Table 2

Main characteristics of cohort studies evaluating the association between blood transfusions and non-Hodgkin lymphoma

AuthorYearCountrySource of cohortNHL assessmentRBC transfusion assessmentMean follow-upTotal cohort (total person-years)Cases observed (cases expected)Source of expected casesAdjustments
Blomberg14  1993 Sweden Blood Centre Registry, Lund University Hospital Regional tumor registry Blood Centre Registry, Lund University Hospital 10 y (1981-1991) 1572 (8249) 7 (1.7) Malmohus County Council Registry Age 
Memon18  1994 United Kingdom 41 major hospitals and blood centers in England, Wales, and Scotland National Health Service Central Registry 41 major hospitals and blood centers in England, Wales, and Scotland 25 y (1942-1990) 12 690 (340 227) 4 (1.85) National Health Service Central Registry NR 
Cerhan15  2001 United States Iowa Women's Health Study State Health Registry of Iowa Mailed questionnaire 12 y (1986-1997) 37 934 (418 342) 40 (NR) NR Age, marital status, residence, smoking, alcohol intake, diabetes, and diet 
Hjalgrim17  2007 Sweden, Denmark Scandinavian Donation and Transfusion (SCANDAT) database National Cancer Registry and Hospital Registers Scandinavian Donation and Transfusion (SCANDAT) database Varied (Sweden, 1968-2002; Denmark, 1982-2002) 888 843 (5 652 918) 2853 (NR) Incidence rates from the general populations of Sweden and Denmark Age, sex, and country 
Erber16  2009 United States (Los Angeles, Hawaii) Multiethnic Cohort (MEC) study Hawaii Tumor Registry, Los Angeles County Cancer Surveillance Program, State of California Cancer Registry Mailed questionnaire 10 y (started between 1993 and 1996) 193 050 (NR) 939 (NR) NR Ethnicity, education, body mass index and alcohol intake 
AuthorYearCountrySource of cohortNHL assessmentRBC transfusion assessmentMean follow-upTotal cohort (total person-years)Cases observed (cases expected)Source of expected casesAdjustments
Blomberg14  1993 Sweden Blood Centre Registry, Lund University Hospital Regional tumor registry Blood Centre Registry, Lund University Hospital 10 y (1981-1991) 1572 (8249) 7 (1.7) Malmohus County Council Registry Age 
Memon18  1994 United Kingdom 41 major hospitals and blood centers in England, Wales, and Scotland National Health Service Central Registry 41 major hospitals and blood centers in England, Wales, and Scotland 25 y (1942-1990) 12 690 (340 227) 4 (1.85) National Health Service Central Registry NR 
Cerhan15  2001 United States Iowa Women's Health Study State Health Registry of Iowa Mailed questionnaire 12 y (1986-1997) 37 934 (418 342) 40 (NR) NR Age, marital status, residence, smoking, alcohol intake, diabetes, and diet 
Hjalgrim17  2007 Sweden, Denmark Scandinavian Donation and Transfusion (SCANDAT) database National Cancer Registry and Hospital Registers Scandinavian Donation and Transfusion (SCANDAT) database Varied (Sweden, 1968-2002; Denmark, 1982-2002) 888 843 (5 652 918) 2853 (NR) Incidence rates from the general populations of Sweden and Denmark Age, sex, and country 
Erber16  2009 United States (Los Angeles, Hawaii) Multiethnic Cohort (MEC) study Hawaii Tumor Registry, Los Angeles County Cancer Surveillance Program, State of California Cancer Registry Mailed questionnaire 10 y (started between 1993 and 1996) 193 050 (NR) 939 (NR) NR Ethnicity, education, body mass index and alcohol intake 

NHL indicates non-Hodgkin lymphoma; RBC, red blood cell; and NR, not reported.

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