Additional genetic lesions that have an impact on outcomes in patients with Ph+ ALL
| Factor affecting prognosis . | Normal role . | Mode of detection . | Frequency of occurrence in Ph+ ALL . | Suggestive cytogenetic lesion . | References . |
|---|---|---|---|---|---|
| IKZF1 (IKAROS) deletions | A transcription factor required for lymphoid development | SNP array | 75%-80% | Deletions of chromosome 7 | 6,12,–14 |
| PAX5 Deletions, fusions, and amplifications | Transcription factor required for lymphoid development | SNP array, RAC-RACE, PCR | 50% | Deletions of chromosome 9 | 15,16 |
| CDKN2A/B deletions | A tumor suppressor gene complex | SNP array | 50%-60% | Deletions of chromosome 9 | 6 |
| Factor affecting prognosis . | Normal role . | Mode of detection . | Frequency of occurrence in Ph+ ALL . | Suggestive cytogenetic lesion . | References . |
|---|---|---|---|---|---|
| IKZF1 (IKAROS) deletions | A transcription factor required for lymphoid development | SNP array | 75%-80% | Deletions of chromosome 7 | 6,12,–14 |
| PAX5 Deletions, fusions, and amplifications | Transcription factor required for lymphoid development | SNP array, RAC-RACE, PCR | 50% | Deletions of chromosome 9 | 15,16 |
| CDKN2A/B deletions | A tumor suppressor gene complex | SNP array | 50%-60% | Deletions of chromosome 9 | 6 |
Ph+ ALL indicates Philadelphia chromosome–positive acute lymphoblastic leukemia; RAC-RACE, rolling circle amplification–rapid amplification of cDNA ends; PCR, polymerase chain reaction; and SNP, single nucleotide polymorphism.