 0.12 mg/kg per day as 2-hour intravenous infusion for 5 consecutive days; D, 5 mg/m2 2-hour intravenous infusion for 5 consecutive days; and E, 0.14 mg/kg per day as 2-hour intravenous infusion for 5 consecutive days.