Drugs with evidence for association with thrombocytopenia by clinical data in published case reports and identification of drug-dependent, platelet-reactive antibodies, and/or data mining of the AERS database
Drug . | Methods of association with thrombocytopenia . | |
---|---|---|
Case reports, laboratory testing, and data mining . | Case reports and laboratory testing only . | |
Abciximab*† | + | |
Acetaminophen‡ | + | |
Amiodarone | − | + |
Ampicillin | + | |
Carbamazepine*† | + | |
Eptifibatide† | + | |
Ethambutol | + | |
Haloperidol | + | |
Ibuprofen‡ | + | |
Irinotecan | + | |
Naproxen‡ | + | |
Oxaliplatin | + | |
Phenytoin† | + | |
Piperacillin† | + | |
Quinidine*† | + | |
Quinine*† | + | |
Ranitidine | + | |
Rifampin*† | + | |
Simvastatin | + | |
Sulfisoxazole | + | |
Tirofiban† | + | |
Trimethoprim-sulfamethoxazole*† | + | |
Valproic acid | + | |
Vancomycin† | + |
Drug . | Methods of association with thrombocytopenia . | |
---|---|---|
Case reports, laboratory testing, and data mining . | Case reports and laboratory testing only . | |
Abciximab*† | + | |
Acetaminophen‡ | + | |
Amiodarone | − | + |
Ampicillin | + | |
Carbamazepine*† | + | |
Eptifibatide† | + | |
Ethambutol | + | |
Haloperidol | + | |
Ibuprofen‡ | + | |
Irinotecan | + | |
Naproxen‡ | + | |
Oxaliplatin | + | |
Phenytoin† | + | |
Piperacillin† | + | |
Quinidine*† | + | |
Quinine*† | + | |
Ranitidine | + | |
Rifampin*† | + | |
Simvastatin | + | |
Sulfisoxazole | + | |
Tirofiban† | + | |
Trimethoprim-sulfamethoxazole*† | + | |
Valproic acid | + | |
Vancomycin† | + |
Twenty-four drugs with evidence for a causal association with thrombocytopenia by both clinical data from published case reports and by identification of drug-dependent, platelet-reactive antibodies are listed. Twenty-three of these drugs also had a statistically significant reporting association with thrombocytopenia by data mining of the AERS database.
These 6 drugs had clinical evidence for a causal association with thrombocytopenia in 10 or more case reports.
These 11 drugs had evidence for a causal association with thrombocytopenia by detection of drug-dependent, platelet reactive antibodies in 10 or more patients.
For acetaminophen and naproxen, drug-dependent antibodies have been identified only for metabolites and do not react with the unmodified drug. For ibuprofen, drug-dependent antibodies that reacted with the unmodified drug have been identified in some patients; in other patients, drug-dependent antibodies only reacted with metabolites of ibuprofen.