Table 2

Drugs with evidence for association with thrombocytopenia by clinical data in published case reports and identification of drug-dependent, platelet-reactive antibodies, and/or data mining of the AERS database

DrugMethods of association with thrombocytopenia
Case reports, laboratory testing, and data miningCase reports and laboratory testing only
Abciximab*  
Acetaminophen  
Amiodarone − 
Ampicillin  
Carbamazepine*  
Eptifibatide  
Ethambutol  
Haloperidol  
Ibuprofen  
Irinotecan  
Naproxen  
Oxaliplatin  
Phenytoin  
Piperacillin  
Quinidine*  
Quinine*  
Ranitidine  
Rifampin*  
Simvastatin  
Sulfisoxazole  
Tirofiban  
Trimethoprim-sulfamethoxazole*  
Valproic acid  
Vancomycin  
DrugMethods of association with thrombocytopenia
Case reports, laboratory testing, and data miningCase reports and laboratory testing only
Abciximab*  
Acetaminophen  
Amiodarone − 
Ampicillin  
Carbamazepine*  
Eptifibatide  
Ethambutol  
Haloperidol  
Ibuprofen  
Irinotecan  
Naproxen  
Oxaliplatin  
Phenytoin  
Piperacillin  
Quinidine*  
Quinine*  
Ranitidine  
Rifampin*  
Simvastatin  
Sulfisoxazole  
Tirofiban  
Trimethoprim-sulfamethoxazole*  
Valproic acid  
Vancomycin  

Twenty-four drugs with evidence for a causal association with thrombocytopenia by both clinical data from published case reports and by identification of drug-dependent, platelet-reactive antibodies are listed. Twenty-three of these drugs also had a statistically significant reporting association with thrombocytopenia by data mining of the AERS database.

*

These 6 drugs had clinical evidence for a causal association with thrombocytopenia in 10 or more case reports.

These 11 drugs had evidence for a causal association with thrombocytopenia by detection of drug-dependent, platelet reactive antibodies in 10 or more patients.

For acetaminophen and naproxen, drug-dependent antibodies have been identified only for metabolites and do not react with the unmodified drug. For ibuprofen, drug-dependent antibodies that reacted with the unmodified drug have been identified in some patients; in other patients, drug-dependent antibodies only reacted with metabolites of ibuprofen.

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