Table 1

miRNAs affecting fibrinogen synthesis

miRNA IDFold change in fibrinogen production (log2)*Relative change in fibrinogen production, percentage†P‡Expression in liver and HuH7
Down-regulators     
    hsa-miR-29a −1.46 −63.6 .0132 E 
    hsa-miR-218 −1.23 −57.3 .0144 E 
    hsa-miR-409-3p −0.88 −45.5 .0448 E§ 
    hsa-miR-200c −0.86 −44.8 .0146 E 
    hsa-miR-29c −0.83 −43.7 .0434 E 
    hsa-miR-425-5p −0.82 −43.2 .0114 E 
    hsa-miR-195 −0.80 −42.7 .0058 E 
    hsa-miR-199b −0.79 −42.2 .0428 E 
    hsa-miR-31 −0.77 −41.5 .0208 E 
    hsa-miR-429 −0.77 −41.3 .0388 E 
    hsa-miR-197 −0.67 −37.0 .0180 E 
    hsa-miR-28 −0.63 −35.3 .0176 E 
    hsa-miR-22 −0.63 −35.2 .0086 E 
    hsa-miR-574 −0.59 −33.7 .0420 E 
    hsa-miR-23b −0.58 −33.2 .0028 E 
    hsa-let-7e −0.57 −32.7 .0500 E 
    hsa-let-7d −0.56 −32.0 .0484 E 
    hsa-miR-132 −0.53 −30.8 .0048 E 
    hsa-miR-215 −0.46 −27.3 .0310 E 
    hsa-miR-24 −0.45 −26.6 .0264 E 
    hsa-miR-182 −0.44 −26.4 .0194 E 
    hsa-miR-19b −0.44 −26.4 .0346 E 
    hsa-miR-194 −0.42 −25.5 .0412 E 
Up-regulators     
    hsa-miR-769-5p 0.34 26.2 .0066 E 
    hsa-miR-592 0.44 35.9 .0472 E 
    hsa-miR-126 0.46 37.6 .0022 E 
    hsa-miR-365 1.20 129.3 .0474 E 
miRNA IDFold change in fibrinogen production (log2)*Relative change in fibrinogen production, percentage†P‡Expression in liver and HuH7
Down-regulators     
    hsa-miR-29a −1.46 −63.6 .0132 E 
    hsa-miR-218 −1.23 −57.3 .0144 E 
    hsa-miR-409-3p −0.88 −45.5 .0448 E§ 
    hsa-miR-200c −0.86 −44.8 .0146 E 
    hsa-miR-29c −0.83 −43.7 .0434 E 
    hsa-miR-425-5p −0.82 −43.2 .0114 E 
    hsa-miR-195 −0.80 −42.7 .0058 E 
    hsa-miR-199b −0.79 −42.2 .0428 E 
    hsa-miR-31 −0.77 −41.5 .0208 E 
    hsa-miR-429 −0.77 −41.3 .0388 E 
    hsa-miR-197 −0.67 −37.0 .0180 E 
    hsa-miR-28 −0.63 −35.3 .0176 E 
    hsa-miR-22 −0.63 −35.2 .0086 E 
    hsa-miR-574 −0.59 −33.7 .0420 E 
    hsa-miR-23b −0.58 −33.2 .0028 E 
    hsa-let-7e −0.57 −32.7 .0500 E 
    hsa-let-7d −0.56 −32.0 .0484 E 
    hsa-miR-132 −0.53 −30.8 .0048 E 
    hsa-miR-215 −0.46 −27.3 .0310 E 
    hsa-miR-24 −0.45 −26.6 .0264 E 
    hsa-miR-182 −0.44 −26.4 .0194 E 
    hsa-miR-19b −0.44 −26.4 .0346 E 
    hsa-miR-194 −0.42 −25.5 .0412 E 
Up-regulators     
    hsa-miR-769-5p 0.34 26.2 .0066 E 
    hsa-miR-592 0.44 35.9 .0472 E 
    hsa-miR-126 0.46 37.6 .0022 E 
    hsa-miR-365 1.20 129.3 .0474 E 

E indicates expressed.

*

The fold change represents the calculated ratio (Fbg/Tot Prot) in log2 compared with the reference condition transfected with a negative control miRNA precursor molecule.

†

This relative change represents the percentage of decrease or increase in fibrinogen production compared with the reference condition transfected with a negative control miRNA precursor molecule.

‡

Two-sided t test, tested miRNA (n = 3) versus negative control miRNA (n = 3).

§

This miRNA is expressed in liver but not in HuH7 cells.

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