Outcome of 297 MLL+ ALL patients according to the risk group stratification
| . | Medium risk . | High risk . | ||
|---|---|---|---|---|
| Chemo . | HSCT . | Chemo . | HSCT . | |
| No. of patients | 200 (67%) | 97 (33%) | ||
| Deaths in induction | 5 | 6 | ||
| Resistance/deaths | 5/3 | 4/4 | ||
| CR1, total | 190 (95%) | 87 (90%) | ||
| CR1 | 169 | 21 | 71 | 16 |
| Relapses | 78 (46%) | 8 (38%) | 55 (77%) | 6 (38%) |
| < 5 months from CR1/deaths | 19/15 | 2/2 | 24/23 | 0/0 |
| ≥ 5 months from CR1/deaths | 59*/46 | 6/4 | 31*/28 | 6/4 |
| Deaths in CCR | 10 (6%) | 1 (5%) | 6 (8%) | 1 (6%) |
| < 5 months from CR1 | 6 | 0 | 5 | 0 |
| ≥ 5 months from CR1 | 4† | 1 | 1† | 1 |
| Second malignancy | 0 | 0 | 0 | 0 |
| CCR | 81 (48%) | 12 (57%) | 10 (14%) | 9 (56%) |
| 4-year EFS (SE) | 45.6 (3.6) | 18.6 (5.1) | ||
| . | Medium risk . | High risk . | ||
|---|---|---|---|---|
| Chemo . | HSCT . | Chemo . | HSCT . | |
| No. of patients | 200 (67%) | 97 (33%) | ||
| Deaths in induction | 5 | 6 | ||
| Resistance/deaths | 5/3 | 4/4 | ||
| CR1, total | 190 (95%) | 87 (90%) | ||
| CR1 | 169 | 21 | 71 | 16 |
| Relapses | 78 (46%) | 8 (38%) | 55 (77%) | 6 (38%) |
| < 5 months from CR1/deaths | 19/15 | 2/2 | 24/23 | 0/0 |
| ≥ 5 months from CR1/deaths | 59*/46 | 6/4 | 31*/28 | 6/4 |
| Deaths in CCR | 10 (6%) | 1 (5%) | 6 (8%) | 1 (6%) |
| < 5 months from CR1 | 6 | 0 | 5 | 0 |
| ≥ 5 months from CR1 | 4† | 1 | 1† | 1 |
| Second malignancy | 0 | 0 | 0 | 0 |
| CCR | 81 (48%) | 12 (57%) | 10 (14%) | 9 (56%) |
| 4-year EFS (SE) | 45.6 (3.6) | 18.6 (5.1) | ||
ALL indicates acute lymphoblastic leukemia; HSCT, hematopoietic stem cell transplantation; CR1, first complete remission; Chemo, chemotherapy only; CCR, continuous complete remission; and EFS, event-free survival.
Nineteen of 59 relapses in the medium risk group and 13 of 31 relapses in the high risk group occurred within 9 months from CR1 (maximum waiting time to HSCT).
Two of 4 deaths in the medium risk group and none in the high risk group occurred within 9 months from CR1 (maximum waiting time to HSCT).