HCT survivors and siblings with a chronic health condition, according to severity score*
| Health condition . | Survivors (N = 1022) . | Autologous HCT . | Allogeneic HCT . | No recurrence . | Yes recurrence . | Siblings (N = 309) . | P, comparison of all HCT survivors with siblings . | ||
|---|---|---|---|---|---|---|---|---|---|
| All allogeneic HCT . | Without chronic GVHD . | With chronic GVHD . | |||||||
| No condition | 343 (33.6) | 180 (39.3) | 163 (28.9) | 83 (31.6) | 80 (26.7) | 296 (33.3) | 47 (35.3) | 189 (61.2) | < .001 |
| Grade 1 | 147 (14.4) | 78 (17.0) | 69 (12.2) | 37 (14.1) | 32 (10.7) | 127 (14.3) | 20 (15.0) | 45 (14.6) | |
| Grade 2 | 345 (33.8) | 129 (28.2) | 216 (38.3) | 96 (36.5) | 120 (40.0) | 300 (33.8) | 45 (33.8) | 51 (16.5) | |
| Grade 3 | 144 (14.1) | 53 (11.6) | 91 (16.1) | 30 (11.4) | 60 (20.0) | 128 (14.4) | 16 (12.0) | 15 (4.9) | |
| Grade 4 | 43 (4.2) | 18 (3.9) | 25 (4.4) | 17 (6.5) | 8 (2.7) | 38 (4.3) | 5 (3.8) | 9 (2.9) | |
| Any condition | |||||||||
| Grades 1-4 | 679 (66.4) | 278 (60.7) | 401 (71.1) | 180 (68.4) | 220 (73.3) | 593 (66.7) | 86 (64.7) | 120 (38.8) | < .001 |
| Grade 1 or 2† | 662 (64.8) | 271 (59.2) | 391 (69.3) | 172 (65.4) | 218 (72.7) | 577 (64.9) | 85 (63.9) | 112 (36.3) | < .001 |
| Grade 3 or 4† | 187 (18.3) | 71 (15.5) | 116 (20.6) | 47 (17.9) | 68 (22.7) | 166 (18.7) | 21 (15.8) | 24 (7.8) | < .001 |
| No. of multiple health conditions | |||||||||
| ≥ 2 | 515 (50.4) | 200 (43.7) | 315 (55.9) | 128 (48.7) | 186 (62.0) | 444 (49.9) | 71 (53.4) | 46 (14.9) | < .001 |
| ≥ 3 | 353 (34.5) | 118 (25.8) | 235 (41.7) | 89 (22.8) | 145 (48.3) | 313 (35.2) | 40 (30.1) | 17 (5.5) | < .001 |
| Median (range) | 3 (1-16) | 2 (1-14) | 3 (1-16) | 2 (1-16) | 4 (1-15) | 3 (1-16) | 2 (1-14) | 1 (1-7) | < .001 |
| Health condition . | Survivors (N = 1022) . | Autologous HCT . | Allogeneic HCT . | No recurrence . | Yes recurrence . | Siblings (N = 309) . | P, comparison of all HCT survivors with siblings . | ||
|---|---|---|---|---|---|---|---|---|---|
| All allogeneic HCT . | Without chronic GVHD . | With chronic GVHD . | |||||||
| No condition | 343 (33.6) | 180 (39.3) | 163 (28.9) | 83 (31.6) | 80 (26.7) | 296 (33.3) | 47 (35.3) | 189 (61.2) | < .001 |
| Grade 1 | 147 (14.4) | 78 (17.0) | 69 (12.2) | 37 (14.1) | 32 (10.7) | 127 (14.3) | 20 (15.0) | 45 (14.6) | |
| Grade 2 | 345 (33.8) | 129 (28.2) | 216 (38.3) | 96 (36.5) | 120 (40.0) | 300 (33.8) | 45 (33.8) | 51 (16.5) | |
| Grade 3 | 144 (14.1) | 53 (11.6) | 91 (16.1) | 30 (11.4) | 60 (20.0) | 128 (14.4) | 16 (12.0) | 15 (4.9) | |
| Grade 4 | 43 (4.2) | 18 (3.9) | 25 (4.4) | 17 (6.5) | 8 (2.7) | 38 (4.3) | 5 (3.8) | 9 (2.9) | |
| Any condition | |||||||||
| Grades 1-4 | 679 (66.4) | 278 (60.7) | 401 (71.1) | 180 (68.4) | 220 (73.3) | 593 (66.7) | 86 (64.7) | 120 (38.8) | < .001 |
| Grade 1 or 2† | 662 (64.8) | 271 (59.2) | 391 (69.3) | 172 (65.4) | 218 (72.7) | 577 (64.9) | 85 (63.9) | 112 (36.3) | < .001 |
| Grade 3 or 4† | 187 (18.3) | 71 (15.5) | 116 (20.6) | 47 (17.9) | 68 (22.7) | 166 (18.7) | 21 (15.8) | 24 (7.8) | < .001 |
| No. of multiple health conditions | |||||||||
| ≥ 2 | 515 (50.4) | 200 (43.7) | 315 (55.9) | 128 (48.7) | 186 (62.0) | 444 (49.9) | 71 (53.4) | 46 (14.9) | < .001 |
| ≥ 3 | 353 (34.5) | 118 (25.8) | 235 (41.7) | 89 (22.8) | 145 (48.3) | 313 (35.2) | 40 (30.1) | 17 (5.5) | < .001 |
| Median (range) | 3 (1-16) | 2 (1-14) | 3 (1-16) | 2 (1-16) | 4 (1-15) | 3 (1-16) | 2 (1-14) | 1 (1-7) | < .001 |
Values are n (%).
The severity of health conditions was scored according to the Common Terminology Criteria for Adverse Events, Version 3. Health conditions of HCT survivors did not include conditions that patients had before HCT or acute conditions they had within 2 years after the HCT.
The number of patients in each subgroup may not reflect the sum of grades of conditions because grades 1 to 4 were calculated by taking the maximum grade per subject. A subject with higher-grade condition may have other lower-grade conditions.