Kinetics of PML-RARα transcript levels
| UPN . | At entry . | After induction . | After consolidation #1 . | After consolidation #2 . | After consolidation #3 . |
|---|---|---|---|---|---|
| 1 | 3000 | N | N | Off study | Off study |
| 2 | 460 | N | N | N | N |
| 3 | 60 000 | <50 | N | N | N |
| 4 | 4200 | <50 | N | N | NA |
| 5 | 69 000 | 28 000 | 760 | 140 | <50 |
| 6 | 32 000 | 6000 | N | N | N |
| 7 | 15 000 | 290 | N | N | N |
| 8 | 360 000 | <50 | N | N | N |
| 9 | NA | 1000 | N | NA | N |
| 10 | NA | Off study | Off study | Off study | Off study |
| 11 | 950 | N | NA | N | N |
| 12 | 64 000 | 50 | N | NA | N |
| 13 | 10 000 | 7100 | Off study | Off study | Off study |
| 14 | 120 000 | 400 | NA | Off study | Off study |
| 15 | 510 000 | 150 | N | N | NA |
| 16 | 190 000 | <50 | N | N | NA |
| 17 | 95 000 | 1800 | 110 | 110 | N |
| 18 | 67 000 | 1500 | 480 | 390 | 280 |
| 19 | 130 000 | Off study | Off study | Off study | Off study |
| 20 | 450 000 | 280 000 | N | N | N |
| 21 | 140 000 | 170 | N | N | N |
| 22 | 26 000 | 61 | N | N | N |
| 23 | 24 000 | Off study | Off study | Off study | Off study |
| 24 | 730 000 | <50 | N | N | N |
| 25 | 1900 | 2500 | <50 | N | N |
| 26 | 440 000 | Off study | Off study | Off study | Off study |
| 27 | NA | 7800 | N | N | N |
| 28 | NA | 2600 | N | N | N |
| 29 | 510 | 6300 | Off study | Off study | Off study |
| 30 | 45 000 | 65 | N | N | Off study |
| 31 | NA | 300 000 | NA | N | N |
| 32 | NA | 50 | N | N | N |
| 33 | 180 000 | NA | Off study | Off study | Off study |
| 34 | 20 000 | N | N | N | N |
| 35 | 150 000 | 10 000 | N | N | N |
| UPN . | At entry . | After induction . | After consolidation #1 . | After consolidation #2 . | After consolidation #3 . |
|---|---|---|---|---|---|
| 1 | 3000 | N | N | Off study | Off study |
| 2 | 460 | N | N | N | N |
| 3 | 60 000 | <50 | N | N | N |
| 4 | 4200 | <50 | N | N | NA |
| 5 | 69 000 | 28 000 | 760 | 140 | <50 |
| 6 | 32 000 | 6000 | N | N | N |
| 7 | 15 000 | 290 | N | N | N |
| 8 | 360 000 | <50 | N | N | N |
| 9 | NA | 1000 | N | NA | N |
| 10 | NA | Off study | Off study | Off study | Off study |
| 11 | 950 | N | NA | N | N |
| 12 | 64 000 | 50 | N | NA | N |
| 13 | 10 000 | 7100 | Off study | Off study | Off study |
| 14 | 120 000 | 400 | NA | Off study | Off study |
| 15 | 510 000 | 150 | N | N | NA |
| 16 | 190 000 | <50 | N | N | NA |
| 17 | 95 000 | 1800 | 110 | 110 | N |
| 18 | 67 000 | 1500 | 480 | 390 | 280 |
| 19 | 130 000 | Off study | Off study | Off study | Off study |
| 20 | 450 000 | 280 000 | N | N | N |
| 21 | 140 000 | 170 | N | N | N |
| 22 | 26 000 | 61 | N | N | N |
| 23 | 24 000 | Off study | Off study | Off study | Off study |
| 24 | 730 000 | <50 | N | N | N |
| 25 | 1900 | 2500 | <50 | N | N |
| 26 | 440 000 | Off study | Off study | Off study | Off study |
| 27 | NA | 7800 | N | N | N |
| 28 | NA | 2600 | N | N | N |
| 29 | 510 | 6300 | Off study | Off study | Off study |
| 30 | 45 000 | 65 | N | N | Off study |
| 31 | NA | 300 000 | NA | N | N |
| 32 | NA | 50 | N | N | N |
| 33 | 180 000 | NA | Off study | Off study | Off study |
| 34 | 20 000 | N | N | N | N |
| 35 | 150 000 | 10 000 | N | N | N |
“Off study” indicates that the patient discontinued the study for reasons detailed in the text.
The threshold for quantification was 50 copies per µg RNA, which corresponds to a sensitivity of 10−4. The levels below the threshold were differentiated into “not detected (N)” and “detected but not quantifiable (<50).”
N, not detected; NA, not assessed.