Table 3

Multivariate analysis of prognostic factors

PHR95% CI
3-year LFS (n = 543)    
    Age at transplantation > 47 y .92 0.99 0.77-1.27 
    CD34+ > 7.16 × 106/kg .027 0.73 0.55-0.96 
    WBC at diagnosis > 15 × 109/kg .18 0.84 0.65-1.08 
    Good cytogenetics versus other < .001 2.86 1.79-4.55 
    No. of induction courses > 1 < .001 0.50 0.36-0.68 
    No. of consolidation courses to collection ≥ 2 .64 1.06 0.83-1.37 
    TBI .25 1.28 0.84-1.96 
    Center .3   
3-year relapse (n = 543)    
    Age at transplantation > 47 y .67 0.94 0.72-1.23 
    CD34+ > 7.16 × 106/kg .013 1.46 1.08-1.98 
    WBC at diagnosis > 15 × 109/kg .22 1.19 0.9-1.56 
    Good cytogenetics versus other < .001 0.35 0.21-0.58 
    No. of induction courses > 1 < .001 1.96 1.37-2.79 
    No. of consolidation courses to collection ≥ 2 .16 0.82 0.63-1.08 
    TBI .53 0.87 0.57-1.34 
    Center .91   
3-year NRM    
    Age at transplantation > 47 y .22 1.49 0.79-2.82 
    CD34+ > 7.16 × 106/kg .79 0.9 0.39-2.03 
    WBC at diagnosis > 15 × 109/kg .66 1.15 0.62-2.14 
    Good cytogenetics versus other .1 0.36 0.11-1.19 
    No. of induction courses > 1 .03 2.27 1.07-4.82 
    No. of consolidation courses to collection ≥ 2 .04 1.96 1.02-3.77 
    TBI .14 0.22 0.03-1.64 
    Center .2   
PHR95% CI
3-year LFS (n = 543)    
    Age at transplantation > 47 y .92 0.99 0.77-1.27 
    CD34+ > 7.16 × 106/kg .027 0.73 0.55-0.96 
    WBC at diagnosis > 15 × 109/kg .18 0.84 0.65-1.08 
    Good cytogenetics versus other < .001 2.86 1.79-4.55 
    No. of induction courses > 1 < .001 0.50 0.36-0.68 
    No. of consolidation courses to collection ≥ 2 .64 1.06 0.83-1.37 
    TBI .25 1.28 0.84-1.96 
    Center .3   
3-year relapse (n = 543)    
    Age at transplantation > 47 y .67 0.94 0.72-1.23 
    CD34+ > 7.16 × 106/kg .013 1.46 1.08-1.98 
    WBC at diagnosis > 15 × 109/kg .22 1.19 0.9-1.56 
    Good cytogenetics versus other < .001 0.35 0.21-0.58 
    No. of induction courses > 1 < .001 1.96 1.37-2.79 
    No. of consolidation courses to collection ≥ 2 .16 0.82 0.63-1.08 
    TBI .53 0.87 0.57-1.34 
    Center .91   
3-year NRM    
    Age at transplantation > 47 y .22 1.49 0.79-2.82 
    CD34+ > 7.16 × 106/kg .79 0.9 0.39-2.03 
    WBC at diagnosis > 15 × 109/kg .66 1.15 0.62-2.14 
    Good cytogenetics versus other .1 0.36 0.11-1.19 
    No. of induction courses > 1 .03 2.27 1.07-4.82 
    No. of consolidation courses to collection ≥ 2 .04 1.96 1.02-3.77 
    TBI .14 0.22 0.03-1.64 
    Center .2   

LFS indicates leukemia-free survival; HR, hazard ratio; CI, confidence interval; WBC, white blood cell count; TBI, total body irradiation; and NRM, nonrelapse mortality.

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