Characteristics of exon 28 SNPs in African American and Caucasian controls
| . | SNP status . | No. (%) . | Mean VWF:Ag, IU/dL . | Mean VWF:RCo, IU/dL . | Mean ratio of VWF:RCo/VWF:Ag . |
|---|---|---|---|---|---|
| African American | D1472H alone | 23 (39) | 122 | 93 | 0.77 |
| D1472H | 13 (22) | 135 | 93 | 0.71 | |
| I1380V | |||||
| N1435S | |||||
| No SNPs | 22 (37) | 124 | 112 | 0.91 | |
| Caucasian | D1472H alone | 19 (17) | 121 | 98 | 0.82 |
| D1472H | 3 (3) | 126 | 97 | 0.77 | |
| I1380V | |||||
| N1435S | |||||
| No SNPs | 91 (81) | 97 | 94 | 0.97 |
| . | SNP status . | No. (%) . | Mean VWF:Ag, IU/dL . | Mean VWF:RCo, IU/dL . | Mean ratio of VWF:RCo/VWF:Ag . |
|---|---|---|---|---|---|
| African American | D1472H alone | 23 (39) | 122 | 93 | 0.77 |
| D1472H | 13 (22) | 135 | 93 | 0.71 | |
| I1380V | |||||
| N1435S | |||||
| No SNPs | 22 (37) | 124 | 112 | 0.91 | |
| Caucasian | D1472H alone | 19 (17) | 121 | 98 | 0.82 |
| D1472H | 3 (3) | 126 | 97 | 0.77 | |
| I1380V | |||||
| N1435S | |||||
| No SNPs | 91 (81) | 97 | 94 | 0.97 |
I1380V and N1435S were only found in heterozygous form. All the Caucasian controls with D1472H were heterozygous for this SNP, whereas 35% of the African American controls with D1472H were homozygous for the H allele. One African American subject had I1380V and D1472H (not included in table).
SNP indicates single nucleotide polymorphism; VWF, von Willebrand Factor; Ag, antigen; IU, International Unit; and RCo, ristocetin cofactor.