Relative risk of selected severe (grade 3) or life-threatening/disabling (grade 4) chronic health conditions among HCT survivors compared with siblings
| Grade 3 or grade 4 condition . | Survivors (N = 1022), percentage . | Siblings (N = 309), percentage . | RR (95% CI)* . | Autologous HCT survivors, percentage . | RR (95% CI)* . | Allogeneic HCT survivors without chronic GVHD, percentage . | RR (95% CI)* . | Allogeneic HCT survivors with chronic GVHD, percentage . | RR (95% CI)* . |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular | 6.8 | 2.6 | 2.85 (1.37-5.90) | 7.2 | 2.70 (1.25-5.86) | 6.1 | 3.01 (1.33-6.83) | 7.2 | 2.99 (1.33-6.77) |
| Coronary artery disease | 1.8 | 1.6 | 2.0 | 1.1 | 2.0 | ||||
| Congestive heart failure | 0.5 | 0 | 1.1 | 0 | 0 | ||||
| Stroke | 1.4 | 0.3 | 0.4 | 2.7 | 1.6 | ||||
| Auditory or visual impairment | 2.6 | 1.0 | 2.89 (0.88-9.47) | 1.8 | 1.96 (0.51-7.49) | 3.4 | 3.64 (1.02-12.94) | 3.3 | 3.81 (1.07-13.53) |
| Legally blind or loss of an eye | 1.5 | 0 | 0.4 | 2.7 | 2.0 | ||||
| Hearing loss not corrected by aid | 1.2 | 1.0 | 1.3 | 0.8 | 1.3 | ||||
| Gastrointestinal | 2.9 | 0.7 | 4.33 (1.03-18.13) | 1.8 | 2.40 (0.51-11.44) | 2.7 | 4.73 (0.95-23.51) | 4.9 | 7.70 (1.73-34.28) |
| Surgery for intestinal obstruction/colostomy | 1.4 | 0 | 1.3 | 0 | 2.6 | ||||
| Rectal or anal stricture | 0.9 | 0.7 | 0.7 | 1.1 | 1.0 | ||||
| Cirrhosis | 0.8 | 0 | 0 | 1.5 | 1.3 | ||||
| Endocrine | 2.4 | 1.0 | 2.36 (0.73-7.61) | 1.5 | 1.56 (0.42-5.82) | 2.7 | 2.75 (0.67-11.18) | 3.3 | 3.40 (0.94-12.22) |
| Diabetes | 1.9 | 0.7 | 0.7 | 2.3 | 3.3 | ||||
| Musculoskeletal problems | 3.4 | 0.7 | 5.08 (1.23-21.10) | 2.0 | 2.53 (0.56-11.55) | 2.3 | 4.67 (0.91-23.97) | 6.6 | 10.87 (2.47-47.95) |
| Joint replacement | 3.4 | 0.7 | 2.0 | 2.3 | 6.6 | ||||
| Renal | 0.5 | 0 | — | 0.4 | 0.8 | 0 | |||
| Dialysis support | 0.5 | 0 | 0.4 | 0.8 | 0 | ||||
| New malignancies | 2.5 | 2.9 | 0.87 (0.41-1.84) | 2.6 | 0.84 (0.34-2.05) | 3.8 | 1.57 (0.68-3.60) | 1.0 | 0.37 (0.10-1.31) |
| Grade 3 or grade 4 condition . | Survivors (N = 1022), percentage . | Siblings (N = 309), percentage . | RR (95% CI)* . | Autologous HCT survivors, percentage . | RR (95% CI)* . | Allogeneic HCT survivors without chronic GVHD, percentage . | RR (95% CI)* . | Allogeneic HCT survivors with chronic GVHD, percentage . | RR (95% CI)* . |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular | 6.8 | 2.6 | 2.85 (1.37-5.90) | 7.2 | 2.70 (1.25-5.86) | 6.1 | 3.01 (1.33-6.83) | 7.2 | 2.99 (1.33-6.77) |
| Coronary artery disease | 1.8 | 1.6 | 2.0 | 1.1 | 2.0 | ||||
| Congestive heart failure | 0.5 | 0 | 1.1 | 0 | 0 | ||||
| Stroke | 1.4 | 0.3 | 0.4 | 2.7 | 1.6 | ||||
| Auditory or visual impairment | 2.6 | 1.0 | 2.89 (0.88-9.47) | 1.8 | 1.96 (0.51-7.49) | 3.4 | 3.64 (1.02-12.94) | 3.3 | 3.81 (1.07-13.53) |
| Legally blind or loss of an eye | 1.5 | 0 | 0.4 | 2.7 | 2.0 | ||||
| Hearing loss not corrected by aid | 1.2 | 1.0 | 1.3 | 0.8 | 1.3 | ||||
| Gastrointestinal | 2.9 | 0.7 | 4.33 (1.03-18.13) | 1.8 | 2.40 (0.51-11.44) | 2.7 | 4.73 (0.95-23.51) | 4.9 | 7.70 (1.73-34.28) |
| Surgery for intestinal obstruction/colostomy | 1.4 | 0 | 1.3 | 0 | 2.6 | ||||
| Rectal or anal stricture | 0.9 | 0.7 | 0.7 | 1.1 | 1.0 | ||||
| Cirrhosis | 0.8 | 0 | 0 | 1.5 | 1.3 | ||||
| Endocrine | 2.4 | 1.0 | 2.36 (0.73-7.61) | 1.5 | 1.56 (0.42-5.82) | 2.7 | 2.75 (0.67-11.18) | 3.3 | 3.40 (0.94-12.22) |
| Diabetes | 1.9 | 0.7 | 0.7 | 2.3 | 3.3 | ||||
| Musculoskeletal problems | 3.4 | 0.7 | 5.08 (1.23-21.10) | 2.0 | 2.53 (0.56-11.55) | 2.3 | 4.67 (0.91-23.97) | 6.6 | 10.87 (2.47-47.95) |
| Joint replacement | 3.4 | 0.7 | 2.0 | 2.3 | 6.6 | ||||
| Renal | 0.5 | 0 | — | 0.4 | 0.8 | 0 | |||
| Dialysis support | 0.5 | 0 | 0.4 | 0.8 | 0 | ||||
| New malignancies | 2.5 | 2.9 | 0.87 (0.41-1.84) | 2.6 | 0.84 (0.34-2.05) | 3.8 | 1.57 (0.68-3.60) | 1.0 | 0.37 (0.10-1.31) |
Adjusted for age at study participation, race, and sex.