Table 3 Summary of prognostic regions... | American Society of Hematology

Table 3

Summary of prognostic regions and genes tested

Copy number abnormality	Prognostic significance	Genes identified	Gene function
del(1p)	Yes	FAF1*	Fas associated
del(1p)	Yes	CDKN2C*	Cell-cycle inhibitor
1q+	Yes	CKS1B*	Cyclin-dependent kinase
1q+	Yes	ANP32E†	Histone acetyltransferase inhibitor
del(8p)	No	NA	NA
del(13q)	No‡	NA	NA
del(16q)	No	NA	NA
del(17p)	Yes	TP53*	Regulator of transcription

Copy number abnormality	Prognostic significance	Genes identified	Gene function
del(1p)	Yes	FAF1*	Fas associated
del(1p)	Yes	CDKN2C*	Cell-cycle inhibitor
1q+	Yes	CKS1B*	Cyclin-dependent kinase
1q+	Yes	ANP32E†	Histone acetyltransferase inhibitor
del(8p)	No	NA	NA
del(13q)	No‡	NA	NA
del(16q)	No	NA	NA
del(17p)	Yes	TP53*	Regulator of transcription

NA indicates not applicable.

Significant by fluorescence in situ hybridization (FISH).

Significant by expression quartile analysis.

Not significant by FISH when del(17p), t(4;14), t(14;16), and t(14;20) samples are removed from the analysis.